Results 131 to 140 of about 113,809 (305)

Clinicogenomic Features and Outcomes of Adenoid Cystic Carcinoma With Central Nervous System Metastases: A Single‐Institution Cohort Study

Head &Neck, EarlyView.
ABSTRACT Background Adenoid cystic carcinoma (ACC) is a rare malignancy with a propensity for perineural invasion and hematogenous spread. Central nervous system (CNS) involvement is uncommon, and detailed clinical and genomic data on this aspect of the disease remain limited.
Omar Elghawy, Jack Stylli, Martin Kurian, Eitan Halper‐Stromberg, Aditi Singh, Christopher D'Avella, Lee Hartner, Roger B. Cohen   +7 more
wiley   +1 more source

Effect of long term administration of tamoxifen on memory in male rat

مجله دانشگاه علوم پزشکی گرگان, 2016
Background and Objective: Tamoxifen is one of the selective estrogen receptor modulators that exerts estrogen / anti-estrogen effects in various tissues.
Asle-Rousta M
doaj  

The immunotoxin targeting PRLR increases tamoxifen sensitivity and enhances the efficacy of chemotherapy in breast cancer

Journal of Experimental & Clinical Cancer Research
Background Though tamoxifen achieves success in treating estrogen receptor α (ERα)-positive breast cancer, the followed development of tamoxifen resistance is a common challenge in clinic.
Jiawei Zhang, Junjun Liu, Yali Yue, Lei Wang, Qunye He, Shuyi Xu, Junyan Li, Yunji Liao, Yu Chen, Shusheng Wang, Yueqing Xie, Baohong Zhang, Yanlin Bian, Dimiter S. Dimitrov, Yunsheng Yuan, Jianwei Zhu   +15 more
doaj   +1 more source

Norcantharidin regulates ERα signaling and tamoxifen resistance via targeting miR-873/CDK3 in breast cancer cells.

PLoS ONE, 2019
MiR-873/CDK3 has been shown to play a critical role in ERα signaling and tamoxifen resistance. Thus, targeting this pathway may be a potential therapeutic approach for the treatment of ER positive breast cancer especially tamoxifen resistant subtype ...
Xiumei Zhang, Bingfeng Zhang, Panhong Zhang, Lihui Lian, Lianlian Li, Zhihong Qiu, Kai Qian, An Chen, Qiongqing Liu, Yinjie Jiang, Jiajun Cui, Bing Qi   +11 more
doaj   +1 more source

Identification of a Putative Protein Profile Associated with Tamoxifen Therapy Resistance in Breast Cancer

, 2009
Tamoxifen resistance is a major cause of death in patients with recurrent breast cancer. Current clinical factors can correctly predict therapy response in only half of the treated patients.
Kang, H, Timmermans, Mieke, Martens, John, Look, Maxime, den Bakker, Michael, Luider, Theo, Gelder, Marion, Foekens, John, Pasa-Tolic, L, Umar, Arzu, Jaitly, N   +10 more
core  

Drug-induced liver injury secondary to tamoxifen

Tamoxifen is a non-steroidal selective oestrogen receptor modulator commonly used in the treatment of breast cancer. It is associated with the development of fatty liver and steatohepatitis however drug-induced liver injury is rare.
Murphy, Grace, Subhaharan, Deloshaan, Azer, Mary, Commins, Natalie   +3 more
core   +1 more source

Clinical response after two cycles compared to HER2, Ki-67, p53, and bcl-2 in independently predicting a pathological complete response after preoperative chemotherapy in patients with operable carcinoma of the breast

, 2008
Introduction To investigate the predictive value of clinical and biological markers for a pathological complete remission after a preoperative dose-dense regimen of doxorubicin and docetaxel, with or without tamoxifen, in primary operable breast cancer ...
Sinn, Hans-Peter, Sibylle Loibl, Jens-Uwe Blohmer, Jörn Hilfrich, Eidtmann, Holger, Jackisch, Christian, Minckwitz, Gunter von, Elisabeth Merkle, Hilfrich, Jörn, Caputo, Angelika, Angelika Caputo, Merkle, Elisabeth, Dan Costa, Serban, Blohmer, Jens-Uwe, Gunter von Minckwitz, Raab, Günter, German Breast Group (GBG), [Study group], Christian Jackisch, Hans-Peter Sinn, Serban D Costa, Holger Eidtmann, Loibl, Sibylle, Manfred Kaufmann, von Minckwitz, Gunter, null null, Günter Raab, Costa, Serban D., Kaufmann, Manfred   +27 more
core   +1 more source

Preoperative and postoperative pathology concordance in endometrial intraepithelial neoplasia: A retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To assess the concordance between pre‐ and postoperative pathology in patients with endometrial intraepithelial neoplasia (EIN) undergoing hysterectomy, and identify predictors of malignancy, including sampling method, progestin therapy, and surgical timing.
Jenny Dimakos, Dong Bach Nguyen, Xing Zeng, Jessica Papillon Smith, Fady W. Mansour, Srinivasan Krishnamurthy, Andrew Zakhari   +6 more
wiley   +1 more source

Development of biodegradable polymer based tamoxifen citrate loaded nanoparticles and effect of some manufacturing process parameters on them: a physicochemical and in-vitro evaluation

, 2010
Basudev Sahana, Kousik Santra, Sumit Basu, Biswajit MukherjeeDepartment of Pharmaceutical Technology, Jadavpur University, Kolkata, IndiaAbstract: The aim of the present study was to develop nanoparticles of tamoxifen citrate, a non-steroidal ...
Sumit Basu, Basudev Sahana, et al, Biswajit Mukherjee, Kousik Santra   +4 more
core   +1 more source

Efficacy and related factors of levonorgestrel‐releasing intrauterine system combined with metformin in fertility‐preserving treatment for atypical endometrial hyperplasia and early endometrial cancer: A retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To compare the efficacy of the levonorgestrel‐releasing intrauterine system combined with metformin versus oral progestin combined with metformin in fertility‐preserving treatment for patients with atypical endometrial hyperplasia and early endometrial cancer, and to analyze related factors affecting efficacy.
Pengpeng Gu, Jialu Gao, Yuxin Li, Mei Huang, Xiaoshuang Wang, Xin Zhao   +5 more
wiley   +1 more source