Results 151 to 160 of about 248,228 (315)

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

TAM-targeted nanomedicine in cancer: biological basis, therapeutic strategies, and translational perspectives. [PDF]

Theranostics
Zhou L, Yuan F, Wu Y, Li X, Xiang D.
europepmc   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Nano-Immunotherapy Targeting TAMs: Precisely Regulating TAMs to Reverse Immunosuppressive TME. [PDF]

Int J Nanomedicine
Zhang JM, Dong CL, Li B.
europepmc   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Exploring Vietnamese Students' Intention to Adopt AI-Powered Study Tools: Integrating TPB and TAM

Educational Process: International Journal
Background/purpose. The study addresses the lack of clear policies and ethical concerns surrounding AI use in Vietnamese universities, where debates continue over balancing AI’s benefits with risks of academic misconduct.
Thanh Huong Nguyen , Do Anh Tu Ha
doaj   +1 more source

Tumor-Associated Macrophages in Hepatocellular Carcinoma: From Ontogeny and Heterogeneity to Immune Evasion and Therapeutic Targeting. [PDF]

J Hepatocell Carcinoma
Su Y, Liang Y, Zhong D, Chen Y, Ma SS, Huang X.   +5 more
europepmc   +1 more source

Inorganic Nanomaterials can Promote or Inhibit Tumor Metastasis Depending on Tumor Microenvironment Composition

Advanced Science, EarlyView.
As engineered nanomaterials gain prominence in cancer imaging and therapy, understanding their impact on tumor progression becomes increasingly critical. We demonstrate that gold and silica‐coated gold nanomaterials can either suppress or enhance breast cancer metastasis through distinct tumor microenvironment interactions, while identifying ...
Kiana Buttiens, Xiaoqi Zheng, Xueqi Fan, Mukaddes Izci, Christy Maksoudian, Irati Perez Gilabert, Tianjiao Chu, Filipa Goncalves, Jonas Dehairs, Johan Swinnen, Bella B. Manshian, Stefaan J. Soenen   +11 more
wiley   +1 more source

Tumor-educated macrophages promote cytokine-driven lung colonization in triple-negative breast cancer. [PDF]

Oncoimmunology
Rosado-Sanz M, Martínez-Alarcón N, Meel MH, Rius-Perez S, Tolboom ZJ, Salvador-Coloma C, Burgos-Panadero R, Coronado E, Montoliu G, Casals E, Esteve-Codina A, Ripoll F, Santaballa A, Font de Mora J.   +13 more
europepmc   +1 more source

Tam geniş ve tam esas alt modüller

, 2020
This thesis consists of six chapters.The first chapter includes the purpose of the thesis.In the second chapter preparatory information that will be used later is given.In the third chapter essential submodule is defined and properties of essential submodule are investigated.The fourth chapter deals with strongly large submodule that makes strong the ...
openaire   +1 more source