Results 21 to 30 of about 887,704 (273)

When UDG and hAPE1 Meet Cyclopurines. How (5′R) and (5′S) 5′,8-Cyclo-2′-deoxyadenosine and 5′,8-Cyclo-2′-deoxyguanosine Affect UDG and hAPE1 Activity?

Molecules, 2021
Ionizing radiation is a factor that seriously damages cellular mechanisms/macromolecules, e.g., by inducing damage in the human genome, such as 5′,8-cyclo-2′-deoxypurines (cdPus).
Michał Szewczuk, Karolina Boguszewska, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski   +3 more
doaj   +1 more source

A Case Series and Literature Review of Vertebral Artery Stump Syndrome

Frontiers in Neurology, 2022
PurposeStump syndrome refers to cerebral ischaemic symptoms caused by an embolus from a previously occluded ipsilateral artery that occludes a down-stream artery.
Wenbin Zhang, Shouchun Wang, Chao Li, Zhongxiu Wang, Feixue Yue, Jie Zhou, Kangjia Song, Chao Wang, Yujiao Wang, Mingchao Shi   +9 more
doaj   +1 more source

Revisiting Antiplatelet Therapy in Acute Carotid Tandem Lesions. [PDF]

J Clin Med
Background/Objectives: Acute carotid tandem lesions (TLs), defined by concurrent cervical internal carotid artery (ICA) stenosis or occlusion and intracranial large vessel occlusion, occur in 10–20% of patients undergoing mechanical thrombectomy (MT) for acute ischemic stroke (AIS). Optimal periprocedural antiplatelet management during emergent carotid
Zupan M, Straus L, Kermer P, Papanagiotou P, Frol S.   +4 more
europepmc   +3 more sources

Covalently Linked Tandem Lesions in DNA [PDF]

Radiation Research, 2012
Reactive oxygen species (ROS) generate a type of DNA damage called tandem lesions, two adjacent nucleotides both modified. A subcategory of tandem lesions consists of adjacent nucleotides linked by a covalent bond. Covalently linked tandem lesions generate highly characteristic liquid chromotography-tandem mass spectrometry (LC-MS/MS) elution profiles.
Helen B, Patrzyc, Jean B, Dawidzik, Edwin E, Budzinski, Harold G, Freund, John H, Wilton, Harold C, Box   +5 more
openaire   +2 more sources

Endovascular treatment of tandem lesions in a novel cadaveric stroke model. [PDF]

EuroIntervention
Grunwald IQ, Tekieli L, Podlasek A, Donald-Simpson H, Clark S, Voutsas C, Pillai S, Houston G, Knapik M, White L, Barr P, Melzer A, Musialek P.   +12 more
europepmc   +5 more sources

Efficacy of emergent internal carotid artery stenting after intracranial thrombectomy for acute internal carotid artery stenosis related tandem lesions

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
Objective To investigate the efficacy and safety of emergent carotid artery stenting (CAS) after intracranial artery mechanical thrombectomy for acute internal carotid artery (ICA) stenosis related tandem lesions.
XU Na, YI Ting⁃yu, WANG Ze⁃tuo, WU Yan⁃min , LIN Ding⁃lai , CHEN Wen⁃huo   +5 more
doaj   +1 more source

Tandem Lesions in Anterior Circulation Stroke [PDF]

Stroke, 2021
Background and Purpose: Tandem lesions in the anterior circulation account for up to 30% of all large vessel occlusion strokes. The optimal periprocedural approach in these lesions is still a matter of debate. Methods: Data from the ...
Katharina Feil, Moriz Herzberg, Franziska Dorn, Steffen Tiedt, Clemens Küpper, Dennis C. Thunstedt, Panagiotis Papanagiotou, Lukas Meyer, Andreas Kastrup, Konstantinos Dimitriadis, Thomas Liebig, Marianne Dieterich, Lars Kellert, Tobias Boeckh-Behrens, Silke Wunderlich, Alexander Ludolph, Karl-Heinz Henn, Arno Reich, Anastasios Mpotsaris, Martin Wiesmann, Ulrike Ernemann, Sven Poli, Christian H. Nolte, Eberhard Siebert, Sarah Zweynert, Georg Bohner, Laszlo Solymosi, Gabor Petzold, Waltraud Pfeilschifter, Fee Keil, Joachim Röther, Bernd Eckert, Jörg Berrouschot, Albrecht Bormann, Anna Alegiani, Jens Fiehler, Christian Gerloff, Götz Thomalla, Sven Thonke, Christopher Bangard, Christoffer Kraemer, Martin Dichgans, Marios Psychogios, Jan Liman, Martina Petersen, Florian Stögbauer, Peter Kraft, Mirko Pham, Michael Braun, Gerhard F. Hamann, Christian Roth, Klaus Gröschel, Timo Uphaus, Volker Limmroth   +53 more
openaire   +3 more sources

Mechanical Thrombectomy for Tandem Occlusions of the Internal Carotid Artery—Results of a Conservative Approach for the Extracranial Lesion

Frontiers in Neurology, 2018
Background: Mechanical thrombectomy (MT) is of clinical benefit for patients with extracranial-intracranial tandem lesions of anterior circulation. However, the optimal approach to the cervical lesion of the internal carotid artery (ICA) during MT has ...
Alexandre Blassiau, Matthias Gawlitza, Pierre-François Manceau, Serge Bakchine, Isabelle Serre, Sébastien Soize, Laurent Pierot   +6 more
doaj   +1 more source

Diagnosis and management of tandem occlusion in acute ischemic stroke

European Journal of Radiology Open, 2023
Approximately 20–30% of patients with acute ischemic stroke, caused by large intracranial vessel occlusion, have a tandem lesion, defined as simultaneous presence of high-grade stenosis or occlusion of the cervical internal carotid artery and ...
Antonio Di Donna, Gianluca Muto, Flavio Giordano, Massimo Muto, Gianluigi Guarnieri, Giovanna Servillo, Antonio De Mase, Emanuele Spina, Giuseppe Leone   +8 more
doaj   +1 more source

The Influence of (5′R)- and (5′S)-5′,8-Cyclo-2′-Deoxyadenosine on UDG and hAPE1 Activity. Tandem Lesions are the Base Excision Repair System’s Nightmare

Cells, 2019
DNA lesions are formed continuously in each living cell as a result of environmental factors, ionisation radiation, metabolic processes, etc. Most lesions are removed from the genome by the base excision repair system (BER).
Bolesław T. Karwowski
doaj   +1 more source