Cancer, 2020 Omacetaxine mepesuccinate (OME) has antileukemic effects against acute myeloid leukemia (AML) carrying an internal tandem duplication of Fms‐like tyrosine kinase 3 (FLT3‐ITD).
Chunxiao Zhang +16 more
semanticscholar +1 more source
Haematologica, 2011 Background Fms-like tyrosine kinase-3 (FLT3) gene mutations are frequent in acute promyelocytic leukemia but their prognostic value is not well established.Design and Methods We evaluated FLT3-internal tandem duplication and FLT3-D835 mutations in ...
Eva Barragán +19 more
doaj +1 more source
Duplication Distance to the Root for Binary Sequences [PDF]
, 2016 We study the tandem duplication distance between binary sequences and their roots. In other words, the quantity of interest is the number of tandem duplication operations of the form x = abc → y = abbc, where x and y are sequences and a, b, and c are ...
Alon, Noga +3 more
core +3 more sources
Characterization and evolution of microRNA genes derived from repetitive elements and duplication events in plants. [PDF]
PLoS ONE, 2012 MicroRNAs (miRNAs) are a major class of small non-coding RNAs that act as negative regulators at the post-transcriptional level in animals and plants. In this study, all known miRNAs in four plant species (Arabidopsis thaliana, Populus trichocarpa, Oryza
Jie Sun +3 more
doaj +1 more source
Clusters of microRNAs emerge by new hairpins in existing transcripts [PDF]
, 2013 Genetic linkage may result in the expression of multiple products from a polycistronic transcript, under the control of a single promoter. In animals, protein-coding polycistronic transcripts are rare.
Alberts +66 more
core +2 more sources
Intron gain by tandem genomic duplication: a novel case in a potato gene encoding RNA-dependent RNA polymerase [PDF]
PeerJ, 2016 The origin and subsequent accumulation of spliceosomal introns are prominent events in the evolution of eukaryotic gene structure. However, the mechanisms underlying intron gain remain unclear because there are few proven cases of recently gained introns.
Ming-Yue Ma, Xin-Ran Lan, Deng-Ke Niu
doaj +2 more sources
The evolution of gene duplicates in angiosperms and the impact of protein-protein interactions and the mechanism of duplication [PDF]
, 2019 Gene duplicates, generated through either whole genome duplication (WGD) or small-scale duplication (SSD), are prominent in angiosperms and are believed to play an important role in adaptation and in generating evolutionary novelty.
Carretero-Paulet, Lorenzo +2 more
core +2 more sources
Evolution of Vertebrate Adam Genes; Duplication of Testicular Adams from Ancient Adam9/9-like Loci. [PDF]
PLoS ONE, 2015 Members of the disintegrin metalloproteinase (ADAM) family have important functions in regulating cell-cell and cell-matrix interactions as well as cell signaling.
Harinath Bahudhanapati +2 more
doaj +1 more source
Plants, 2023 Wheat (Triticum aestivum L.) is a staple food crop that provides 20% of total human calorie consumption. Gene duplication has been considered to play an important role in evolution by providing new genetic resources.
Licao Cui +5 more
doaj +1 more source
Host plant-dependent phenotypic reversion of Ralstonia solanacearum from non-pathogenic to pathogenic forms via alterations in the phcA gene [PDF]
, 2003 Ralstonia solanacearum is a plant pathogenic bacterium that undergoes a spontaneous phenotypic conversion (PC) from a wild-type pathogenic to a non-pathogenic form.
Arlat, Mathieu +6 more
core +1 more source