Results 141 to 150 of about 1,432,264 (297)

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

Lighting up Macrophage Reprogramming Assists Immunosuppressive Niche Modulation in Primary Tumors and Tumor‐Draining Lymph Nodes of Breast Cancer

Advanced Science, EarlyView.
This study develops an intelligent NIR‐II‐responsive nanoplatform to combat immunosuppression in breast cancer. It enables real‐time visualization of macrophage activity via “off‐on” fluorescence while simultaneously reprogramming macrophages through the CSF‐1R and CD47‐SIRPα pathways.
Yingbo Li, Di Chang, Jie Yang, Ying Bai, Min Chen, Daoshuang Li, Zuoyu Xu, Jiaxin Yuan, Xiaoxuan Xu, Zhiqi Zhang, Yize Li, Zixin Chen, Jinbing Xie, Zebin Xiao, Shenghong Ju   +14 more
wiley   +1 more source

Thymoquinone Enhances Tamoxifen Efficacy Against Triple-Negative Breast Cancer by Targeting EMT Signaling. [PDF]

Int J Breast Cancer
Haque M, Shyanti RK, Sharma S, Wu H, Mishra MK.   +4 more
europepmc   +1 more source

Selective Electrolysis of Water Under Artificial Seawater Conditions Using Transition Metal Borate Anodes

Advanced Energy Materials, EarlyView.
The borate‐based cobalt‐iron catalyst promotes selective oxidation of water rather than chlorine evolution reaction during electrolysis of seawater. When integrated into a zero‐gap electrolyzer prototype, this catalyst supports robust splitting of artificial seawater into oxygen and hydrogen on an extended timescale.
Ananta R. Fareza, Hank Garg, Luis Miguel Azofra, Darcy Simondson, Tam D. Nguyen, Mohamed R. Rizk, Khang N. Dinh, Rosalie K. Hocking, Douglas R. MacFarlane, Hoang‐Long Du, Alexandr N. Simonov   +10 more
wiley   +1 more source

Targeting <i>SPP1</i> ⁺TAMs associated with liver metastasis reverses immunosuppression and synergizes with immunotherapy in colorectal cancer. [PDF]

J Immunother Cancer
Lin Y, Chen Z, Zhao S, Zhao L, Yang C, Zhu M, Ye Y, Wang S, Shen Z.   +8 more
europepmc   +1 more source

Can outsourcing pest and disease control help reduce pesticide expenditure? Evidence from rice farmers

Agribusiness, EarlyView.
Abstract Outsourcing pest and disease control (PDC) has grown rapidly worldwide, especially in developing countries. Although numerous studies have investigated various advantages of outsourcing PDC, little is known about its impact on pesticide expenditure.
Pengcheng Wang, Wanglin Ma, Mengling Diao   +2 more
wiley   +1 more source

Probing Steady‐State Carrier Properties and Charge Transport in Covalent Organic Framework by Frequency‐Domain Terahertz Spectroscopy

Angewandte Chemie, EarlyView.
This work reports a combined frequency‐domain and time‐domain terahertz (THz) spectroscopic approach to elucidate intrinsic carrier properties and transport mechanisms in framework materials over the extended 0.5–20 THz region. Subtle structural and chemical variations are shown to strongly influence THz charge‐transport behavior across the far ...
Satyapriya Nath, Saiprakash Rout, Mahalaxmi Samal, Snehal Haldankar, Md Habib Ahsan, Anol Mondal, Sudeep Tiwari, Adithyan Puthukkudi, Avani KV, Ashis K. Nandy, Shriganesh S. Prabhu, Himansu S. Biswal, Xinliang Feng, Bishnu P. Biswal   +13 more
wiley   +2 more sources

Exploring Vietnamese Students' Intention to Adopt AI-Powered Study Tools: Integrating TPB and TAM

Educational Process: International Journal
Background/purpose. The study addresses the lack of clear policies and ethical concerns surrounding AI use in Vietnamese universities, where debates continue over balancing AI’s benefits with risks of academic misconduct.
Thanh Huong Nguyen , Do Anh Tu Ha
doaj   +1 more source