Results 61 to 70 of about 125,474 (196)

Tamoxifen evolution

British Journal of Cancer, 2023
A. Howell, S. J. Howell
openaire   +2 more sources

Tamoxifen-inducible cardiac-specific disruption of Med1 (TmcsMed1^-/-) in adult mice causes dilated cardiomyopathy.

, 2016
(A) Relative Med1 mRNA expression in Med1fl/fl and TmcsMed1-/- mouse heart, liver and kidney. (B) Western blot analysis of Med1 in TmMed1fl/fl and TmcsMed1-/- hearts.
Varsha Shete (3070350), Ning Liu (168279), Philip M. Barger (3070359), Hossein Ardehali (238398), Matthew J. Schipma (2621923), Navin Viswakarma (498696), Tatsuya Sato (317466), Edward B. Thorp (3070353), Jing Liu (38537), Yi-Jun Zhu (3070356), Yuzhi Jia (498704), Bayar Thimmapaya (498705), Hsiang-Chun Chang (3070362), Yashpal S. Kanwar (25823), Janardan K. Reddy (203466)   +14 more
core   +1 more source

Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells

Journal of Experimental & Clinical Cancer Research, 2019
Background Tamoxifen resistance presents a huge clinical challenge for breast cancer patients. An understanding of the mechanisms of tamoxifen resistance can guide development of efficient therapies to prevent drug resistance.
Fujun Li, Lixia Miao, Teng Xue, Hao Qin, Santanu Mondal, Paul R. Thompson, Scott A. Coonrod, Xiaoqiu Liu, Xuesen Zhang   +8 more
doaj   +1 more source

Breast cancer chemoprevention : economic and policy considerations. [PDF]

The potential for chemoprevention of breast cancer depends on the benefits being achieved at reasonable cost. This study assesses the economics of chemoprevention of breast cancer with tamoxifen within the context of the ...
Frater, Alison
core   +1 more source

Estrogen receptor co-regulators as prognostic and predictive markers of endocrine therapy in early breast cancer: the role of SMRT and p160 family [PDF]

, 2010
Background: The estrogen receptor (ER) signaling pathway is the dominant driver of cell proliferation and survival in the majority of human breast cancers.
Migliaccio, Ilenia
core   +1 more source

Prior Adjuvant Tamoxifen Treatment in Breast Cancer Is Linked to Increased AIB1 and HER2 Expression in Metachronous Contralateral Breast Cancer.

PLoS ONE, 2016
AimThe estrogen receptor coactivator Amplified in Breast Cancer 1 (AIB1) has been associated with an improved response to adjuvant tamoxifen in breast cancer, but also with endocrine treatment resistance.
Sara Alkner, Pär-Ola Bendahl, Anna Ehinger, Kristina Lövgren, Lisa Rydén, Mårten Fernö   +5 more
doaj   +1 more source

Preventative therapies for healthy women at high risk of breast cancer [PDF]

, 2014
Ivana Sestak Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UKAbstract: Tamoxifen has been shown to reduce the risk of developing estrogen receptor (ER)-positive ...
Sestak I, Sestak, I
core   +1 more source

Risk of Parkinson's disease after tamoxifen treatment

BMC Neurology, 2010
Background Women have a reduced risk of developing Parkinson's disease (PD) compared with age-matched men. Neuro-protective effects of estrogen potentially explain this difference.
Destefano Anita L, Dybdahl Merete, Latourelle Jeanne C, Myers Richard H, Lash Timothy L   +4 more
doaj   +1 more source

Adherence to adjuvant therapy in post-menopausal breast cancer patients: A review [PDF]

, 2011
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 John Wiley & Sons, IncThis review aimed to address the concept of adherence to adjuvant therapy in post-menopausal women.
Banning, M, M. BANNING
core   +1 more source

Downregulation of miR-342 is associated with tamoxifen resistant breast tumors

Molecular Cancer, 2010
Background Tumor resistance to the selective estrogen receptor modulator tamoxifen remains a serious clinical problem especially in patients with tumors that also overexpress HER2.
Richer Jennifer K, Edgerton Susan M, Spoelstra Nicole S, Das Partha M, Cittelly Diana M, Thor Ann D, Jones Frank E   +6 more
doaj   +1 more source