Results 31 to 40 of about 122,604 (290)

Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer [PDF]

, 2010
Tamoxifen is the most widely prescribed anti-estrogen treatment for patients with estrogen receptor (ER)-positive breast cancer. However, there is still a need for biomarkers that reliably predict endocrine sensitivity in breast cancers and these may ...
Liang, Liang, J Michael Dixon, Muir, Morwenna, David A Cameron, Walker, Graeme, Sims, Andrew H., Morwenna Muir, Liang Liang, Muir, Morwenna; id_orcid, Langdon, Simon P., Dixon, J. Michael, Sims, Andrew, Taylor, Karen J., Dana Faratian, Graeme Walker, Cameron, David A., Simon P Langdon, Dixon, Mike, Karen J Taylor, Taylor, Karen J, Harrison, David J, Barbara Kuske, David J Harrison, Cameron, David A, Faratian, Dana, Kuske, Barbara, Andrew H Sims, Langdon, Simon P, Harrison, David J.   +28 more
core   +2 more sources

Effect of anastrozole on bone mineral density and lipid profiles when used to prevent breast cancer in high risk postmenopausal women [PDF]

, 2012
PhDThe role of aromatase inhibitors (AIs) in breast cancer has expanded since their introduction in the mid-1990s. They are superior to tamoxifen in the treatment of postmenopausal women with oestrogen dependant tumours in the metastatic, neoadjuvant ...
Singh, Shalini
core   +4 more sources

CYP2D6 genotype and tamoxifen response for breast cancer: a systematic review and meta-analysis. [PDF]

, 2013
OBJECTIVE: To evaluate evidence on the association between CYP2D6 genotype and tamoxifen response through. DESIGN: Systematic review and meta-analysis of prospective, cross-sectional and case-control studies published to 2012.
Danny W. K. Lum, Perel, P, Aroon D. Hingorani (142610), Holmes, Michael V, Danny W. K. Lum (465585), Michael V. Holmes, Perel, Pablo, Holmes, MV, Aroon D Hingorani, Hingorani, AD, Michael V Holmes, Pablo Perel (102217), Hingorani, Aroon D, Danny W K Lum, Pablo Perel, Lum, Danny WK, Aroon D. Hingorani, Lum, DW, Michael V. Holmes (256443)   +18 more
core   +1 more source

Tamoxifen-injected iMfn2^DA mice exhibit impaired axonal mitochondrial transport and OXPHOS deficiency.

, 2021
(A) MitoYFP-labelled mitochondria in TH+ nerve terminals of the striatum at 3, 6 and 9 weeks after tamoxifen injection (Scale bars: 10 μm). (B) Quantificantion of mitoYFP-labelled mitochondria total intensity in the striatum of control and tamoxifen ...
Seungmin Lee (68256), Thomas Perlmann (11485872), Elena Sopova (11485866), Mara Mennuni (11485860), Viktor Jonsson (3467864), Katarína Tiklová (87618), Roberta Filograna (789459), Oleg Shupliakov (89781), Nils-Göran Larsson (106099), Camilla Koolmeister (11485869), Markus Ringnér (3876), Linda Gillberg (11485863), Lars Olson (157339)   +12 more
core   +1 more source

Tamoxifen Use in a Patient with Idiopathic Macular Telangiectasia Type 2

Case Reports in Ophthalmology, 2018
Crystalline deposits and neurosensory retinal cavitary changes can develop in both tamoxifen retinopathy and nonproliferative idiopathic macular telangiectasia type 2 (MacTel2).
Alice Behrens, Ahmed Sallam, John Pemberton, Sami Uwaydat   +3 more
doaj   +1 more source

Short-term tamoxifen administration improves hepatic steatosis and glucose intolerance through JNK/MAPK in mice

Signal Transduction and Targeted Therapy, 2023
Nonalcoholic fatty liver disease (NAFLD) which is a leading cause of chronic liver diseases lacks effective treatment. Tamoxifen has been proven to be the first-line chemotherapy for several solid tumors in clinics, however, its therapeutic role in NAFLD
Zhiqiang Fang, Hao Xu, Juanli Duan, Bai Ruan, Jingjing Liu, Ping Song, Jian Ding, Chen Xu, Zhiwen Li, Kefeng Dou, Lin Wang   +10 more
doaj   +1 more source

Delayed short-term tamoxifen treatment does not promote remyelination or neuron sparing after spinal cord injury.

PLoS ONE, 2020
The tamoxifen-dependent Cre/lox system in transgenic mice has become an important research tool across all scientific disciplines for manipulating gene expression in specific cell types.
Nicole Pukos, Dana M McTigue
doaj   +1 more source

Tamoxifen suppresses pancreatic β-cell proliferation in mice.

PLoS ONE, 2019
Tamoxifen is a mixed agonist/antagonist estrogen analogue that is frequently used to induce conditional gene deletion in mice using Cre-loxP mediated gene recombination.
Surl-Hee Ahn, Anne Granger, Matthew M Rankin, Carol J Lam, Aaron R Cox, Jake A Kushner   +5 more
doaj   +1 more source

Plasma rich-platelet (PRP) potentially attenuates tamoxifen spermatogenic dysfunction in rat's model: sperm quality, histomorphometric, and apoptosis assessment [PDF]

Asia Pacific Journal of Medical Toxicology
Background: Tamoxifen induces testicular atrophy and azoospermia. Conversely, platelet-rich plasma (PRP) is a distinctive analog yield enriched with cytokines and growth factors for improving tissue regeneration.
Hossein Hamali, Fatemeh Masoumi, Behzad Baradaran, Gholamreza Hamidian   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source