Results 21 to 30 of about 122,604 (290)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model. [PDF]

Mol Oncol
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Schwarzmüller L, Müller J, Vlachavas EI, Beumers L, Fleischhacker L, Burmester S, Wörner A, Karolus S, Helm D, Körner C, Wiemann S.   +10 more
europepmc   +2 more sources

Long-Term Use of Tamoxifen Is Associated With a Decreased Subsequent Meningioma Risk in Patients With Breast Cancer: A Nationwide Population-Based Cohort Study

Frontiers in Pharmacology, 2019
Background: Earlier studies have indicated a relatively higher risk of occurring meningioma among female breast cancer survivors and have suggested that tamoxifen might decrease this risk.
Li-Min Sun, Cheng-Li Lin, Cheng-Li Lin, Sean Sun, Chung Y. Hsu, Zonyin Shae, Chia-Hung Kao, Chia-Hung Kao, Chia-Hung Kao   +8 more
doaj   +1 more source

Upregulation of PI3K/AKT/PTEN pathway is correlated with glucose and glutamine metabolic dysfunction during tamoxifen resistance development in MCF-7 cells

Scientific Reports, 2020
Tamoxifen resistance is emerging as a big challenge in endocrine therapy of luminal A breast cancer patients. In this study, we aimed to determine the molecular changes of PI3K/AKT/PTEN signaling pathway during tamoxifen-resistance development using ...
Lama Hamadneh, Rama Abuarqoub, Ala Alhusban, Mohamad Bahader   +3 more
doaj   +1 more source

Combination treatment of tamoxifen with risperidone in breast cancer.

PLoS ONE, 2014
Tamoxifen has long been used and still is the most commonly used endocrine therapy for treatment of both early and advanced estrogen receptor-positive breast cancer in pre- and post-menopause women. Tamoxifen exerts its cytotoxic effect primarily through
Wei-Lan Yeh, Hui-Yi Lin, Hung-Ming Wu, Dar-Ren Chen   +3 more
doaj   +1 more source

Polysaccharide Peptide Extract From Coriolus versicolor Increased Tmax of Tamoxifen and Maintained Biochemical Serum Parameters, With No Change in the Metabolism of Tamoxifen in the Rat

Frontiers in Pharmacology, 2022
Background: Polysaccharide peptide (PSP) extract of Coriolus versicolor (L.) Quél. (1886) (Trametes; Polyporaceae) is increasingly used in cancer to support the immune system.
Valentina Razmovski-Naumovski, Valentina Razmovski-Naumovski, Valentina Razmovski-Naumovski, Benjamin Kimble, Daunia Laurenti, Daunia Laurenti, Srinivas Nammi, Srinivas Nammi, Hisayoshi Norimoto, Kelvin Chan, Kelvin Chan   +10 more
doaj   +1 more source

Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer

EMBO Molecular Medicine, 2019
Resistance to tamoxifen is a clinically major challenge in breast cancer treatment. Although downregulation of estrogen receptor‐alpha (ERα) is the dominant mechanism of tamoxifen resistance, the reason for ERα decrease during tamoxifen therapy remains ...
Liping Ye, Chuyong Lin, Xi Wang, Qiji Li, Yue Li, Meng Wang, Zekun Zhao, Xianqiu Wu, Dongni Shi, Yunyun Xiao, Liangliang Ren, Yunting Jian, Meisongzhu Yang, Ruizhang Ou, Guangzheng Deng, Ying Ouyang, Xiangfu Chen, Jun Li, Libing Song   +18 more
doaj   +1 more source

Tamoxifen inhibits TGF-β/Smad pathway and reduces pathological proliferation of human dermal fibroblasts [PDF]

Jichu yixue yu linchuang, 2022
Objective To explore the function and mechanism of tamoxifen, an estrogen receptor modulator, in the pathogenesis of hyperplatic scar. Methods Primary human fibroblasts were isolated and cultured for 4 generations and then aliquated into 3 groups ...
SHI Chun-tian, MAO Shu-ran, PENG Yi-xuan, XIAO Zhi-bo
doaj   +1 more source

A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen [PDF]

, 2012
SynthSys is a Centre for Integrative Systems Biology (CISB) funded by BBSRC and EPSRC, reference BB/D019621/1.Background: Estrogen receptors alpha (ER) are implicated in many types of female cancers, and are the common target for anti-cancer therapy ...
Harrison, David J, Kenneth Macleod, Yamaguchi, Azusa, Macleod, Kenneth, Galina Lebedeva, David J Harrison, Lebedeva, Galina, Langdon, Simon P., Langdon, Simon P, Azusa Yamaguchi, Harrison, David J., Simon P Langdon   +11 more
core   +1 more source

Tamoxifen-induced limb and craniofacial malformations.

, 2021
Along with representative vehicle controls of forelimb (a), hindlimb (f), and palate (i’), examples of malformations in forelimbs (b-e), hindlimbs (g, h), and palate (j’) of 200 mg/kg tamoxifen-treated animals are shown at GD17.
Austin C. Steward (11285743), Miranda R. Sun (9467987), Alexander A. Martin (11285746), Emma A. Sweet (4252480), Robert J. Lipinski (9468002)   +4 more
core   +1 more source

CXCR4 Antagonist AMD3100 Reverses the Resistance to Tamoxifen in Breast Cancer via Inhibiting AKT Phosphorylation

Molecular Therapy: Oncolytics, 2020
Endocrine therapy is a systemic therapy and has become the main treatment strategy for patients with estrogen receptor (ER)-positive breast cancer.
Jun Zhou, Kehao Le, Ming Xu, Jie Ming, Wen Yang, Qiulei Zhang, Linlin Lu, Zihan Xi, Shengnan Ruan, Tao Huang   +9 more
doaj   +1 more source