Results 121 to 130 of about 1,995 (245)

Impact of TAK-003 on epidemiologic, economic and quality-of-life burden of dengue: comparison of the results from a dynamic transmission model and a static model with a dynamic component

open access: yesInternational Journal of Infectious Diseases
Introduction: Dynamic transmission models are commonly used to evaluate the impact of vaccination as they capture both direct and indirect effects; however, they tend to be complex and computationally intensive.
Elizaveta Kharitonova   +6 more
doaj   +1 more source

Electric‐Current‐Induced Phase Transformation in Cu6Sn5 Below Its Equilibrium Transition Temperature

open access: yesAdvanced Science, EarlyView.
Electric current induces a monoclinic‐to‐hexagonal phase transformation in Cu6Sn5 at a measured bulk temperature of ∼120°C, below the equilibrium transition temperature. Ex situ synchrotron x‐ray diffraction, TEM, and matched thermal controls show that current stressing promotes the formation of a retained hexagonal η‐phase post‐stress state not ...
Shih‐kang Lin   +3 more
wiley   +1 more source

Rewiring NADH Metabolism Through NQO1‐Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy

open access: yesAdvanced Science, EarlyView.
ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang   +10 more
wiley   +1 more source

Opportunities and challenges of mRNA technologies in development of dengue virus vaccine

open access: yesFrontiers in Immunology
Dengue virus (DENV) is a mosquito-borne virus with a significant human health concern. With 390 million infections annually and 96 million showing clinical symptoms, severe dengue can lead to life-threatening conditions like dengue hemorrhagic fever (DHF)
Xiaoyang Liu
doaj   +1 more source

Efectividad y seguridad de la vacuna tetravalente TAK-003 contra el dengue: una revisión sistemática [PDF]

open access: yes
In Argentina, the dengue virus has experienced an increase in recent years. This study aims to conduct a systematic review to evaluate the effectiveness and safety of the TAK-003 tetravalent dengue vaccine in this context.
Bengolea, AgustIn   +5 more
core   +1 more source

Mechanically Adaptive Polyimide Interfaces for Stable High‐Voltage NCM–Sulfide All‐Solid‐State Batteries

open access: yesAdvanced Science, EarlyView.
A mechanically adaptive polyimide interface dynamically stabilizes single‐crystal cathodes in sulfide all‐solid‐state batteries. By integrating robust chemical coordination with viscoelastic compliance, this smart coating suppresses parasitic reactions and accommodates cyclic volume expansion.
Jiatao Wu   +8 more
wiley   +1 more source

Refining uncertainty about the TAK-003 dengue vaccine with a multi-level model of clinical efficacy trial data

open access: yes
Abstract Background A safe and effective vaccine that can be universally administered would represent a major advance in efforts to control dengue. Takeda’s TAK-003 is a potential candidate for such a vaccine. However, phase-III trial results suggest that TAK-003 confers differential protection by outcome, serotype, and serostatus.
Manar Alkuzweny   +2 more
openaire   +2 more sources

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

open access: yesAdvanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong   +12 more
wiley   +1 more source

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