Results 121 to 130 of about 176,284 (364)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Research Progress on Comprehensive Utilization of Molybdenum Tailings

open access: yesKuangchan zonghe liyong
A large number of tailings are produced in the process of molybdenum ore separation, and the tailings accumulate and occupy a lot of land, which has hidden dangers and has an adverse impact on the ecological environment.
Riheng ZHANG, Qingjun KOU, Geng AN
doaj   +1 more source

The Effects of Surface Disturbances on the Leaching of Heavy Metals [PDF]

open access: yes, 1987
The harmful effects of heavy metal contamination of surface waters impacted by gold mining activity are well documented. An examination was conducted on the effects of surface disturbances in Wade Creek on the concentrations of heavy metals in ...
Brown, Edward J., Dixson, David P.
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Spatial Evolution Analysis of Tailings Flow from Tailings Dam Failure Based on MacCormack-TVD

open access: yesApplied Sciences
Adopting an appropriate method to analyze the spatial evolution process of tailings flow after tailings dam failure can provide a rational assessment of the inundation range and evaluate the subsequent disaster.
Lei Ma   +3 more
doaj   +1 more source

Reading Wordsworth in the Tar Sands [PDF]

open access: yes, 2015
A report, in the form of a long poem, on the author\u27s participation in the 5th annual Tar Sands Healing Walk, organized by the Athabasca Chipewyan First Nation, in Fort McMurray ...
Collis, Stephen S
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Home - About - Disclaimer - Privacy