Results 101 to 110 of about 537,118 (341)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Le tandem au service de l’intégration académique [PDF]

open access: yesSynergies Portugal, 2019
Le Centre de Langues de l’Université du Luxembourg propose chaque semestre des cours et ponctuellement des événements multilingues dans les trois langues officielles de l’université : le français, l’allemand et l’anglais.
Ève Lejot, Leslie Molostof
doaj  

Intradermal delivery of vaccines: potential benefits and current challenges

open access: yesBulletin of the World Health Organization, 2011
Delivery of vaccine antigens to the dermis and/or epidermis of human skin (i.e. intradermal delivery) might be more efficient than injection into the muscle or subcutaneous tissue, thereby reducing the volumes of antigen.
JK Hickling   +5 more
doaj   +1 more source

The Tandem Duplication Distance is NP-hard [PDF]

open access: yesarXiv, 2019
In computational biology, tandem duplication is an important biological phenomenon which can occur either at the genome or at the DNA level. A tandem duplication takes a copy of a genome segment and inserts it right after the segment - this can be represented as the string operation $AXB \Rightarrow AXXB$.
arxiv  

Tandem Wire Angioplasty [PDF]

open access: yesSeminars in Interventional Radiology, 2005
Stenotic lesions at vessel branch points are not uncommon. In arteries, sheer stress is thought to be atheroprotective, and disturbances in flow at ostia or bifurcations predispose to atherogenesis. When angioplasty of such stenotic lesions is necessary, “kissing balloon” or “tandem (buddy) wire” techniques are often employed.
openaire   +3 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Conception et évaluation d’un système innovant de production de foie gras : le cas de la substitution du maïs par du sorgho chez l’oie

open access: yesINRAE Productions Animales, 2013
Cet article présente le déroulement d’une démarche d’éco-conception pour proposer des innovations permettant de réduire les impacts environnementaux de la production de foie gras d’oie.
J. ARROYO   +7 more
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Potentials of InxGa1-xN photovoltaic tandems

open access: yesRevue des Énergies Renouvelables, 2011
During the past few years a great variety of multi-junction solar cells has been developed with the aim of a further increase in efficiency beyond the limits of single junction devices.
F. Bouzid, S. Ben Machiche
doaj  

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