Results 51 to 60 of about 2,428,515 (232)

Sporcuların başarısında genetik faktörlerin önemi

Spormetre Beden Eğitimi ve Spor Bilimleri Dergisi, 2017
Genetik faktörlerin atletik performansta önemli olduğu bilinen dayanıklılık, güç, kuvvet, kas fibril kompozisyonu gibi birçok bileşenle doğrudan ilişkisi bulunmaktadır.
Recep Sürhat Müniroğlu, Gülhan Erdem Subak, Özdemir Fatma Neşe Şahin   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Unblocking the Lifeline of Talent. CEPS Policy Brief No. 306, 6 December 2013 [PDF]

, 2013
Against the background of looming demographic decline, the departure of the baby-boom generation from European labour markets and growing economic competitiveness from emerging economies, this CEPS Policy Brief, published jointly with the Bertelsmann ...
Busse, Mathias, Morehouse, Christal.
core  

Relative age effects in German youth A and B men's soccer teams: survival of the fittest?

Frontiers in Sports and Active Living
The study investigates relative age effects (RAE) in German youth soccer (Youth Bundesliga A: January 2004 to December 2005 and B: January 2006 to December 2007; highest league in German youth soccer) and its persistence in third-division players.
Florian Heilmann, Alexander Kuhlig, Oliver Stoll   +2 more
doaj   +1 more source

Talent Identification in Youth Football: A Systematic Review

Journal of Anthropology of Sport and Physical Education, 2020
Identification of talents in football is one of the most important tasks of coaches in youth football selection. The main focus of this paper was to review the available literature on talent identification in youth football. A systematic review of PubMEd,
Emir Mustafovic, Denis Causevic, Nedim Covic, Mirza Ibrahimovic, Haris Alic , Ensar Abazovic, Semir Masic   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Influence of Biological Maturation on the Career Trajectory of Football Players: Does It Predict Elite Success?

Journal of Functional Morphology and Kinesiology
Background: Early-maturing players tend to have physical advantages during formative stages, but it remains unclear whether these advantages translate into long-term professional success.
Saül Aixa-Requena, Albert Gil-Galve, Alejandro Legaz-Arrese, Vicenç Hernández-González, Joaquín Reverter-Masia   +4 more
doaj   +1 more source

Identifying the Components of the Talent Management of faculty Members in Universities of Medical Sciences: A Meta-synthetic Study [PDF]

مجله ایرانی آموزش در علوم پزشکی, 2021
Introduction: Talent management, especially in higher education, is important due to the main role it can play in tackling the global challenges and development of different countries. This study endeavored to identify the components of talent management
ٍElham keykha, Ahmad keykha
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Changes Over a Decade in Anthropometry and Fitness of Elite Austrian Youth Soccer Players

Frontiers in Physiology, 2019
Increases in physical (e.g., high-intensity running and sprinting), technical (e.g., passing rate), and tactical (e.g., player density) aspects made elite level soccer more challenging within the past years.
Christoph Gonaus, Jürgen Birklbauer, Stefan J. Lindinger, Stefan J. Lindinger, Thomas L. Stöggl, Erich Müller   +5 more
doaj   +1 more source