Results 201 to 210 of about 113,809 (305)

Voltage‐gated potassium channels mediate thyroid hormone control of skeletal muscle excitability

The Journal of Physiology, EarlyView.
Abstract figure legend Thyroid hormone (TH)‐dependent remodelling of potassium (K+) channel networks regulates skeletal muscle (SkM) excitability. Triiodothyronine (T3), locally generated from thyroxine (T4) by type 2 deiodinase (D2), binds thyroid hormone receptors (TRα/β) and modulates transcription via thyroid response elements (TREs).
Annarita Nappi, Caterina Miro, Annunziata Gaetana Cicatiello, Ilaria Piccialli, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Rosa Sirica, Melania Murolo, Emery Di Cicco, Daniela Terracciano, Anna Pannaccione, Monica Dentice   +12 more
wiley   +1 more source

Epithelial cell expansion drives cyst progression in genetic models of autosomal recessive polycystic kidney disease. [PDF]

iScience
Liu S, Chen X, Liu Z, Tang J, Tian H, Peng Y, Mao X, Dai R, Zhao B, Li X, Li L, Luo L, Ma M.   +12 more
europepmc   +1 more source

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

VMP1 forms a Ca²⁺ release channel essential for postnatal heartbeat. [PDF]

Sci Adv
Ma Y, Li Q, Jia Y, Hao B, Li J, Zhang Z, Yin N, Fang S, Wang Y, Wu Z, Gao Z, Xia B, Peng M.   +12 more
europepmc   +1 more source

The Predictive Value of the Tumor‐Stroma Ratio for Neoadjuvant Endocrine Therapy in Hormone Receptor‐Positive Breast Cancer

International Journal of Cancer, Volume 159, Issue 4, Page 1056-1067, 15 August 2026.
Neoadjuvant endocrine therapy (NET) can help prevent metastases and improve survival in patients with hormone receptor‐positive (HR+) breast cancer. Identifying which HR+ patients will benefit from NET, however, remains challenging. Here, in a patient cohort in the Netherlands, the authors evaluated tumor‐stroma ratio (TSR) and magnetic resonance ...
Layla Andour, Sophie C. Hagenaars, Anne Florine de Groot, Elly M. M. Krol‐Warmerdam, Judith R. Kroep, Hans Marten Hazelbag, Gerrit‐Jan Liefers, Marieke E. Straver, Wilma E. Mesker   +8 more
wiley   +1 more source

Effect of VSOR/VRAC blocker tamoxifen on contractile activity of primary neonatal cardiomyocytes and isolated perfused heart. [PDF]

BMC Res Notes
Maksimcheva GV, Oljaev ND, Mansurov MM, Fayziev DD, Tsiferova NA, Merzlyak PG, Kurbannazarova RS, Abdullaev IF, Sabirov RZ.   +8 more
europepmc   +1 more source

Female Mice Show Stronger Time‐of‐Day Modulation of Astrocytic Ca2+ Activity in the Sleep‐Regulatory Ventrolateral Preoptic Nucleus

Glia, Volume 74, Issue 8, August 2026.
VLPO astrocytes exhibit sex‐specific Ca2+ dynamics across the nycthemeral cycle. Males show faster Ca2+ kinetics, while females display increased amplitude, frequency, and network coupling at Zeitgeber Time (ZT)‐14. Sex is a key variable in astrocyte‐based sleep regulation mechanisms.
Félix Camille Bellier, Lou Zonca, David Holcman, Frédéric Chauveau, Nathalie Rouach, Armelle Rancillac   +5 more
wiley   +1 more source

Tamoxifen-induced neutropenia and leukopenia in a breast cancer patient: a case report and literature review. [PDF]

Front Oncol
Liu C, Xu F, Liu Q.
europepmc   +1 more source

Sphingosine‐1‐Phosphate Receptor 1 Promotes Ovarian Cancer Tumorsphere Proliferation and Metastasis

International Journal of Cancer, Volume 159, Issue 3, Page 768-781, 1 August 2026.
In high‐grade serous ovarian cancer, malignant ascites frequently arise as ovarian cancer cells shed from the primary tumor and aggregate into tumorspheres, severely limiting treatment success. To date, little is known about the mechanisms governing tumorsphere endurance and metastasis within the ascites once formed.
Núria Gendrau‐Sanclemente, Agnès Figueras, Ferran Medina‐Jover, Juan A. Marín‐Jiménez, Michelle De Leeuw, Tianyu Dai, Marina Moreno‐Mosquera, Andrea Morales, Marc Guiu, Josefina Casas, José Carlos Perales, Roger R. Gomis, Francesc Viñals   +12 more
wiley   +1 more source

The Evolution of Targeted Therapies in Early Hormone Receptor-Positive, HER2-Negative Breast Cancer. [PDF]

Cancers (Basel)
Ohm H, Lohrisch C, LeVasseur N, Simmons C, Mitri ZI.   +4 more
europepmc   +1 more source