Results 51 to 60 of about 122,604 (290)

Tamoxifen Treatment for Riedel’s Thyroiditis: A Case Report [PDF]

, 2023
Riedel's thyroiditis is a rare variant of thyroiditis, and treatment recommendations are based on case reports. This thyroiditis form is considered among immunoglobulin G4-related diseases.
Karakılıç, Ersen, Kuyucu, Aslı, Ersen Karakılıç, Aslı Kuyucu, Saygılı, Emre Sedar, Özlem Yıldız, Yıldız, Özlem, Emre Sedar Saygılı   +7 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers [PDF]

, 2013
Introduction: We examined if a combination of proliferation markers and estrogen receptor (ER) activity could predict early versus late relapses in ER-positive breast cancer and inform the choice and length of adjuvant endocrine therapy.
Luca Gianni, Del Conte, Gianluca, Sotiriou, Christos, Pusztai, Lajos, Lajos Pusztai, Karn, Thomas, Symmans, W. Fraser, Libero Santarpia, Volkmar Müller, Santarpia, Libero, Sven Becker, Milvia Zambetti, Müller, Volkmar, Symmans, W Fraser, Benjamin Haibe-Kains, Kelly, Catherine M, Rody, Achim, Catherine M Kelly, Giampaolo Bianchini, Marcus Schmidt, Gianluca Del Conte, Gianni, Luca, Bianchini, Giampaolo, W Fraser Symmans, Haibe-Kains, Benjamin, Thomas Karn, Achim Rody, Schmidt, Marcus, Fasolo, Angelica, Takayuki Iwamoto, Angelica Fasolo, Holtrich, Uwe, Kelly, Catherine M., Yuan Qi, Christos Sotiriou, Uwe Holtrich, Iwamoto, Takayuki, Qi, Yuan, Becker, Sven, Zambetti, Milvia   +39 more
core   +2 more sources

Tamoxifen and hypercalcaemia

Annals of Oncology, 1993
The present case demonstrates the importance of close observation, also of serum calcium, when initiating tamoxifen therapy, especially in patients with known osseous metastases. Hypercalcaemia should also be considered as a possible cause of CNS symptoms in patients newly started on endocrine treatment.
openaire   +2 more sources

Risk of Retinopathy Associated with Long‐Term Use of Hydroxychloroquine in Patients with Rheumatic Diseases: A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ‐R) and its risk factors among patients receiving long‐term HCQ with rheumatic diseases through a systematic review and meta‐analysis of observational studies that used spectral‐domain optical coherence tomography (SD‐OCT) for screening ...
Narsis Daftarian, Chloe Yue, Steve D Levasseur, Hui Xie, J. Antonio Avina‐Zubieta   +4 more
wiley   +1 more source

Nano Packaged Diblock and Curcumin: a New Approach Inorder To Drug Resistance in Breast Cancer

Iranian South Medical Journal, 2017
Background: Breast cancer is one of the causes of mortality in the world. Half of patients with metastatic extend resistance to Tamoxifen and almost all patients eventually become resistant to tamoxifen. Inorder to counteract with the negative effects of
Samira Hajigholami, Ziba Vaise Malekshahi   +1 more
doaj  

Inhibition of long non-coding RNA ROR reverses resistance to Tamoxifen by inducing autophagy in breast cancer

Tumor Biology, 2017
This study explored the mechanism underlying long non-coding RNA ROR regulating autophagy on Tamoxifen resistance in breast cancer. Cancer tissues and adjacent normal tissues were collected from 74 breast cancer patients.
Yuehua Li, Baohong Jiang, Hongbo Zhu, Xiaofei Qu, Liqin Zhao, Yeru Tan, Yiling Jiang, Mingchu Liao, Xiaoping Wu   +8 more
doaj   +1 more source

Preventative therapies for healthy women at high risk of breast cancer [PDF]

, 2014
Ivana Sestak Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UKAbstract: Tamoxifen has been shown to reduce the risk of developing estrogen receptor (ER)-positive ...
Sestak I, Sestak, I
core   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

miR-449a Suppresses Tamoxifen Resistance in Human Breast Cancer Cells by Targeting ADAM22

Cellular Physiology and Biochemistry, 2018
Background/Aims: Most of estrogen receptor positive breast cancer patients respond well initially to endocrine therapies, but often develop resistance during treatment with selective estrogen receptor modulators (SERMs) such as tamoxifen.
Jun Li, Mingjie Lu, Jiao Jin, Xiyi Lu, Tongpeng Xu, Shidai Jin   +5 more
doaj   +1 more source