Results 21 to 30 of about 107,422 (289)

Covalently Linked Tandem Lesions in DNA [PDF]

Radiation Research, 2012
Reactive oxygen species (ROS) generate a type of DNA damage called tandem lesions, two adjacent nucleotides both modified. A subcategory of tandem lesions consists of adjacent nucleotides linked by a covalent bond. Covalently linked tandem lesions generate highly characteristic liquid chromotography-tandem mass spectrometry (LC-MS/MS) elution profiles.
Helen B, Patrzyc, Jean B, Dawidzik, Edwin E, Budzinski, Harold G, Freund, John H, Wilton, Harold C, Box   +5 more
openaire   +2 more sources

Efficacy of emergent internal carotid artery stenting after intracranial thrombectomy for acute internal carotid artery stenosis related tandem lesions

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
Objective To investigate the efficacy and safety of emergent carotid artery stenting (CAS) after intracranial artery mechanical thrombectomy for acute internal carotid artery (ICA) stenosis related tandem lesions.
XU Na, YI Ting⁃yu, WANG Ze⁃tuo, WU Yan⁃min , LIN Ding⁃lai , CHEN Wen⁃huo   +5 more
doaj   +1 more source

Tandem Lesions in Anterior Circulation Stroke [PDF]

Stroke, 2021
Background and Purpose: Tandem lesions in the anterior circulation account for up to 30% of all large vessel occlusion strokes. The optimal periprocedural approach in these lesions is still a matter of debate. Methods: Data from the ...
Katharina Feil, Moriz Herzberg, Franziska Dorn, Steffen Tiedt, Clemens Küpper, Dennis C. Thunstedt, Panagiotis Papanagiotou, Lukas Meyer, Andreas Kastrup, Konstantinos Dimitriadis, Thomas Liebig, Marianne Dieterich, Lars Kellert, Tobias Boeckh-Behrens, Silke Wunderlich, Alexander Ludolph, Karl-Heinz Henn, Arno Reich, Anastasios Mpotsaris, Martin Wiesmann, Ulrike Ernemann, Sven Poli, Christian H. Nolte, Eberhard Siebert, Sarah Zweynert, Georg Bohner, Laszlo Solymosi, Gabor Petzold, Waltraud Pfeilschifter, Fee Keil, Joachim Röther, Bernd Eckert, Jörg Berrouschot, Albrecht Bormann, Anna Alegiani, Jens Fiehler, Christian Gerloff, Götz Thomalla, Sven Thonke, Christopher Bangard, Christoffer Kraemer, Martin Dichgans, Marios Psychogios, Jan Liman, Martina Petersen, Florian Stögbauer, Peter Kraft, Mirko Pham, Michael Braun, Gerhard F. Hamann, Christian Roth, Klaus Gröschel, Timo Uphaus, Volker Limmroth   +53 more
openaire   +3 more sources

Diagnosis and management of tandem occlusion in acute ischemic stroke

European Journal of Radiology Open, 2023
Approximately 20–30% of patients with acute ischemic stroke, caused by large intracranial vessel occlusion, have a tandem lesion, defined as simultaneous presence of high-grade stenosis or occlusion of the cervical internal carotid artery and ...
Antonio Di Donna, Gianluca Muto, Flavio Giordano, Massimo Muto, Gianluigi Guarnieri, Giovanna Servillo, Antonio De Mase, Emanuele Spina, Giuseppe Leone   +8 more
doaj   +1 more source

Mechanical Thrombectomy for Tandem Occlusions of the Internal Carotid Artery—Results of a Conservative Approach for the Extracranial Lesion

Frontiers in Neurology, 2018
Background: Mechanical thrombectomy (MT) is of clinical benefit for patients with extracranial-intracranial tandem lesions of anterior circulation. However, the optimal approach to the cervical lesion of the internal carotid artery (ICA) during MT has ...
Alexandre Blassiau, Matthias Gawlitza, Pierre-François Manceau, Serge Bakchine, Isabelle Serre, Sébastien Soize, Laurent Pierot   +6 more
doaj   +1 more source

Balloon‐Expandable Stenting as a Bridging Therapy in Patients With Acute Stroke and Tandem Occlusions

Stroke: Vascular and Interventional Neurology, 2023
Background Stenting extracranial internal carotid artery (ICA) lesions in acute ischemic stroke with tandem lesions is technically challenging. Its safety is highly debated because of the requirement of dual‐antiplatelet therapy.
Noelia Rodríguez‐Villatoro, David Rodríguez‐Luna, Marian Muchada, Olalla Pancorbo, Matías Deck, Prudencio Lozano, Sandra Boned, Álvaro García‐Tornel, Marta Olivé, Jesús Juega, Jorge Pagola, Marta Rubiera, David Hernández, Carlos Molina, Carlos Piñana, Isabel Rodriguez, Marta De Dios, Jose Luis Cuevas, Manuel Requena, Laura Ludovica Gramegna, Marc Ribó, Alejandro Tomasello   +21 more
doaj   +1 more source

The Influence of (5′R)- and (5′S)-5′,8-Cyclo-2′-Deoxyadenosine on UDG and hAPE1 Activity. Tandem Lesions are the Base Excision Repair System’s Nightmare

Cells, 2019
DNA lesions are formed continuously in each living cell as a result of environmental factors, ionisation radiation, metabolic processes, etc. Most lesions are removed from the genome by the base excision repair system (BER).
Bolesław T. Karwowski
doaj   +1 more source

Syntheses and characterizations of the in vivo replicative bypass and mutagenic properties of the minor-groove O2-alkylthymidine lesions. [PDF]

, 2014
Endogenous metabolism, environmental exposure, and treatment with some chemotherapeutic agents can all give rise to DNA alkylation, which can occur on the phosphate backbone as well as the ring nitrogen or exocyclic nitrogen and oxygen atoms of ...
Cai, Qian, Wang, Pengcheng, Wang, Yinsheng, Zhai, Qianqian   +3 more
core   +1 more source

Ostial common carotid artery occlusion and balloon-mounted stenting: Implication of embolic protection device in tandem lesion

Radiology Case Reports, 2021
Ostial common carotid artery (CCA) stenosis is rare, compared to extracranial internal carotid artery bifurcation lesions. In cases of a tandem lesion, the proximal lesion usually involves the extracranial internal carotid artery, and the ostial CCA is ...
Takashi Mizowaki, MD, PhD, Atsushi Fujita, MD, PhD, Jun Imura, MD, Masahiro Nakahara, MD, Hirotomo Tanaka, MD, PhD, Yoshiyuki Takaishi, MD, PhD, Takeshi Kondoh, MD, PhD   +6 more
doaj   +1 more source

Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations. [PDF]

, 2019
Fluoroquinolones represent the pillar of multidrug-resistant tuberculosis (MDR-TB) treatment, with moxifloxacin, levofloxacin, or gatifloxacin being prescribed to MDR-TB patients.
Alvarez-Cabrera, Nadine, Blanc, Landry, Dartois, Véronique, Dias-Freedman, Isabela, Dietzold, Jillian, Ho Liang, Hsin-Pin, Kaya, Firat, Kirschner, Denise, Linderman, Jennifer, Mina, Marizel, O'Brien, Paul, Pienaar, Elsje, Prideaux, Brendan, Salgame, Padmini, Sarathy, Jansy, Savic, Radojka M, Zimmerman, Matthew   +16 more
core   +2 more sources