Results 171 to 180 of about 122,604 (290)

Signal Detection and Pharmacovigilance Analysis of Tamoxifen, Clomiphene, and Letrozole in Polycystic Ovarian Syndrome: A FAERS Database Study. [PDF]

Int J Womens Health
Zhang D, Zhou J.
europepmc   +1 more source

CDK4/6 Inhibitors in the Management of Hormone Receptor‐Positive (HR+)/Human Epidermal Growth Factor Receptor 2‐Negative (HER2−) Advanced Breast Cancer in Indonesia: Challenges, Opportunities, and Recommendations

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Evidence‐informed recommendations emphasize the integration of CDK4/6 inhibitors with endocrine therapy as a central component in the management of HR+/HER2− advanced breast cancer in Indonesia. Expanding access and facilitating integration within national treatment frameworks are crucial to improve outcomes and reduce disparities in care.
Sonar Soni Panigoro, Samuel J. Haryono, Prihantono Prihantono, Dedy Hermansyah, Sumadi Lukman Anwar, Yohana Azhar, Febriyanto Kurniawan, Putu Anda Tusta Adiputra, Kristanto Yuli Yarso, Asdi Wihandono   +9 more
wiley   +1 more source

Leveraging endocrine sensitivity in ER-positive DCIS: Neoadjuvant therapy and nonoperative management. [PDF]

Breast
Semba R, Childs S, Saw K, Segara D, Mann GB, Shien T, Birrell S, Horimoto Y, Kutomi G, Lim E.   +9 more
europepmc   +1 more source

Age-related hearing loss persisted in mice that had demonstrated improved healthspan, reduced inflammaging and extended lifespan following expression of the naked mole-rat transgene for hyaluronan synthase 2. [PDF]

Front Aging
Owens CE, Borruso AJ, Place KA, Seluanov A, Gorbunova V, White PM, Place NJ.   +6 more
europepmc   +1 more source

Clinical Relevance of the SOUND and INSEMA Trials in Women With Early Breast Cancer in Australia and New Zealand

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Axillary surgery in breast cancer has undergone progressive de‐escalation. The recent Sentinel Node versus Observation after Axillary Ultrasound (SOUND) and Intergroup Sentinel Mamma (INSEMA) trials have demonstrated that sentinel lymph node biopsy may be safely omitted in selected patients. This study aimed to evaluate the clinical
Matea Dominkovic, Kerry Hitos, Wei Wang, T. Michael Hughes, James French, Nicholas Ngui   +5 more
wiley   +1 more source

Tamoxifen induces region-specific osteocytic recombination and transiently alters bone structure in Dmp1-Cre-ERT2 mice. [PDF]

J Biol Chem
Koh NY, Wee NK, McGregor NE, Poulton IJ, Kuropatkina M, Maes C, Sims NA.   +6 more
europepmc   +1 more source

Menopausal status at the age of 46: Its association with depressive and anxiety symptoms and morbidity in women—A northern Finland birth cohort 1966 study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Women who are perimenopausal or menopausal at age 46 have a higher risk of anxiety and depressive symptoms than premenopausal women. Early‐onset menopause highlights the need for mental health support during and after the menopausal transition. Abstract Introduction The incidence of several morbidities increases during the menopausal transition ...
Tiia Saarinen, Susanna M. Savukoski, Paula Pesonen, Jouko Miettunen, Maarit Niinimäki   +4 more
wiley   +1 more source

Tamoxifen therapy benefit in luminal A and B breast cancer with 20-year follow-up. [PDF]

J Natl Cancer Inst
Danielsson O, Dar H, Nordenskjöld A, Perez-Tenorio G, Nordenskjöld B, Fornander T, Stål O, Tobin NP, Tutzauer J, Johansson A, Lindström LS.   +10 more
europepmc   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Targeting Estrogen Receptor for Breast Cancer. [PDF]

Curr Issues Mol Biol
Yiannakopoulou E.
europepmc   +1 more source