Results 181 to 190 of about 122,604 (290)

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

Active Peyronie's disease as an early antifibrotic treatment window: a translational review. [PDF]

Sex Med
Broul M, Liegertová M, Hujová A, Vostrý M.   +3 more
europepmc   +1 more source

MEN1 Deficiency Drives Lung Cancer Progression via Activation of MMP10‐Mediated Angiogenesis

Cancer Science, EarlyView.
MEN1 deficiency promotes JunD‐mediated upregulation of MMP10 expression, which cleaves pro‐HB‐EGF and activates endothelial EGFR. This triggers the PI3K/Akt and MEK/ERK signaling pathways, thereby driving angiogenesis and tumor progression. MMP10 inhibitor treatment blocks this cleavage, suppresses EGFR signaling, and thereby delays malignant ...
Chengyu Wei, Xiangyu Liu, Shimin Hu, Xiaodie Shen, Yingli Liu, Xinxin Qin, Ye Zhou, Jianqi Zheng, Bingke Tian, Jingfang Hong, Yongxia Song, Di Wang, Linlin Peng, Jinxia Ding, Fang Wang, Hui Zhang, Shihao Zhang, Huan Qiu   +17 more
wiley   +1 more source

Inhibited oligodendrogenesis impairs attention and motivation in adult mice regardless of repeated mild traumatic brain injury. [PDF]

Front Behav Neurosci
Gazdzinski LM, Mak J, Mellerup M, Fletcher PJ, Wheeler AL.   +4 more
europepmc   +1 more source

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh, Nathalie Vermeulen, Carolyn Ee, Helena Teede, Amanda J. Vincent   +4 more
wiley   +1 more source

Impact of adjuvant endocrine therapy on disease-free survival in early triple-positive breast cancer: a multicenter retrospective cohort study of the Turkish oncology group. [PDF]

BMC Cancer
Seyyar M, Şancı PC, Doğan A, Biter S, Köşeci T, Balçık OY, Karabel SS, Kalem A, Akosman C, Pilancı KN, Onur İD, Arslan ÜY, Kemal Y, Avcı T, Şahbazlar M, Akay S, Kahraman EG, Bayramgil A, Altıntaş YE, Tünbekici S, Göker E, Çolak C, Demir T, Demirağ G, Güneysu GG, Aykan MB, Nazlı İ, Alkan O, Ökten İN, Çolak R, Yılmaz M, Gür HB, Hacıbekiroğlu İ, Sönmez M, Özyurt N, Aydın O, Ertürk K, Şahin E, Karakayalı A, Baydar E, Çıtakkul İ, Emin G, Yıldırım A, Gülmez A, Özberk U, Algın E, Köseoğlu Ç, Uzundere FK, Urakçı Z, Akpunar M, Alkan A, Süner A, Peker P, Camadan YA, Can LŞ, Telli TA, Majidova N, Uzun M, Özkan MK, Baykara M, Güzel HG, Yıldırım HÇ, Kefeli U, Çabuk D, Kus T.   +64 more
europepmc   +1 more source

Current Approaches to Support Patients to Withdraw From Image and Performance Enhancing Drugs

Clinical Endocrinology, EarlyView.
ABSTRACT Image and performance‐enhancing drugs (IPEDs) include agents such as androgens, growth hormone, and erythropoietin, which are used to enhance appearance and physical performance. Androgens, also known as anabolic‐androgenic steroids (AAS), are the most used IPEDs worldwide.
Elizabeth Hyams, Bonnie Grant, Richard Quinton, Channa N. Jayasena   +3 more
wiley   +1 more source

Resolving CYP2D6 Structural Complexity with Long-Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients. [PDF]

Clin Pharmacol Ther
Boonyuen U, Talukam S, Jacob BAC, Matphong W, Chamchoy K, Reamtong O, Meesiripan N, Yamagishi J, Phanchana M, Rattadilok C.   +9 more
europepmc   +1 more source

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Early detection of tamoxifen-induced retinal injury: ellipsoid zone reflectivity as a sensitive structural marker. [PDF]

BMC Ophthalmol
Unlu BH, Koksaldı S, Durmaz Engin C, Varol U.   +3 more
europepmc   +1 more source