Results 21 to 30 of about 113,809 (305)
Frontiers in Oncology, 2022 Acquired resistance is a major clinical challenge for tamoxifen-based therapy. In this study, we focused on lncRNA SNHG6 which plays a role in chemoresistance of cancer cells, but has never been investigated in the context of tamoxifen resistance.
Mohammad Imran Khan +2 more
doaj +1 more source
Italian randomized trial among womenwith histerectomy: tamoxifen and hormone-dependent breast cancer in hight-risk women [PDF]
, 2003 Tamoxifen improves outcome in women with breast cancer and reduces the incidence of estrogen receptor-positive (ER+) breast tumors in prevention trials. Tamoxifen use is associated with an increased risk of potentially serious adverse events, principally
MAISSONEUVE P +5 more
core +1 more source
Breast Cancer Research, 2019 Background High background parenchymal uptake (BPU) on molecular breast imaging (MBI) has been identified as a breast cancer risk factor. We explored the feasibility of offering a short-term intervention of low-dose oral tamoxifen to women with high BPU ...
Carrie B. Hruska +8 more
doaj +1 more source
Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia
Animal Welfare, 2023 Tamoxifen-induced CreER-LoxP recombination is often used to induce spatiotemporally controlled gene deletion in genetically modified mice. Prior work has shown that tamoxifen and tamoxifen-induced CreER activation can have off-target effects that should ...
Victoria S Rashbrook +2 more
doaj +1 more source
Cancer Medicine, 2020 Tamoxifen‐based hormone therapy is central for the treatment of estrogen receptor positive (ER+) breast cancer. However, the acquired tamoxifen resistance, typically co‐exists with hypoxia, remains a major challenge.
Ying Li +10 more
doaj +1 more source
A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen [PDF]
, 2012 SynthSys is a Centre for Integrative Systems Biology (CISB) funded by BBSRC and EPSRC, reference BB/D019621/1.Background: Estrogen receptors alpha (ER) are implicated in many types of female cancers, and are the common target for anti-cancer therapy ...
Harrison, David J +11 more
core +1 more source
Tamoxifen-induced limb and craniofacial malformations.
, 2021 Along with representative vehicle controls of forelimb (a), hindlimb (f), and palate (i’), examples of malformations in forelimbs (b-e), hindlimbs (g, h), and palate (j’) of 200 mg/kg tamoxifen-treated animals are shown at GD17.
Austin C. Steward (11285743) +4 more
core +1 more source
Breast cancer chemoprevention : economic and policy considerations. [PDF]
, 2004 The potential for chemoprevention of breast cancer depends on the benefits being achieved at reasonable cost. This study assesses the economics of chemoprevention of breast cancer with tamoxifen within the context of the ...
Frater, Alison
core +2 more sources
Frontiers in Pharmacology, 2019 Background: Earlier studies have indicated a relatively higher risk of occurring meningioma among female breast cancer survivors and have suggested that tamoxifen might decrease this risk.
Li-Min Sun +8 more
doaj +1 more source
Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer [PDF]
, 2010 Tamoxifen is the most widely prescribed anti-estrogen treatment for patients with estrogen receptor (ER)-positive breast cancer. However, there is still a need for biomarkers that reliably predict endocrine sensitivity in breast cancers and these may ...
Liang, Liang +28 more
core +1 more source