Results 171 to 180 of about 418,182 (306)

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Phytochemical Analysis of Veratrum Alkaloids in Medicinal Veratrum Globules Using High-Performance Liquid Chromatography Coupled With Tandem Mass Spectrometry. [PDF]

Biomed Chromatogr
Siegle J, Pietsch J.
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Comparability of Liquid Chromatography Tandem Mass Spectrometry Analysis of Dissolved Organic Matter across Laboratories. [PDF]

Environ Sci Technol
Kalinski JC, Ruiz Brandão da Costa B, Schramm T, Buckett LR, Carlson LT, Coffey NR, Damiani T, Dechent E, Abiead YE, Heuckeroth S, Jennings EK, Kaesler J, Stock NL, Orme AM, Torres RR, Trojahn S, Whelton HL, Yan Y, Aron AT, Boiteau RM, Bull ID, Dorrestein PC, Dang DH, Evershed RP, Gledhill M, Gleixner G, Haas AF, Hansen M, Harder T, Hopmans EC, Ingalls AE, Karst U, Kew W, Kido Soule M, Koch BP, Kujawinski EB, Lechtenfeld OJ, Longnecker K, Pluskal T, Pohnert G, Redman ZC, Rivas-Ubach A, Schmitt-Kopplin P, Singer G, Tebben J, Tomco PL, Ward ND, Aluwihare LI, Simon C, Hawkes J, Petras D.   +50 more
europepmc   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Analysis of polychlorinated alkanes in food by liquid chromatography-tandem mass spectrometry. [PDF]

Anal Bioanal Chem
Perkons I, Lazdina L, Zacs D.
europepmc   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Revealing deamidation and isoaspartate formation during peptide analysis, purification and storage by tandem mass spectrometry. [PDF]

RSC Med Chem
Erckes V, Rendueles LC, Misiek A, Steuer C.   +3 more
europepmc   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

Instrumental Dispersion Evaluation on Supercritical Fluid Chromatography-Medium Vacuum Chemical Ionization Tandem Mass Spectrometry. [PDF]

Mass Spectrom (Tokyo)
Hondo T, Miyake Y, Toyoda M.
europepmc   +1 more source