Results 61 to 70 of about 290,795 (285)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Smart Sports Recruitment: Leveraging Software for Talent Precision

Journal of Coaching and Sports Science
This research highlights the critical role of technology in sports, particularly in identifying and developing talent more effectively. Technology enables better athlete performance analysis; however, talent identification still relies on traditional ...
Muhammad Ramli Buhari, Jance Jacob Sapulete, Muhammad Imran Hasanuddin, Susilawati Susilawati   +3 more
doaj   +1 more source

The Identification of Sport Talents Using a Sport Search

Juara, 2021
This study aims to identify students who have talent based on the results of the talent analysis conducted at SMP 1 Rambah Rokan Hulu. This research method is a quantitative descriptive method.
Ridwan Sinurat, Tofikin Tofikin
doaj   +1 more source

Talent identification transparency: an alternative perspective

European J. of International Management, 2019
Over the course of the last decade, talent management has attracted a great deal of attention in the academic literature. Even though the field has evolved, much scepticism continues to surround it, and many questions are still to be answered that may bridge existing gaps between science and practice.
Vaiman, Vlad, Kostanek, Edyta, Khoreva, Violetta   +2 more
openaire   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Investigating coaches’ general beliefs on defining and identifying talent in basketball

Frontiers in Psychology
Coaches have various challenging tasks to handle, including athlete development and selection. Selection decisions are often based on the coach’s eye. That is, coaches use their experience and intuition to generate holistic and subjective evaluations of ...
Till Koopmann, Arne Chorengel, Jörg Schorer   +2 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Validation of a diagnostic tool for identification of preschoolers and primary pupils with science talent

Envigogika, 2019
The paper focuses on validation of a diagnostic tool for identification of naturalist intelligence and science talent at pre-school and early school level (Jančaříková, 2009).
Kateřina Jančaříková
doaj   +1 more source

Talent identification of wrestling athletes using the analytic hierarchy process method approach

Sriwijaya Journal of Sport, 2023
The research aims to identify the talent of wrestlers aged 10 to 14 years. The data collected was analysed using the Analytic Hierarchy Process (AHP) with the Expert Choice v. 11 application to find out which elements play an important role in supporting
Fendi Ferdiana, Agus Rusdiana, Iman Imanudin, Badruzaman Badruzaman, Angga M. Syahid, Tono Haryono, Iwa Ikhwan Hidayat Iwa Ikhwan Hidayat   +6 more
doaj   +1 more source