Results 211 to 220 of about 113,809 (305)

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
wiley   +1 more source

CAFs and Endocrine Therapy Resistance in Hormone Receptor-Positive Breast Cancer. [PDF]

Int J Mol Sci
Sofianidi AA, Stafyla VK, Zagouri F.
europepmc   +1 more source

Deciphering the Functional Mechanisms of eIF3f in Tumors and Exploring Targeted Therapies

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Eukaryotic translation initiation factor 3 subunit F (eIF3f) is a critical component of the eIF3 complex and plays a pivotal role in diverse biological processes, including cell proliferation, apoptosis, adhesion, and transcriptional regulation.
Yujinpeng Hao, Jun Shao, Naqi Lian, Mianli Bian   +3 more
wiley   +1 more source

Sex-Dependent Diabetes Impact of Acute Grp78 Deletion in β-Cells of Adult Mice. [PDF]

Diabetes
Burton JJN, Castro TA, Juray AA, Hassan HA, Diaz Mosquea H, Sharma RB, Alonso LC.   +6 more
europepmc   +1 more source

Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow. [PDF]

Elife
Feng JX, Yang MT, Li L, Li CC, Livak F, Chen J, Zhao Y, Wang D, Bhandoola A, Taylor N, Tosato G.   +10 more
europepmc   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Endocrine therapy reprogramming of breast cancer facilitates metastatic escape via upregulation of P-Rex1/Rac1 signalling. [PDF]

Nat Commun
Fernandez KJ, Sultani G, Nobis M, Gloss B, Eshraghi L, McCart Reed AE, Alexandrou S, Lee C, Roden DL, Jones EI, Simad MH, Millar EKA, Bartonicek N, Oakes SR, Valdes-Mora F, Colino-Sanguino Y, Mok ETY, Williams HL, Kutasovic JR, Cummings MC, Stoehr J, Lee V, Harvey K, Wu S, Lakhani SR, Simpson PT, Cox TR, Ooms LM, Mitchell CA, Salomon R, Swarbrick A, Gallego-Ortega D, Lim E, Timpson P, Caldon CE.   +34 more
europepmc   +1 more source

Oestrogen receptor phosphorylation profiles and in silico PAM50 subtyping reflect sexual dimorphism in breast cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Breast cancer (BC) is most prevalent in females but also accounts for <1% of male cancer cases and 0.2% of male cancer‐related deaths. Distribution of histological subtypes, receptor status, and age of diagnosis varies based on sex, and a growing body of evidence supports sex‐specific molecular differences in BC.
Subarnarekha Chatterji, Aimee Diack, Marcin Szostok, Michael D Morgan, Valentina Silvestri, Laura Ottini, Cathy B Moelans, Paul J van Diest, Cigdem Selli, Andrew H Sims, Rasha Abu‐Eid, Valerie Speirs   +11 more
wiley   +1 more source

Tamoxifen Combined with Hormone Replacement in Women with Thin Endometrium Receiving Frozen-Thawed Embryo Transfer for Promoting Endometrial Growth: A Double-Blinded, Randomized Controlled Trial. [PDF]

Int J Gen Med
Shi Q, Mei J, Yan G, Kong N, Liu J, Shen X, Sun Y, Lu F, Jiang Y, Sun H, Huang C.   +10 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, Volume 16, Issue 7, Page 1400-1413, July 2026.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source