Results 71 to 80 of about 29,738 (318)
Transition to Filtered Tailings at LaRonde Gold Mine
, 2023 Since 1988, LaRonde Gold Mine (LaRonde) has exploited a polymetallic orebody in Quebec, Canada. Slurry tailings are deposited in two tailings storage facilities (TSF) named “Main TSF” and “Extension A4.” At the end of 2022, Main TSF and Extension A4 TSF ...
Huza, Jessica +8 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
An integrated approach to AMD mitigation through sulfide removal from tailings
, 2010 Includes bibliographical references (leaves 67-73).The formation of acid mine drainage (AMD) from the microbial oxidation of sulfides in mineral waste deposits is one of the major challenges facing the mining industry worldwide.
Hesketh, Alexander H
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Tailings stewardship : “genuine” corporate responsibility
, 2015 Tailings Stewardship has come to the forefront of the mining industry’s attention following the Mt. Polley tailings dam breach in British Columbia, Canada. Recognizing the negative impacts a tailings dam failure has on a mining company’s corporate social
Fuller, Matt, Jacobs, Mike
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Compaction criteria for metal and nonmetal tailings [PDF]
"The Bureau of Mines studied the compaction characteristics of metal and nonmetal tailings. Densities of the tailings and zone of compaction influence, compactive effort, and cost of equipment are related to changes in the factor of safety for specific ...
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, 2023 This article presents numerical simulations to evaluate the stress-strain behaviour for the conversion of a conventional slurry tailings storage facility (TSF) to a filtered tailings storage facility (FTSF), considering various filtered tailings stacking
Ramírez-Chávez, Rigoberto +5 more
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