Results 91 to 100 of about 70,211 (203)

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer [PDF]

, 2017
In a previous study, we detected a significant association between phosphoserine aminotransferase 1 (PSAT1) hyper-methylation and mRNA levels to outcome to tamoxifen treatment in recurrent disease.
Deurzen, C.H.M. (Carolien) van, Foekens, J.A. (John), Grebenchtchikov, N. (Nicolai), Look, M.P. (Maxime), Magdolen, V., Marchi, T. (Tommaso) de, Martens, J.W.M. (John), Sieuwerts, A.M. (Anieta), Smid, M. (Marcel), Smits, J.G. (Jan G.), Sweep, F.C. (Fred), Timmermans, A.M. (Mieke), Umar, A. (Arzu)   +12 more
core   +1 more source

Everolimus plus exemestane in postmenopausal patients with HR(+) breast cancer: BOLERO-2 final progression-free survival analysis. [PDF]

, 2013
IntroductionEffective treatments for hormone-receptor-positive (HR(+)) breast cancer (BC) following relapse/progression on nonsteroidal aromatase inhibitor (NSAI) therapy are needed. Initial Breast Cancer Trials of OraL EveROlimus-2 (BOLERO-2) trial data
Arena, Francis P, Baselga, José, Burris, Howard A, Cahana, Ayelet, Campone, Mario, Erdkamp, Frans, Feng, Wentao, Gnant, Michael, Harb, Wael A, Hortobagyi, Gabriel N, Lebwohl, David, Melichar, Bohuslav, Noguchi, Shinzaburo, Petrakova, Katarina, Piccart, Martine, Pistilli, Barbara, Pritchard, Kathleen I, Rugo, Hope S, Taran, Tetiana, Yardley, Denise A   +19 more
core   +2 more sources

A Role for Estrogen Receptor Phosphorylation in the Resistance to Tamoxifen

International Journal of Breast Cancer, 2011
About two thirds of all human breast cancer cases are estrogen receptor positive. The drug of first choice for these patients is tamoxifen.
Renée de Leeuw, Jacques Neefjes, Rob Michalides   +2 more
doaj   +1 more source

The role of Nanog expression in tamoxifen-resistant breast cancer cells [PDF]

, 2015
There is an accumulation of evidence that shows a significant role of cancer stem cells in tumor initiation, proliferation, relapse, and metastasis. Nanog is the most important core transcription marker of stem cells, known by its role in maintaining ...
Arif, Khalid, El-Sheemy, Mohamed, Hussain, Issam, Rea, Carol   +3 more
core   +2 more sources

Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells. [PDF]

, 2017
p53 deletion prevents the embryonic lethality of normal tissues lacking Mdm2, suggesting that cells can survive without Mdm2 if p53 is also absent.
Adams, Clare M., Eischen, Christine M., Feeley, Kyle P, Mitra, Ramkrishna   +3 more
core   +1 more source

Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity

Cell Reports, 2015
Breast cancers (BCs) typically express estrogen receptors (ERs) but frequently exhibit de novo or acquired resistance to hormonal therapies. Here, we show that short-term treatment with the anti-estrogens tamoxifen or fulvestrant decrease cell ...
Bruno M. Simões, Ciara S. O’Brien, Rachel Eyre, Andreia Silva, Ling Yu, Aida Sarmiento-Castro, Denis G. Alférez, Kath Spence, Angélica Santiago-Gómez, Francesca Chemi, Ahmet Acar, Ashu Gandhi, Anthony Howell, Keith Brennan, Lisa Rydén, Stefania Catalano, Sebastiano Andó, Julia Gee, Ahmet Ucar, Andrew H. Sims, Elisabetta Marangoni, Gillian Farnie, Göran Landberg, Sacha J. Howell, Robert B. Clarke   +24 more
doaj   +1 more source

Ras hyperactivation versus overexpression : Lessons from Ras dynamics in Candida albicans [PDF]

, 2018
We thank Prof. Neta Dean for the CIp10ADH1-Cherry plasmid and Prof. Aaron Mitchell for the BWP17 strain. We gratefully acknowledge Prof. Sudipta Maiti, TIFR, Mumbai, India for providing the data acquisition software.
Haokip, Dominic T, Jain, Priyanka, Khan, Mohammad Firoz, Komath, Sneha Sudha, Pal, Nibedita, Pratyusha, Vavilala A, Sen, Sobhan, Sethi, Subhash Chandra, Singh, Sneh Lata, Victoria, Guiliana Soraya, Yadav, Bhawna   +10 more
core   +3 more sources

Targeting lipid metabolism to overcome tamoxifen resistance in breast cancer: Evaluating the synergistic therapeutic potential of quercetin

Cancer Treatment and Research Communications
Breast cancer remains the most prevalent malignancy among women globally, with hormone receptor-positive subtypes representing the majority of cases. Despite significant advances in treatment, resistance to Tamoxifen, a cornerstone therapy for estrogen ...
Radwa M. Rifaat, Marwa W. Kamel, Marwa Sharaky, Yasmin M. Attia, Samia A. Shouman   +4 more
doaj   +1 more source

Tamoxifen Resistant Breast Cancer and Autophagy

, 2011
1.1 Tamoxifen for the treatment of breast cancer Tamoxifen was originally developed with the hope of becoming a “morning after” contraceptive. During the 1960s, studies showed that tamoxifen and other anti-estrogens have a profound impact on the fertility of laboratory rats and it was believed that tamoxifen could elicit the same effects in humans ...
Wilkinson, Grey A., Elwi, Adam N., Kim, Sung-Woo   +2 more
openaire   +3 more sources

Kurkumin Meningkatkan Sensitivitas Sel Kanker Payudara terhadap Tamoksifen Melalui Penghambatan Ekspresi P-glikoprotein dan Breast Cancer Resistance Protein

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2018
The decreasing of sensitivity or resistance to tamoxifen occured after long-term treatment in breast cancer. One of the major factor in tamoxifen resistance is over expression of efflux transporter P-glycoprotein (P-gp) and Breast Cancer Resistance ...
Erlia Anggrainy Sianipar, Melva Louisa, Septelia Inawati Wanandi   +2 more
doaj   +1 more source