Results 11 to 20 of about 113,809 (305)
Journal of Mazandaran University of Medical Sciences, 2005 Background and purpose: Chronic anovulation is a common cause of infertility in women. Most women with chronic anoulation have irregular menstural cycles and normal serum FSH concentration s(WHO-type 2).finding out influential factors on ovarian ...
T. Madani +3 more
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Unveiling the Impact of Morphine on Tamoxifen Metabolism in Mice in vivo
Frontiers in Oncology, 2020 Background: Tamoxifen is used to treat breast cancer and cancer recurrences. After administration, tamoxifen is converted into two more potent antitumor compounds, 4OH-tamoxifen and endoxifen by the CYP3A4/5 and 2D6 enzymes in human.
Florian Gabel +9 more
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Saudi Pharmaceutical Journal, 2020 Consumption of Cytochrome P450 2D6 (CYP2D6) inhibiting drugs along with tamoxifen treatment results in decrease in plasma concentration of endoxifen, the major active tamoxifen metabolite.
Azher Arafah +5 more
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BMC Endocrine Disorders, 2021 Background Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare.
Hayato Isobe +11 more
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Behavioral and transcriptomic effects of the cancer treatment tamoxifen in mice
Frontiers in Neuroscience, 2023 IntroductionTamoxifen is a common treatment for estrogen receptor-positive breast cancer. While tamoxifen treatment is generally accepted as safe, there are concerns about adverse effects on cognition.MethodsWe used a mouse model of chronic tamoxifen ...
Elena Galvano +7 more
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Impact of Irradiation on the Pharmacokinetics and Biotransformation of Tamoxifen
Frontiers in Oncology, 2022 BackgroundThe optimal procedure for combining radiotherapy (RT) with tamoxifen treatment is controversial as RT may alter the pharmacokinetics and biotransformation of tamoxifen.
Yung-Yi Cheng +14 more
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Relationship between genotypes Sult1a2 and Cyp2d6 and tamoxifen metabolism in breast cancer patients. [PDF]
PLoS ONE, 2013 Tamoxifen is a pro-drug widely used in breast cancer patients to prevent tumor recurrence. Prior work has revealed a role of cytochrome and sulfotransferase enzymes in tamoxifen metabolism.
Ana Fernández-Santander +7 more
doaj +1 more source
NR4A1 Regulates Tamoxifen Resistance by Suppressing ERK Signaling in ER-Positive Breast Cancer
Cells, 2021 Endocrine therapy is used to treat estrogen receptor (ER)-positive breast cancer. Tamoxifen is effective against this cancer subtype. Nonetheless, approximately 30% of patients treated with tamoxifen acquire resistance, resulting in therapeutic ...
Yu Cheon Kim +3 more
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Cohort study examining tamoxifen adherence and its relationship to mortality in women with breast cancer [PDF]
, 2008 Increasing duration of tamoxifen therapy improves survival in women with breast cancer but the impact of adherence to tamoxifen on mortality is unclear. This study investigated whether women prescribed tamoxifen after surgery for breast cancer adhered to
Crilly, M. +17 more
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Tamoxifen and the uterus [PDF]
BMJ, 1994 The effects of tamoxifen on the endometrium have caused concern since the late 1980s,1,2 and clear evidence of endometrial changes has now emerged from three studies in postmenopausal women - one case-control study of breast cancer3 and two randomised controlled trials, one in women with early breast cancer4 and one in healthy women with a family ...
P, Neven +4 more
openaire +5 more sources