Results 81 to 90 of about 47,594 (303)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Overcoming Pulse Mixing and Signal Tailing in Laser Ablation Inductively couplet Plasma Mass Spectrometry Depth Profiling

, 2005
The laser ablation-induced plasma was used as a composition-controlled source for ion implantation in Si crystals. Then, laser ablation in combination with inductively coupled plasma mass spectrometry was used for the elemental depth profiling of the ...
BELLONI, fabio, DORIA, Domenico, OVERCOMING PULSE MIXING AND SIGNAL TAILING IN LASER ABLATION INDUCTIVELY COUPLET PLASMA MASS SPECTROMETRY DEPTH PROFILING, LORUSSO, ANTONELLA, D. BLEINER, NASSISI, Vincenzo, J. A.N.A.L. A.T. SPECTOM   +6 more
core  

Tailing Dam Failure in India

, 2019
The data set contain a list of tailing dams failure in ...
Bishwal, R (via Mendeley Data)
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

KERANGKA REGULASI KEGIATAN PASCATAMBANG BENDUNGAN TAILING DI INDONESIA

, 2021
Selama 50 tahun terakhir, 63 kegagalan struktur bendungan tailing terjadi di seluruh dunia dan menunjukkan tren jumlah dan keparahan yang terus meningkat sejak tahun 1990.  Di Indonesia, kegiatan pertambangan mineral logam menghasilkan ratusan juta ton ...
Anbiyak, Nur, Octavya, Putri Elma, Sudrajat, Jajat   +2 more
core   +1 more source

The use of the organic-inorganic hybrid polymer Al(OH)(3)-polyacrylamide to flocculate particles in the cyanide tailing suspensions

, 2016
The organic-inorganic hybrid polymer Al(OH)(3)-polyacrylamide (Al-PAM) was investigated in flocculation of particles in 10 wt% cyanide tailing suspensions in this study.
Yu, Yang, Lv, Cuicui, Zhang, Xiaomeng, Chen, Yunfa, Ye, Shufeng, Ding, Jian, Qian, Peng, Liu, Ya   +7 more
core   +1 more source

Guest editorial: Special issue introduction: e-tailing: the current landscape and future developments

, 2021
In this special issue “E-tailing: the current landscape and future developments”, the Asia Pacific Journal of Marketing and Logistics presents a series of papers covering topics to gain a better understanding of online shopping behaviour, marketing ...
Brown, James R., Thaichon, Park, Weaven, Scott, Brown, James R   +3 more
core   +1 more source