Results 81 to 90 of about 125,474 (196)

Phosphorylated c-Src in the nucleus is associated with improved patient outcome in ER-positive breast cancer [PDF]

, 2008
Elevated c-Src protein expression has been shown in breast cancer and <i>in vitro</i> evidence suggests a role in endocrine resistance. To investigate whether c-Src is involved in endocrine resistance, we examined the expression of both total
Cooke, T.G., Tatarov, O., Tovey, S, O Tatarov, V Brunton, T G Cooke, McDuff, E, E J Campbell, McDuff, E., Tovey, S., Edwards, J, E McDuff, Brunton, V.G., S Tovey, Brunton, V, J Edwards, Edwards, J., Campbell, E J, Tatarov, O, Campbell, E.J., Cooke, T G   +20 more
core   +1 more source

The antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifen-sensitive and tamoxifen-resistant human breast cancer cells

, 2009
Tamoxifen resistance is a major clinical problem in the treatment of estrogen receptor α-positive breast tumors. It is, at present, unclear what exactly causes tamoxifen resistance.
Yde, Christina W., Mouritsen, Ole G., Clausen, Mathias Porsmose; id_orcid, Yde, Christina Westmose, Lykkesfeldt, Anne E., Bennetzen, Martin, Guerra, Barbara; id_orcid, Clausen, Mathias P., Guerra, Barbara, Bennetzen, Martin V., Barbara Guerra, Anne E. Lykkesfeldt, Martin V. Bennetzen, Ole G. Mouritsen, Mathias P. Clausen, Christina W. Yde   +15 more
core   +1 more source

Effect of long term administration of tamoxifen on memory in male rat

مجله دانشگاه علوم پزشکی گرگان, 2016
Background and Objective: Tamoxifen is one of the selective estrogen receptor modulators that exerts estrogen / anti-estrogen effects in various tissues.
Asle-Rousta M
doaj  

The immunotoxin targeting PRLR increases tamoxifen sensitivity and enhances the efficacy of chemotherapy in breast cancer

Journal of Experimental & Clinical Cancer Research
Background Though tamoxifen achieves success in treating estrogen receptor α (ERα)-positive breast cancer, the followed development of tamoxifen resistance is a common challenge in clinic.
Jiawei Zhang, Junjun Liu, Yali Yue, Lei Wang, Qunye He, Shuyi Xu, Junyan Li, Yunji Liao, Yu Chen, Shusheng Wang, Yueqing Xie, Baohong Zhang, Yanlin Bian, Dimiter S. Dimitrov, Yunsheng Yuan, Jianwei Zhu   +15 more
doaj   +1 more source

Norcantharidin regulates ERα signaling and tamoxifen resistance via targeting miR-873/CDK3 in breast cancer cells.

PLoS ONE, 2019
MiR-873/CDK3 has been shown to play a critical role in ERα signaling and tamoxifen resistance. Thus, targeting this pathway may be a potential therapeutic approach for the treatment of ER positive breast cancer especially tamoxifen resistant subtype ...
Xiumei Zhang, Bingfeng Zhang, Panhong Zhang, Lihui Lian, Lianlian Li, Zhihong Qiu, Kai Qian, An Chen, Qiongqing Liu, Yinjie Jiang, Jiajun Cui, Bing Qi   +11 more
doaj   +1 more source

Identification of estrogenic tamoxifen metabolite(s) in tamoxifen-resistant human breast tumors.

, 1992
PURPOSE We have shown previously that acquired tamoxifen resistance in an in vivo experimental model is associated with reduced tamoxifen accumulation, isomerization of trans-4-hydroxytamoxifen, and tamoxifen-stimulated tumor growth.
V J Wiebe, M W DeGregorio, W L McGuire, C K Osborne   +3 more
core   +1 more source

Association between adjuvant tamoxifen treatment for breast cancer and subsequent cataract

Zhongguo aizheng zazhi, 2019
Background and purpose: Tamoxifen is the standard adjuvant endocrine therapy for early premenopausal hormone receptor-positive breast cancer and an important choice for postmenopausal patients. At present, the relationship between tamoxifen treatment and
陈　涵, 邵志敏, 余科达, 徐格致   +3 more
doaj  

Drug-induced liver injury secondary to tamoxifen

Tamoxifen is a non-steroidal selective oestrogen receptor modulator commonly used in the treatment of breast cancer. It is associated with the development of fatty liver and steatohepatitis however drug-induced liver injury is rare.
Murphy, Grace, Subhaharan, Deloshaan, Azer, Mary, Commins, Natalie   +3 more
core   +1 more source

Tamoxifen vs. Inhibidores de aromatasa para cáncer de mama: análisis de costo efectividad para Colombia [PDF]

, 2008
Objetivo: Evaluar el nivel de costo efectividad de la terapia con tamoxifen versus inhibidores de aromatasa en mujeres posmenopáusicas con cáncer de mama temprano receptor hormonal positivo para Colombia.
Chicaíza Becerra, Liliana, Gamboa, Óscar, García-Molina, Mario   +2 more
core  

Effect of Allicin on Tamoxifen-sensitive MCF-7 Breast Cancer Cells

Journal of Medicinal Plants, 2015
Background: One-eighth of women will develop breast cancer in their lifetime, resulting in approximately annual one million women worldwide with breast cancer. Approximately 70% of breast cancers are positive for estrogen receptor alpha (ER-).
P Rahimi-Moghaddam, H Hashemi-Setobadi, F Ghazinejhadian- Shooshtari   +2 more
doaj