Results 81 to 90 of about 40,715 (248)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Early hydration and mechanical performance of composited cementitious system prepared from high temperature calcined molybdenum tailings

Case Studies in Construction Materials
To improve the recycling of solid waste and achieve the secondary utilization of waste resources, this study investigates the preparation of molybdenum tailings composited binders by high temperature calcination using molybdenum tailings, limestone ...
Jun Li, Zhenwei Yang, Qian Su, Chang Cai, Hesong Jin, Qingxin Xue, Ruizhu Tian, Jiao Liu, Lingkun Chen, Tianchun Wang, Tuan Ngo   +10 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Tubifex : A biological method for dewatering oil sands tailings

, 2015
In Northern Alberta’s oil sands region, there are more than 800 million m³ tailings occupying more than 180 km² of tailings ponds. The suspended solids (mostly silts and clays), gradually densify to 25 to 40 wt% solids in 2-5 years.
de Lucas Pardo, Miguel, Chen, Qun, Sittoni, Luca, Yang, Xiaojuan, Ulrich, Ania, Deng, Lijun   +5 more
core   +1 more source

Disposal of solid waste as building materials: A study on the mechanical and durability performance of concrete composed of gold tailings

Journal of Materials Research and Technology
The purpose of this study is to explore the possibility of gold tailings as an alternative to natural river sand for preparing concrete, to solve the problems of rapid increase in gold tailings and insufficient natural river sand stock.
Qiang Song, Yingjie Zou, Jiuwen Bao, Peng Zhang   +3 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Tailings mobilization estimates for dam breach studies

, 2015
Quantitative assessment of potential consequences caused by a flood from a dam breach of a tailings facility requires an estimate of the volume of water and tailings released during the breach.
Fontaine, Daniel, Martin, Violeta
core   +1 more source

Numerical Analysis for the Stress-Strain Evaluation of the Conversion of a Conventional Slurry Tailings Storage Facility to Filtered Tailings Storage Facility, Considering Different Scenarios

, 2023
This article presents numerical simulations to evaluate the stress-strain behaviour for the conversion of a conventional slurry tailings storage facility (TSF) to a filtered tailings storage facility (FTSF), considering various filtered tailings stacking
Ramírez-Chávez, Rigoberto, Ang, Eduardo, Vargas-Moreno, Carlos Omar, Guillén-Guillén, Jorge Bricio, Servigna, Daniel, Preciado, Humberto F.   +5 more
core   +1 more source