Results 31 to 40 of about 113,809 (305)

Disruption of the ER-α36-EGFR/HER2 positive regulatory loops restores tamoxifen sensitivity in tamoxifen resistance breast cancer cells.

PLoS ONE, 2014
Tamoxifen provided a successful treatment for ER-positive breast cancer for many years. However, most breast tumors develop tamoxifen resistance and are eventually refractory to tamoxifen therapy.
Li Yin, Xin-Tian Zhang, Xiu-Wu Bian, Yu-Ming Guo, Zhao-Yi Wang   +4 more
doaj   +1 more source

Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer

BMC Cancer, 2010
Background The cytochrome P450 (CYP) enzymes 2C19, 2D6, and 3A5 are responsible for converting the selective estrogen receptor modulator (SERM), tamoxifen to its active metabolites 4-hydroxy-tamoxifen (4OHtam) and 4-hydroxy-N-demethyltamoxifen (4OHNDtam,
Lundgren Steinar, Geisler Jürgen, Gjerde Jennifer, Ekse Dagfinn, Varhaug Jan, Mellgren Gunnar, Steen Vidar M, Lien Ernst A   +7 more
doaj   +1 more source

Upregulation of PI3K/AKT/PTEN pathway is correlated with glucose and glutamine metabolic dysfunction during tamoxifen resistance development in MCF-7 cells

Scientific Reports, 2020
Tamoxifen resistance is emerging as a big challenge in endocrine therapy of luminal A breast cancer patients. In this study, we aimed to determine the molecular changes of PI3K/AKT/PTEN signaling pathway during tamoxifen-resistance development using ...
Lama Hamadneh, Rama Abuarqoub, Ala Alhusban, Mohamad Bahader   +3 more
doaj   +1 more source

Combination treatment of tamoxifen with risperidone in breast cancer.

PLoS ONE, 2014
Tamoxifen has long been used and still is the most commonly used endocrine therapy for treatment of both early and advanced estrogen receptor-positive breast cancer in pre- and post-menopause women. Tamoxifen exerts its cytotoxic effect primarily through
Wei-Lan Yeh, Hui-Yi Lin, Hung-Ming Wu, Dar-Ren Chen   +3 more
doaj   +1 more source

CYP2D6 genotype and tamoxifen response for breast cancer: a systematic review and meta-analysis. [PDF]

, 2013
OBJECTIVE: To evaluate evidence on the association between CYP2D6 genotype and tamoxifen response through. DESIGN: Systematic review and meta-analysis of prospective, cross-sectional and case-control studies published to 2012.
Danny W. K. Lum, Perel, P, Aroon D. Hingorani (142610), Holmes, Michael V, Danny W. K. Lum (465585), Michael V. Holmes, Perel, Pablo, Holmes, MV, Aroon D Hingorani, Hingorani, AD, Michael V Holmes, Pablo Perel (102217), Hingorani, Aroon D, Danny W K Lum, Pablo Perel, Lum, Danny WK, Aroon D. Hingorani, Lum, DW, Michael V. Holmes (256443)   +18 more
core   +1 more source

Tamoxifen-injected iMfn2^DA mice exhibit impaired axonal mitochondrial transport and OXPHOS deficiency.

, 2021
(A) MitoYFP-labelled mitochondria in TH+ nerve terminals of the striatum at 3, 6 and 9 weeks after tamoxifen injection (Scale bars: 10 μm). (B) Quantificantion of mitoYFP-labelled mitochondria total intensity in the striatum of control and tamoxifen ...
Seungmin Lee (68256), Thomas Perlmann (11485872), Elena Sopova (11485866), Mara Mennuni (11485860), Viktor Jonsson (3467864), Katarína Tiklová (87618), Roberta Filograna (789459), Oleg Shupliakov (89781), Nils-Göran Larsson (106099), Camilla Koolmeister (11485869), Markus Ringnér (3876), Linda Gillberg (11485863), Lars Olson (157339)   +12 more
core   +1 more source

Tc-99m-tamoxifen: A novel diagnostic imaging agent for estrogen receptor-expressing breast cancer patients [PDF]

, 2022
PURPOSE The aim of the study was to radiolabel, characterize, and perform in vitro and in vivo assessment of Technetium-99m (Tc-99m) tamoxifen for screening ER expressing lesions in breast cancer patients.
Sharma, Uma, Upadhyay, Deepti, Vatsa, Rakhee, Mittal, Bhagwant Rai, Anupriya Chhabra, Deepti Upadhyay, Komalpreet Kaur, Jaya Shukla, Alka Bhatia, Chadha, Vijayta, Laroiya, Ishita, Bhatia, Alka, Bal, Amanjit, Vijayta Chadha, Gurpreet Singh, Kaur, Komalpreet, Shukla, Jaya, Amanjit Bal, Kumar, Rajender, Chhabra, Anupriya, Rajender Kumar, Bhagwant Rai Mittal, Singh, Gurpreet, Uma Sharma, Rakhee Vatsa, Ishita Laroiya   +25 more
core   +1 more source

Polysaccharide Peptide Extract From Coriolus versicolor Increased Tmax of Tamoxifen and Maintained Biochemical Serum Parameters, With No Change in the Metabolism of Tamoxifen in the Rat

Frontiers in Pharmacology, 2022
Background: Polysaccharide peptide (PSP) extract of Coriolus versicolor (L.) Quél. (1886) (Trametes; Polyporaceae) is increasingly used in cancer to support the immune system.
Valentina Razmovski-Naumovski, Valentina Razmovski-Naumovski, Valentina Razmovski-Naumovski, Benjamin Kimble, Daunia Laurenti, Daunia Laurenti, Srinivas Nammi, Srinivas Nammi, Hisayoshi Norimoto, Kelvin Chan, Kelvin Chan   +10 more
doaj   +1 more source

Tamoxifen Treatment for Riedel’s Thyroiditis: A Case Report [PDF]

, 2023
Riedel's thyroiditis is a rare variant of thyroiditis, and treatment recommendations are based on case reports. This thyroiditis form is considered among immunoglobulin G4-related diseases.
Karakılıç, Ersen, Kuyucu, Aslı, Ersen Karakılıç, Aslı Kuyucu, Saygılı, Emre Sedar, Özlem Yıldız, Yıldız, Özlem, Emre Sedar Saygılı   +7 more
core   +1 more source

Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer

EMBO Molecular Medicine, 2019
Resistance to tamoxifen is a clinically major challenge in breast cancer treatment. Although downregulation of estrogen receptor‐alpha (ERα) is the dominant mechanism of tamoxifen resistance, the reason for ERα decrease during tamoxifen therapy remains ...
Liping Ye, Chuyong Lin, Xi Wang, Qiji Li, Yue Li, Meng Wang, Zekun Zhao, Xianqiu Wu, Dongni Shi, Yunyun Xiao, Liangliang Ren, Yunting Jian, Meisongzhu Yang, Ruizhang Ou, Guangzheng Deng, Ying Ouyang, Xiangfu Chen, Jun Li, Libing Song   +18 more
doaj   +1 more source