Results 131 to 140 of about 250 (209)

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Canada's Ethics Commissioner and the Watchdog Model of Ethics Enforcement

Canadian Public Administration, EarlyView.
Abstract Despite notable progress, the OECD recently noted that conflict of interest regulation still suffers from poor implementation and how to ensure effective enforcement of ethics rules remains an important challenge. One popular but under‐examined approach is to rely on an ethics watchdog: an independent agency with few powers that can ...
Luc Juillet
wiley   +1 more source

Survey on Visualization of Information Diffusion over Networks

Computer Graphics Forum, EarlyView.
Abstract Information Diffusion (ID) describes how a value (e.g., a pathogen, a rumor, a packet) spreads through an underlying “medium” network of elements (e.g., a social or computer network). Understanding the information diffusion process is essential to predicting trends, controlling misinformation, and enhancing decision‐making as well as ...
T. Baumgartl, M. Sondag, V. Filipov, M. Tuscher, S. Rajendran, S. Miksch, D. Archambault, A. Arleo, T. von Landesberger   +8 more
wiley   +1 more source

SiGnature: Explicit Motion Diffusion for Stylized Semantic Gesture Generation

Computer Graphics Forum, EarlyView.
Abstract While recent advances in co‐speech gesture generation have achieved impressive rhythmic synchronization, synthesizing gestures that are both semantically meaningful and faithful to a speaker's unique non‐verbal style remains an open challenge.
Adi Rosenthal, Tomer Koren, Nadav Shaked, Doron Friedman, Ariel Shamir   +4 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics and Exploratory Pharmacodynamics of Melanin‐Concentrating Hormone Receptor‐1 Antagonist RGH‐706 in Healthy and Overweight or Obese Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim This Phase 1 program evaluated the safety, tolerability, pharmacokinetics and exploratory pharmacodynamics of the novel melanin‐concentrating hormone receptor‐1 antagonist RGH‐706. Methods Study A was a first‐in‐man, randomized trial comprising a double‐blind, placebo‐controlled single‐ascending‐dose part (0.1–162.5 mg) and a two‐way ...
Thomas Brevig, Borbála Szepes, Zsófia Borbála Dombi, Gabriella Magyar, Zoltán Juhász, Margit Kapás, Éva Cseh, Zsuzsa Hegedűs, Tibor Farkas, Zsuzsanna Kiss, Balázs Szatmári   +10 more
wiley   +1 more source

Declining female participation: Mechanisms at play in the Viennese private annuity market, c. 1360–1450

The Economic History Review, EarlyView.
Abstract During the high and late Middle Ages, the European economy witnessed the emergence and substantial growth of capital markets, a phenomenon connected to urbanization and pestilence, both of which brought profound changes to the social, legal, and economic positions of women.
Anna Molnár
wiley   +1 more source

Corpses as Repositories of Information and Funerals as Information Centres: Why Natural Selection Favours the Bereaved

Ethology, EarlyView.
Corpses are repositories of information about the cause of death. The distress of the bereaved acts as an honest signal drawing conspecifics to the body, enabling them to learn quickly about the death, adapt their behaviour, and spread knowledge of threats across multiple social levels.
Jacob Dembitzer, Dror Ben‐Ami
wiley   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Human dissection and comparative anatomy: Archaeological evidence for nineteenth‐century anatomical practice at University College London

Journal of Anatomy, EarlyView.
Excavation at University College London revealed more than 8700 human skeletal fragments representing at least 38 individuals, alongside over 800 animal remains. Features consistent with dissection, specimen preparation and curation provide evidence for the use of human and animal material in nineteenth‐century anatomical education, offering rare ...
Wendy Birch, Tania Kausmally
wiley   +1 more source