Results 61 to 70 of about 122,604 (290)

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

Adherence to adjuvant therapy in post-menopausal breast cancer patients: A review [PDF]

, 2011
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 John Wiley & Sons, IncThis review aimed to address the concept of adherence to adjuvant therapy in post-menopausal women.
Banning, M, M. BANNING
core   +1 more source

Tamoxifen reduces silicone implant capsule formation in a mouse model

FASEB BioAdvances, 2022
Capsular contracture as a result of the foreign body response (FBR) is a common issue after implant‐based breast reconstruction, affecting up to 20% of patients. New evidence suggests that tamoxifen may mitigate the FBR.
Kevin M. Blum, Gabriel J. M. Mirhaidari, Jacob C. Zbinden, Christopher K. Breuer, Jenny C. Barker   +4 more
doaj   +1 more source

Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis

Advanced Science, EarlyView.
Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun, Zhensheng Yue, Zhiqiang Fang, Hao Xu, Wei Du, Yuwei Ling, Jingjing Liu, Ping Song, Fei He, Juanli Duan, Lin Wang   +10 more
wiley   +1 more source

Prevention of Breast cancer with tamoxifen:preliminary findings from the italian randomised trial among hysterectomised women [PDF]

, 1998
Prevention of breast cancer with tamoxifen: preliminary findings from the Italian randomised trial among hysterectomised women. Italian Tamoxifen Prevention Study. Veronesi U, Maisonneuve P, Costa A, Sacchini V, Maltoni C, Robertson C, Rotmensz N, Boyle
ROTMENSZ N, MAISSONNEUVE O, SACCHINI V, BOYLE P, VERONESI U, MATTONI C, PAGNI, Paola, COSTA A, ITALIAN TAMOXIFEN STUDY GROUP:, ROBERTSON C   +9 more
core   +1 more source

Calcium‐Mechanochemistry Enabled Ketone Synthesis From Organic Iodides and Carboxylic Acids

Advanced Science, EarlyView.
Mechanochemically generated organocalcium species display unusual chemoselectivity toward carboxylates, enabling direct ketone synthesis without overaddition. Ball milling activates commercial calcium metal under ambient, solvent‐minimized conditions, providing a broad substrate scope, high functional‐group tolerance, and a practical one‐step ...
Mengyao Pei, Zekun Yang, Xueyan Yang, Yufang Yang, Yangyang Shen, Jiemin Wang, Peile Ma, Zezhu Li, Xiaoliang Zheng, Xiaofeng Wei   +9 more
wiley   +1 more source

The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy

Journal of Hematology & Oncology, 2019
Background Tamoxifen resistance remains a clinical challenge for hormone receptor-positive breast cancer. Recently, dysregulations in autophagy have been suggested as a potential mechanism for tamoxifen resistance.
Ji Wang, Shuduo Xie, Jingjing Yang, Hanchu Xiong, Yunlu Jia, Yulu Zhou, Yongxia Chen, Xiaogang Ying, Cong Chen, Chenyang Ye, Linbo Wang, Jichun Zhou   +11 more
doaj   +1 more source

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Tamoxifen for prevention of breast cancer: extended long-term follow-up of the IBIS-I breast cancer prevention trial [PDF]

, 2014
© Cuzick et al. Open Access article distributed under the terms of CC BY.http://dx.doi.org/10.1016/S1470-2045(14)71171-
George, W, Lindsay, D, Eccles, D, Richmond, B, Henry, A, Mitine, C, Birrell, S, Dewar, J, Cuzick, J, Vergine, Beata, Howell, A; id_orcid, Beith, J, Fallowfield, L, Sestak, Ivana, Holli, K, Dowsett, M, Powles, T, Bird, A, Hamed, H, Cawthorn, S, Fentiman, I, Sauven, P, Cuzick, Jack, Campbell, I, Cawthorne, Simon, Holli, Kaija, Baum, M, Wilkinson, A, Wynne, C, Odling-Smee, W, Twentyman, P, Investigators, IBIS-I, Stotter, A, MacNeil, F, Collins, J P, Denton, L, Anderson, E, Abdi, E, MacMichael, K, Raytor, Z, Howell, Anthony, Buser, K, Newton, A, Blamey, R, Wilkinson, S, Godbolt, P, Ward, R, White, S, Evans, G; id_orcid, Lansdown, M, Stewart, R, Lee, M, Melmeth, A, Paksec, L, Thompson, A, Cawthorn, Simon, Forbes, J F, Chipman, M, Gebski, V, Craft, P, Atkinson, C, Earl, H, Seccombe, M, Sestak, I, Kealy, R, Forbes, JF, Boyages, J, Goldhirsch, A, Hanby, A, Hart, S, Hirst, C, Kirk, J, Mansel, R, Forbes, John F, Chapman, C, Sainsbury, R, Williamson, J, Underhill, C, Garcia, J, McAleese, P, Simes, R J, Maddox, P, Blum, R, Thornto, R, MacKay, J, Howell, A, Gilbert, F J, Hearne, J, Normand, C, Friedlander, M, Edwards, R, Pagani, O, Lennard, T, Toy, J, Robertson, J, Holcombe, C, Oivanen, T, Hamed, Hisham, Coates, A   +98 more
core   +1 more source