Results 111 to 120 of about 122,604 (290)

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid‐Related Adverse Events Following Surgery for Breast Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Jyun‐Heng Lai, Anton L V Avanceña, Juan P Cata, Jamie C. Barner, Sharon H. Giordano, Chanhyun Park, Hui Zhao, Kirk E. Evoy, John K. Lin, Jennifer C. Spencer, Mariana Chavez‐MacGregor, Kelly K. Hunt, Kerollos Nashat Wanis   +12 more
wiley   +1 more source

Tamoxifen-inducible cardiac-specific disruption of Med1 (TmcsMed1^-/-) in adult mice causes dilated cardiomyopathy.

, 2016
(A) Relative Med1 mRNA expression in Med1fl/fl and TmcsMed1-/- mouse heart, liver and kidney. (B) Western blot analysis of Med1 in TmMed1fl/fl and TmcsMed1-/- hearts.
Varsha Shete (3070350), Ning Liu (168279), Philip M. Barger (3070359), Hossein Ardehali (238398), Matthew J. Schipma (2621923), Navin Viswakarma (498696), Tatsuya Sato (317466), Edward B. Thorp (3070353), Jing Liu (38537), Yi-Jun Zhu (3070356), Yuzhi Jia (498704), Bayar Thimmapaya (498705), Hsiang-Chun Chang (3070362), Yashpal S. Kanwar (25823), Janardan K. Reddy (203466)   +14 more
core   +1 more source

¹¹C标记Tamoxifen的制备

四川大学学报. 自然科学版, 2000
报道了N 去甲基 Tamoxifen(N Demethyltamoxifen)和 11C标记Tamoxifen( 11C Tamox ifen)的制备及高效液相色谱 (HPLC)分离分析方法 .先将Tamoxifen柠檬酸盐 (TamoxifenCit rate)转换成无盐Tamoxifen(Tamoxifenfreebase) ,然后与 1 氯乙基 氯甲酸酯 (ACE Cl)反应生成N 去甲基 Tamoxifen .N 去甲基 Tamoxifen与 11CH3I在 1 3 0℃下反应 1 0min ...
刘宁, DING Yu-Shin
doaj  

Dispensing of actionable pharmacogenetic drugs among adults receiving cardiovascular disease medications in the Northern Netherlands: A serial cross‐sectional study

Clinical Pharmacology &Therapeutics, EarlyView.
The extent of pharmacogenetic (PGx) drug dispensing among Dutch adults receiving medications for cardiovascular disease (CVD) is unknown. Using the University of Groningen IADB.nl pharmacy database, we performed a serial cross‐sectional study (2019–2023) to estimate the annual prevalence of PGx drug dispensing and annual rates of initiation.
Zhuolin Zhang, Guiling Zhou, Jens H. J. Bos, Eelko Hak, Talitha Feenstra, Frank Klont   +5 more
wiley   +1 more source

Effect of long term administration of tamoxifen on memory in male rat

مجله دانشگاه علوم پزشکی گرگان, 2016
Background and Objective: Tamoxifen is one of the selective estrogen receptor modulators that exerts estrogen / anti-estrogen effects in various tissues.
Asle-Rousta M
doaj  

The immunotoxin targeting PRLR increases tamoxifen sensitivity and enhances the efficacy of chemotherapy in breast cancer

Journal of Experimental & Clinical Cancer Research
Background Though tamoxifen achieves success in treating estrogen receptor α (ERα)-positive breast cancer, the followed development of tamoxifen resistance is a common challenge in clinic.
Jiawei Zhang, Junjun Liu, Yali Yue, Lei Wang, Qunye He, Shuyi Xu, Junyan Li, Yunji Liao, Yu Chen, Shusheng Wang, Yueqing Xie, Baohong Zhang, Yanlin Bian, Dimiter S. Dimitrov, Yunsheng Yuan, Jianwei Zhu   +15 more
doaj   +1 more source

Norcantharidin regulates ERα signaling and tamoxifen resistance via targeting miR-873/CDK3 in breast cancer cells.

PLoS ONE, 2019
MiR-873/CDK3 has been shown to play a critical role in ERα signaling and tamoxifen resistance. Thus, targeting this pathway may be a potential therapeutic approach for the treatment of ER positive breast cancer especially tamoxifen resistant subtype ...
Xiumei Zhang, Bingfeng Zhang, Panhong Zhang, Lihui Lian, Lianlian Li, Zhihong Qiu, Kai Qian, An Chen, Qiongqing Liu, Yinjie Jiang, Jiajun Cui, Bing Qi   +11 more
doaj   +1 more source

Neonatal Exposure to Antibiotics Triggers Obesity in Adulthood by Permanent Microbiota Dysbiosis and Reduction of Adipose Regulatory T Cells

Barrier Immunity, EarlyView.
ABSTRACT Neonatal dysbiosis of the gut microbiota represents a critical environmental factor promoting obesity, but the underlying immunological mechanisms remain unknown. We show here that neonatal treatment of mice with broad‐spectrum antibiotics for the first 3 weeks of life (NeoATB) resulted in the development of obesity and metabolic abnormalities
Peter Zanvit, Junji Xu, Wenjing Yang, Nancy Guo, Tianming Yu, Xue Jiao, Michaela Prochazkova, Wenwen Jin, Na Liu, Sang‐A Park, Cheryl Chia, Daxesh P. Patel, Dunfang Zhang, Nathan Goldberg, Alexander Cain, Frank J. Gonzalez, Yasmine Belkaid, Yingzi Cong, WanJun Chen   +18 more
wiley   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source