Results 121 to 130 of about 248,228 (315)
Advanced Science, EarlyView.Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta +10 more
wiley +1 more source
Advanced Science, EarlyView.Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao +7 more
wiley +1 more source
Advanced Science, EarlyView.A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong +13 more
wiley +1 more source
Advanced Science, EarlyView.Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao +11 more
wiley +1 more source
Filistin Meselesi ve Türkiye Uluslararası Kongresi Tam Metin Bildiri Kitabı [PDF]
, 2017 Kitap (Açık Erişim)2017 yılında yapılan Filistin Meselesi ve Türkiye Kongresinde, Filistin Meselesinin Dünü, Bugünü ve Yarını, Kudüs’ün statüsü, Bölgesel ve küresel güçlerin Filistin politikaları, Filistin’in Sosyo-Ekonomik inşasında Türkiye’nin rolü ...
Kaleci, Fatih +4 more
core +1 more source
Advanced Science, EarlyView.In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu +12 more
wiley +1 more source
Structural Colors from Modulated Topological Defects in Molecular Smectic Liquid Crystals
Advanced Science, EarlyView.Rather than using dyes and pigments, nature produces the colors of some butterflies and beetles through optical interference phenomena. This study describes an original biomimetic strategy exploiting the spontaneous formation of modulated linear defects in thin films of 8CB, a common molecular liquid crystal.
Camille N. Mahyaoui +7 more
wiley +1 more source
, 1920 First Line: Where would the Salvation Army be without you, tambourine?First Line of Chorus: When I say "Tam" you hit your tambourineTitle of Larger Work: The Greenwich Village Follies of 1920Key: G ...
core
Advanced Science, EarlyView.A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang +5 more
wiley +1 more source
[Correspondence Between Tam Daidone and Barbara Jordan - August 1974] [PDF]
, 1974 Correspondence between Tam Daidone and Barbara Jordan discussing food supplement regulations made by the Food and Drug Administration (FDA) and a bill that would counter those regulations.
Daidone, Tam L. +1 more
core