Results 121 to 130 of about 113,809 (305)

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, EarlyView.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

Does Next Generation Sequencing (NGS)‐Based CYP2D6 Sequencing Improve Genotype–Phenotype Concordance in Tamoxifen‐Treated Patients?

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit, Julien Plenecassagnes, Aurelie Brice, Florence Dalenc, Ludovic Mallet, Etienne Chatelut, Ayman Al Saati, Fabienne Thomas   +7 more
wiley   +1 more source

Integrative Analysis of Response to Tamoxifen Treatment in ER-Positive Breast Cancer Using GWAS Information and Transcription Profiling

, 2012
Variable response and resistance to tamoxifen treatment in breast cancer patients remains a major clinical problem. To determine whether genes and biological pathways containing SNPs associated with risk for breast cancer are dysregulated in response to ...
Chindo Hicks, Lucio Miele, Antonio Pannuti, Ranjit Kumar   +3 more
core   +1 more source

Process and impact of mergers of NHS trusts: multicentre case study and management cost analysis. [PDF]

, 2002
OBJECTIVE: To study the processes involved in and impact of mergers between NHS trusts, including the effect on management costs. DESIGN: Cross sectional study involving in depth interviews and documentary analysis; case study to compare savings in ...
Normand, Charles, Walters, R, Protopsaltis, Gerasimos, Protopsaltis, G, Hutchings, A, Allen, P, Normand, C, King, A, Fulop, Naomi, Allen, Pauline, Hutchings, Andrew, Walters, Rhiannon, King, Annette   +12 more
core   +1 more source

Resolving CYP2D6 Structural Complexity with Long‐Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Cytochrome P450 2D6 (CYP2D6)‐mediated bioactivation of tamoxifen to endoxifen is a key determinant of therapeutic efficacy in estrogen receptor‐positive breast cancer. In Asian populations, the high prevalence of structurally complex CYP2D6 alleles complicates conventional genotyping, limiting accurate genotype–phenotype correlation.
Usa Boonyuen, Sirinyatorn Talukam, Beatriz Aira C. Jacob, Wayu Matphong, Kamonwan Chamchoy, Onrapak Reamtong, Nuntana Meesiripan, Junya Yamagishi, Matthew Phanchana, Chayanoot Rattadilok   +9 more
wiley   +1 more source

Effect of Tamoxifen and Raloxifene on the Proliferative Activity of the Breast Epithelium in Premenopausal Women

, 2015
Objectives To compare the effects of tamoxifen and raloxifene on the proliferative activity of normal breast tissue in premenopausal women as measured by Ki-67/MIB-1 expression.
Marise A. R. Moreira, Miliana T. Lucato, Ruffo Freitas-Junior, Regis R. Paulinelli, Sebastião A. Pinto, Leonardo R. Soares, Júlio R. M. Bernardes-Junior   +6 more
core   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Tamoxifen-treated naïve Cre⁺IFNαβR^f/f mount primary responses that are similar to those reported for conventional IFNαβR knockout animals.

, 2016
(A) LCMV naive UBC-Cre-ERT2+IFNαβRfl/fl and UBC-Cre-ERT2-IFNαβRfl/fl mice were injected with tamoxifen and ~9 weeks later were given a primary infection with LCMV.
J. Lindsay Whitton (44261), Claudia T. Flynn (51958), Martin P. Hosking (246686)   +2 more
core   +1 more source

CaMKIIβ insufficiency disrupts cortical networks, producing aberrant low‐gamma oscillations and seizure susceptibility

Epilepsia, EarlyView.
Abstract Objective Pathogenic variants in the calcium/calmodulin‐dependent protein kinase II B gene (CAMK2B) have been associated with neurodevelopmental disorders, including epilepsy, yet the mechanisms underlying cortical dysfunction remain largely unclear.
Hiroki Mutoh, Kazushi Aoto, Atsuo Fukuda, Hirotomo Saitsu   +3 more
wiley   +1 more source

¹¹C标记Tamoxifen的制备

四川大学学报. 自然科学版, 2000
报道了N 去甲基 Tamoxifen(N Demethyltamoxifen)和 11C标记Tamoxifen( 11C Tamox ifen)的制备及高效液相色谱 (HPLC)分离分析方法 .先将Tamoxifen柠檬酸盐 (TamoxifenCit rate)转换成无盐Tamoxifen(Tamoxifenfreebase) ,然后与 1 氯乙基 氯甲酸酯 (ACE Cl)反应生成N 去甲基 Tamoxifen .N 去甲基 Tamoxifen与 11CH3I在 1 3 0℃下反应 1 0min ...
刘宁, DING Yu-Shin
doaj