Results 51 to 60 of about 612,525 (237)

Genomic variations associated with attenuation in Mycobacterium avium subsp paratuberculosis vaccine strains [PDF]

, 2013
BACKGROUND: Mycobacterium avium subspecies paratuberculosis (MAP) whole cell vaccines have been widely used tools in the control of Johne's disease in animals despite being unable to provide complete protection. Current vaccine strains derive from stocks
Bull, TJ, Greene, M, Linedale, R, McKendrick, IJ, Sales, J, Schock, A, Sharp, JM, Stevenson, K   +7 more
core   +1 more source

Sorafenib plus intensive chemotherapy improves survival in patients with newly diagnosed, FLT3‐internal tandem duplication mutation–positive acute myeloid leukemia

Cancer, 2019
The addition of midostaurin to induction chemotherapy improves survival in younger patients with newly diagnosed, FLT3–mutated acute myeloid leukemia (AML). Sorafenib is a potent multikinase inhibitor with efficacy when given as monotherapy.
K. Sasaki, H. Kantarjian, T. Kadia, K. Patel, S. Loghavi, G. Garcia-Manero, E. Jabbour, C. Dinardo, N. Pemmaraju, N. Daver, I. A. Dalle, N. Short, M. Yilmaz, P. Bose, K. Naqvi, S. Pierce, Fevzi F. Yalniz, J. Cortes, F. Ravandi   +18 more
semanticscholar   +1 more source

Tandem duplications lead to novel expression patterns through exon shuffling in Drosophila yakuba.

PLoS Genetics, 2017
One common hypothesis to explain the impacts of tandem duplications is that whole gene duplications commonly produce additive changes in gene expression due to copy number changes.
Rebekah L Rogers, Ling Shao, Kevin R Thornton   +2 more
doaj   +1 more source

Massive Heat Shock Protein 70 Genes Expansion and Transcriptional Signatures Uncover Hard Clam Adaptations to Heat and Hypoxia

Frontiers in Marine Science, 2022
Heat shock protein 70 (HSP70) members participate in a wide range of housekeeping and stress-related activities in eukaryotic cells. In marine ecosystems, bivalves encounter abiotic stresses, including high temperatures and low dissolved oxygen.
Zhi Hu, Zhi Hu, Zhi Hu, Zhi Hu, Zhi Hu, Zhi Hu, Hao Song, Hao Song, Hao Song, Hao Song, Hao Song, Jie Feng, Jie Feng, Jie Feng, Jie Feng, Jie Feng, Cong Zhou, Cong Zhou, Cong Zhou, Cong Zhou, Cong Zhou, Cong Zhou, Mei-Jie Yang, Mei-Jie Yang, Mei-Jie Yang, Mei-Jie Yang, Mei-Jie Yang, Pu Shi, Pu Shi, Pu Shi, Pu Shi, Pu Shi, Pu Shi, Zheng-Lin Yu, Yong-Ren Li, Yong-Jun Guo, Hai-Zhou Li, Tao Zhang, Tao Zhang, Tao Zhang, Tao Zhang, Tao Zhang   +41 more
doaj   +1 more source

The capacity of some Pólya string models [PDF]

, 2016
We study random string-duplication systems, called Pólya string models, motivated by certain random mutation processes in the genome of living organisms.
Bruck, Jehoshua, Elishco, Ohad, Farnoud, Farzad, Schwartz, Moshe   +3 more
core   +1 more source

Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer

Nature Communications, 2019
Genome-wide analysis of genomic signatures might reveal novel mechanisms for gastric cancer (GC) tumorigenesis. Here, we analysis structural variations (SVs) and mutational signatures via whole-genome sequencing of 168 GCs.
Rui Xing, Yong Zhou, Jun Yu, Yingyan Yu, Y. Nie, Wen Luo, Chao Yang, T. Xiong, W. Wu, Zhongwu Li, Yang Bing, Shuye Lin, Yaping Zhang, Ying Hu, Lin Li, Lijuan Han, Chen Yang, Shaogang Huang, Suiping Huang, R. Zhou, Jing Li, Kaichun Wu, D. Fan, G. Tang, J. Dou, Zhenggang Zhu, J. Ji, X. Fang, Youyong Lu   +28 more
semanticscholar   +1 more source

The highly rearranged mitochondrial genomes of the crabs Maja crispata and Maja squinado (Majidae) and gene order evolution in Brachyura [PDF]

, 2017
We sequenced the mitochondrial genomes of the spider crabs Maja crispata and Maja squinado (Majidae, Brachyura). Both genomes contain the whole set of 37 genes characteristic of Bilaterian genomes, encoded on both \u3b1- and \u3b2-strands.
AD Miller, AE Smith, AH Sahyoun, AT Beckenbach, BQ Minh, C Hahn, C Moritz, DR Wolstenholme, DV Lavrov, E Negrisolo, F Jühling, F Kilpert, FJ Lin, G Shi, G Shi, G Sotelo, G Tan, G Tang, H Ma, H Shen, H Shimodaira, H Sun, I Marcadé, IM Fearnley, J Yang, JD Thompson, JL Boore, JL Boore, JL Boore, JL Boore, JM Sung, JM Sung, JS Ki, K Strimmer, K Tamura, LM Tsang, LS Quang, LT Nguyen, M Babbucci, M Bernt, M Bernt, M Bernt, M Dowton, M Hui, MH Tan, MH Tan, MM Yamauchi, N Lartillot, NT Perna, O Rota-Stabelli, P Cantatore, P Salvato, R Lanfear, R Raimond, RD Segawa, S Grave De, S Montelli, S Saito, SF Altschul, SJ Kim, SL Cameron, TA Rawlings, TM Lowe, X Wang, Y Xing, YK Ji, YQ Yu, Z Yang   +67 more
core   +1 more source

Hybridization capture-based next generation sequencing reliably detects FLT3 mutations and classifies FLT3-internal tandem duplication allelic ratio in acute myeloid leukemia: a comparative study to standard fragment analysis

Modern Pathology, 2019
FLT3-internal tandem duplication occurs in 20–30% of acute myeloid leukemia and confers an adverse prognosis with its allelic ratio being a key risk stratifier.
R. He, Daniel J. Devine, Z. Tu, M. Mai, Dong Chen, P. Nguyen, Jennifer L. Oliveira, J. Hoyer, K. Reichard, Paul L. Ollila, A. Al-Kali, A. Tefferi, K. Begna, M. Patnaik, H. Alkhateeb, D. Viswanatha   +15 more
semanticscholar   +1 more source

Structural characterization and duplication modes of pseudogenes in plants

Scientific Reports, 2021
We identified and characterized the pseudogene complements of five plant species: four dicots (Arabidopsis thaliana, Vitis vinifera, Populus trichocarpa and Phaseolus vulgaris) and one monocot (Oryza sativa).
Flavia Mascagni, Gabriele Usai, Andrea Cavallini, Andrea Porceddu   +3 more
doaj   +1 more source

Mechanism of tandem duplication formation in BRCA1 mutant cells

Nature, 2017
Small, approximately 10-kilobase microhomology-mediated tandem duplications are abundant in the genomes of BRCA1-linked but not BRCA2-linked breast cancer. Here we define the mechanism underlying this rearrangement signature.
Nicholas A. Willis, Richard L. Frock, F. Menghi, Erin E. Duffey, Arvind Panday, Virginia Camacho, P. Hasty, E. Liu, F. Alt, R. Scully   +9 more
semanticscholar   +1 more source