Results 31 to 40 of about 55,349 (160)

When UDG and hAPE1 Meet Cyclopurines. How (5′R) and (5′S) 5′,8-Cyclo-2′-deoxyadenosine and 5′,8-Cyclo-2′-deoxyguanosine Affect UDG and hAPE1 Activity?

Molecules, 2021
Ionizing radiation is a factor that seriously damages cellular mechanisms/macromolecules, e.g., by inducing damage in the human genome, such as 5′,8-cyclo-2′-deoxypurines (cdPus).
Michał Szewczuk, Karolina Boguszewska, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski   +3 more
doaj   +1 more source

A Case Series and Literature Review of Vertebral Artery Stump Syndrome

Frontiers in Neurology, 2022
PurposeStump syndrome refers to cerebral ischaemic symptoms caused by an embolus from a previously occluded ipsilateral artery that occludes a down-stream artery.
Wenbin Zhang, Shouchun Wang, Chao Li, Zhongxiu Wang, Feixue Yue, Jie Zhou, Kangjia Song, Chao Wang, Yujiao Wang, Mingchao Shi   +9 more
doaj   +1 more source

Covalently Linked Tandem Lesions in DNA [PDF]

Radiation Research, 2012
Reactive oxygen species (ROS) generate a type of DNA damage called tandem lesions, two adjacent nucleotides both modified. A subcategory of tandem lesions consists of adjacent nucleotides linked by a covalent bond. Covalently linked tandem lesions generate highly characteristic liquid chromotography-tandem mass spectrometry (LC-MS/MS) elution profiles.
Helen B, Patrzyc, Jean B, Dawidzik, Edwin E, Budzinski, Harold G, Freund, John H, Wilton, Harold C, Box   +5 more
openaire   +2 more sources

Radiation-induced formation of tandem lesions: mechanistic aspect

, 2015
International audienceDuring the last three decades considerable efforts have been made to determine the nature and quantify the amount of lesions produced in double stranded (ds)DNA exposed to oxidative stress.
Ravanat, Jean-Luc
core   +3 more sources

The Challenge of an Acute Antithrombotic Regimen for Treatment of Tandem Lesions Stroke. [PDF]

AJNR Am J Neuroradiol, 2021
In the treatment of tandem stroke, several studies have shown the efficacy and safety of endovascular treatment. However, there are many unanswered questions regarding this treatment strategy including technical aspects as well as peri- and postprocedural antithrombotic management.
Papanagiotou P, Gory B.
europepmc   +4 more sources

Efficacy of emergent internal carotid artery stenting after intracranial thrombectomy for acute internal carotid artery stenosis related tandem lesions

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
Objective To investigate the efficacy and safety of emergent carotid artery stenting (CAS) after intracranial artery mechanical thrombectomy for acute internal carotid artery (ICA) stenosis related tandem lesions.
XU Na, YI Ting⁃yu, WANG Ze⁃tuo, WU Yan⁃min , LIN Ding⁃lai , CHEN Wen⁃huo   +5 more
doaj   +1 more source

Revisiting Antiplatelet Therapy in Acute Carotid Tandem Lesions. [PDF]

J Clin Med
Background/Objectives: Acute carotid tandem lesions (TLs), defined by concurrent cervical internal carotid artery (ICA) stenosis or occlusion and intracranial large vessel occlusion, occur in 10–20% of patients undergoing mechanical thrombectomy (MT) for acute ischemic stroke (AIS). Optimal periprocedural antiplatelet management during emergent carotid
Zupan M, Straus L, Kermer P, Papanagiotou P, Frol S.   +4 more
europepmc   +2 more sources

Endovascular treatment of tandem lesions in a novel cadaveric stroke model. [PDF]

EuroIntervention
Grunwald IQ, Tekieli L, Podlasek A, Donald-Simpson H, Clark S, Voutsas C, Pillai S, Houston G, Knapik M, White L, Barr P, Melzer A, Musialek P.   +12 more
europepmc   +5 more sources

Bow-Hunter Syndrome Due to Tandem Lesions; A Case Report. [PDF]

Asian J Neurosurg
AbstractBow–Hunter syndrome (BHS) includes a form of stroke caused by dynamic factors affecting the extracranial vertebral artery (VA), such as rotation-induced flow disturbance at the atlantoaxial level. BHS is a rare condition that can result from a variety of factors, including abnormal bone compression and vertebral instability.
Yokoya S, Nakauchi J, Takezawa H.
europepmc   +3 more sources

Mechanical Thrombectomy for Tandem Occlusions of the Internal Carotid Artery—Results of a Conservative Approach for the Extracranial Lesion

Frontiers in Neurology, 2018
Background: Mechanical thrombectomy (MT) is of clinical benefit for patients with extracranial-intracranial tandem lesions of anterior circulation. However, the optimal approach to the cervical lesion of the internal carotid artery (ICA) during MT has ...
Alexandre Blassiau, Matthias Gawlitza, Pierre-François Manceau, Serge Bakchine, Isabelle Serre, Sébastien Soize, Laurent Pierot   +6 more
doaj   +1 more source