Results 91 to 100 of about 113,809 (305)

Tamoxifen for prevention of breast cancer: extended long-term follow-up of the IBIS-I breast cancer prevention trial

, 2014
© Cuzick et al. Open Access article distributed under the terms of CC BY.http://dx.doi.org/10.1016/S1470-2045(14)71171-
George, W, Lindsay, D, Eccles, D, Richmond, B, Henry, A, Mitine, C, Birrell, S, Dewar, J, Cuzick, J, Vergine, Beata, Howell, A; id_orcid, Beith, J, Fallowfield, L, Sestak, Ivana, Holli, K, Dowsett, M, Powles, T, Bird, A, Hamed, H, Cawthorn, S, Fentiman, I, Sauven, P, Cuzick, Jack, Campbell, I, Cawthorne, Simon, Holli, Kaija, Baum, M, Wilkinson, A, Wynne, C, Odling-Smee, W, Twentyman, P, Investigators, IBIS-I, Stotter, A, MacNeil, F, Collins, J P, Denton, L, Anderson, E, Abdi, E, MacMichael, K, Raytor, Z, Howell, Anthony, Buser, K, Newton, A, Blamey, R, Wilkinson, S, Godbolt, P, Ward, R, White, S, Evans, G; id_orcid, Lansdown, M, Stewart, R, Lee, M, Melmeth, A, Paksec, L, Thompson, A, Cawthorn, Simon, Forbes, J F, Chipman, M, Gebski, V, Craft, P, Atkinson, C, Earl, H, Seccombe, M, Sestak, I, Kealy, R, Forbes, JF, Boyages, J, Goldhirsch, A, Hanby, A, Hart, S, Hirst, C, Kirk, J, Mansel, R, Forbes, John F, Chapman, C, Sainsbury, R, Williamson, J, Underhill, C, Garcia, J, McAleese, P, Simes, R J, Maddox, P, Blum, R, Thornto, R, MacKay, J, Howell, A, Gilbert, F J, Hearne, J, Normand, C, Friedlander, M, Edwards, R, Pagani, O, Lennard, T, Toy, J, Robertson, J, Holcombe, C, Oivanen, T, Hamed, Hisham, Coates, A   +98 more
core   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source

Tamoxifen and hypercalcaemia

Annals of Oncology, 1993
The present case demonstrates the importance of close observation, also of serum calcium, when initiating tamoxifen therapy, especially in patients with known osseous metastases. Hypercalcaemia should also be considered as a possible cause of CNS symptoms in patients newly started on endocrine treatment.
openaire   +2 more sources

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Prior Adjuvant Tamoxifen Treatment in Breast Cancer Is Linked to Increased AIB1 and HER2 Expression in Metachronous Contralateral Breast Cancer.

PLoS ONE, 2016
AimThe estrogen receptor coactivator Amplified in Breast Cancer 1 (AIB1) has been associated with an improved response to adjuvant tamoxifen in breast cancer, but also with endocrine treatment resistance.
Sara Alkner, Pär-Ola Bendahl, Anna Ehinger, Kristina Lövgren, Lisa Rydén, Mårten Fernö   +5 more
doaj   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Tamoxifen evolution

British Journal of Cancer, 2023
A. Howell, S. J. Howell
openaire   +2 more sources

Molecular gene expression and genome wide profiling in tamoxifen-resistant breast cancer.

, 2010
PhDOestrogen receptor positive (ER+) breast cancers (BC) are heterogeneous in both their clinical behaviour and response to therapy. The ER and Progesterone (PgR) are currently the best predictors of response to the anti-oestrogen tamoxifen, yet up to 40%
Yeoh, Chit Cheng
core  

Tamoxifen-inducible cardiac-specific disruption of Med1 (TmcsMed1^-/-) in adult mice causes dilated cardiomyopathy.

, 2016
(A) Relative Med1 mRNA expression in Med1fl/fl and TmcsMed1-/- mouse heart, liver and kidney. (B) Western blot analysis of Med1 in TmMed1fl/fl and TmcsMed1-/- hearts.
Varsha Shete (3070350), Ning Liu (168279), Philip M. Barger (3070359), Hossein Ardehali (238398), Matthew J. Schipma (2621923), Navin Viswakarma (498696), Tatsuya Sato (317466), Edward B. Thorp (3070353), Jing Liu (38537), Yi-Jun Zhu (3070356), Yuzhi Jia (498704), Bayar Thimmapaya (498705), Hsiang-Chun Chang (3070362), Yashpal S. Kanwar (25823), Janardan K. Reddy (203466)   +14 more
core   +1 more source