Results 71 to 80 of about 122,604 (290)

A phase 3 study (PATHWAY) of palbociclib plus tamoxifen in patients with HR-positive/HER2-negative advanced breast cancer

npj Breast Cancer
Palbociclib combined with endocrine therapy is approved for treating patients with hormone-receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2−) advanced breast cancer; however, data on palbociclib combined with tamoxifen are ...
Emi Noguchi, Takashi Yamanaka, Hirofumi Mukai, Naohito Yamamoto, Chi-Feng Chung, Yen-Shen Lu, Dwan-Ying Chang, Joohyuk Sohn, Gun Min Kim, Kyung-Hun Lee, Soo-Chin Lee, Tsutomu Iwasa, Hiroji Iwata, Kenichi Watanabe, Kyung Hae Jung, Yuko Tanabe, Seok Yun Kang, Hiroyuki Yasojima, Kenjiro Aogi, Eriko Tokunaga, Sung Hoon Sim, Yoon Sim Yap, Koji Matsumoto, Ling-Ming Tseng, Yoshiko Umeyama, Kazuki Sudo, Yuki Kojima, Tomomi Hata, Aya Kuchiba, Taro Shibata, Kenichi Nakamura, Yasuhiro Fujiwara, Kenji Tamura, Kan Yonemori   +33 more
doaj   +1 more source

First-in-human pharmacokinetics of tamoxifen and its metabolites in the milk of a lactating mother: a case study

ESMO Open, 2020
BackgroundBreast cancer represents the most frequent neoplasm diagnosed in women of childbearing age. When the tumour is oestrogen receptor-positive, tamoxifen is among the recommended endocrine treatments.
Fedro Alessandro Peccatori, Giovanni Codacci-Pisanelli, Gunnar Mellgren, Barbara Buonomo, Eleonora Baldassarre, Ernst Asbjorn Lien, Ersilia Bifulco, Steinar Hustad, Emil Zachariassen, Harriet Johansson, Thomas Helland   +10 more
doaj   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Developmental malformations resulting from high-dose maternal tamoxifen exposure in the mouse.

PLoS ONE, 2021
Tamoxifen is an estrogen receptor (ER) ligand with widespread use in clinical and basic research settings. Beyond its application in treating ER-positive cancer, tamoxifen has been co-opted into a powerful approach for temporal-specific genetic ...
Miranda R Sun, Austin C Steward, Emma A Sweet, Alexander A Martin, Robert J Lipinski   +4 more
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Tamoxifen for the prevention of breast cancer results of Italian randomized tamoxifen prevention trial among women with hysterectomy

, 2007
Background Initial findings of the Italian Randomized Tamoxifen Prevention Trial found no reduction in risk of breast cancer with tamoxifen use, whereas the National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial showed that ...
Viale G, Costa A, G. Gucciardo, P. Maisonneuve, Oliviero P, Conforti S, D'Aiuto G, M. R. del Turco, M. A. Pizzichetta, Rotmensz N, A. Costa, P. Boyle, Italian Tamoxifen Study Group, Sacchini V, del Turco MR, S. Conforti, G. Viale, Bonanni B, M. G. Muraca, Travaglini R, R. Travaglino, G. D’Aiuto, U. Veronesi, N. Rotmensz, Decensi A, Lovison F, PAGNI, Paola, Gucciardo G, Muraca MG, Italian Tamoxifen Study Group:, Veronesi U, B. Bonanni, Boyle P, A. Decensi, V. Sacchini, P. Oliviero, Pizzichetta MA, F. Lovison, Maisonneuve P   +38 more
core   +1 more source

Tamoxifen-injected iMfn2^DA mice show impaired locomotion and DA neurodegeneration.

, 2021
Control and iMfn2DA mice were analyzed at 3, 6 and 9 weeks after tamoxifen or vehicle injection. (A) Spontaneous motor activity (horizontal activity, vertical activity and total distance) was measured in open field. ***p14. (B-C) Representative images of
Seungmin Lee (68256), Thomas Perlmann (11485872), Elena Sopova (11485866), Mara Mennuni (11485860), Viktor Jonsson (3467864), Katarína Tiklová (87618), Roberta Filograna (789459), Oleg Shupliakov (89781), Nils-Göran Larsson (106099), Camilla Koolmeister (11485869), Markus Ringnér (3876), Linda Gillberg (11485863), Lars Olson (157339)   +12 more
core   +1 more source

Comparative Effects of Tamoxifen and Anastrozole on Lipid Profile and Liver Enzymes in Patients with Breast Cancer [PDF]

Kirkuk Journal of Medical Sciences
Background: Breast cancer has emerged as one of the most common malignancies diagnosed among women worldwide. Hormone therapy with Tamoxifen or aromatase inhibitors is an essential part of the treatment for estrogen-receptor-positive breast cancer ...
Jangi Salai, Jwan Mohammed
doaj   +1 more source

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source