Results 231 to 240 of about 955,547 (405)

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Assessment of false discovery rate control in tandem mass spectrometry analysis using entrapment. [PDF]

Nat Methods
Wen B, Freestone J, Riffle M, MacCoss MJ, Noble WS, Keich U.   +5 more
europepmc   +1 more source

Stability of 11-Nor-Δ9-carboxy-tetrahydrocannabinol Glucuronide in Plasma and Urine Assessed by Liquid Chromatography-Tandem Mass Spectrometry [PDF]

, 2002
Gisela Skopp, Lucia Pötsch
openalex   +1 more source

Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Advanced Science, EarlyView.
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang, Yongxiang Liu, Huanling Zhang, Huan Jin, Feifei Xu, Xiaojuan Wang, Chunyuan Xie, Hui Guo, Tiantian Wang, Yanxun Lin, Qi Zhao, Penghui Zhou, Jing Tan, Jin‐Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +19 more
wiley   +1 more source

Tandem mass spectrometry of homologous 3-hydroxyfurazan and nitrile amino acids: Analysis of cooperative interactions and fragmentation processes [PDF]

Boschi, Donatella, Lolli, Marco L
core   +1 more source

Effect of trimethoprim on Calliphora stygia (Diptera: Calliphoridae) larvae growth and detection via liquid chromatography-tandem mass spectrometry. [PDF]

J Med Entomol
McIntyre DB, Pantha K, Barton PS, Long BM.   +3 more
europepmc   +1 more source

Determination of Oligosaccharides in Pompe Disease by Electrospray Ionization Tandem Mass Spectrometry [PDF]

, 2002
Tina Rozaklis, Steven L. Ramsay, Phillip D. Whitfield, Enzo Ranieri, John J. Hopwood, Peter J. Meikle   +5 more
openalex   +1 more source

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

Advanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen   +13 more
wiley   +1 more source

A Label-Free Liquid Chromatography-Tandem Mass Spectrometry Method for the Quantitative Analysis of Exosome Pharmacokinetics In Vivo. [PDF]

Pharmaceutics
Li B, Yu F.
europepmc   +1 more source

Analysis of Carnitine Biosynthesis Metabolites in Urine by HPLC–Electrospray Tandem Mass Spectrometry [PDF]

, 2002
Frédéric M. Vaz, Béla Melegh, Judit Bene, D Cuebas, Douglas A. Gage, Albert H. Bootsma, P. Vreken, Albert H. Gennip, L.L. Bieber, Ronald J. A. Wanders   +9 more
openalex   +1 more source