Results 81 to 90 of about 3,155,872 (310)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

The relative age in handball players in Portugal

open access: yesE-balonmano.com: Revista de Ciencias del Deporte, 2020
Relative age effect is a subject that has been studied as a differentiating factor between athletes’ development. This study aimed to determine whether handball players have more possibilities to get to high performance, according to the month and year ...
Paulo Sá   +4 more
doaj  

Comment on “Football-specific fitness testing: adding value or confirming the evidence?” [PDF]

open access: yes, 2014
The recent point–counter-point exchange arising from the article by Mendez-Villanueva and Buchheit (2013) (Football-specific fitness testing: Adding value or confirming the evidence?
Carling, C.,, Collins, D.
core   +1 more source

The Impact of COVID-19 on Selected Human Resource Management Functions: Recruitment & Selection, Talent Management and Performance Management

open access: yesInternational Journal of Applied Research in Business and Management
The primary objective of this investigation was to assess the influence of the COVID-19 pandemic on the realm of human resource management. Due to the limited existing research in this area, the researcher conducted this study to contribute to the ...
Makgato Koketso Adelaine   +2 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

What are the Best Practices for Measuring Learning Agility, Cognitive Ability, and Personal Inventory and How are Companies Currently Using Them? [PDF]

open access: yes, 2017
[Excerpt] Research shows that the careful use of talent assessments can result in increased productivity, cost savings and better retention of top employees.
Sims, Lauren, Tao, Jiayu
core   +1 more source

Talent Management in European SMEs: case analysis between Slovenia and Poland [PDF]

open access: yes, 2019
Organisations are investing significant efforts and resources into recruiting, developing and retaining key talent with the potential to contribute significantly to performance. However, the talent management (TM) process is difficult and despite all the
Kohont, Andrej   +2 more
core   +2 more sources

Talent Production in Interaction

open access: yesCommunication & Sport, 2016
In sports, there is an extensive interest in identifying and selecting talented children in order to develop elite adult athletes. The process of selecting and screening talents involves not only physical and technical skills but also efforts to find adequate personality traits. Therefore, different types of performance appraisal interviews (PAIs) are
Kilger, Magnus, Jonsson, Rickard
openaire   +3 more sources

Selection and re-selection throughout a national talent pathway: Exploring longitudinal relative age effects in Northern Ireland male soccer

open access: yesHigh Ability Studies
The purpose of this study was to investigate the longitudinal prevalence of relative age effects (RAEs) across playing levels and positions in Northern Ireland international male soccer.
Alexander B. T. McAuley   +4 more
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Home - About - Disclaimer - Privacy