Results 241 to 250 of about 418,182 (306)

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

Comparison of the determination of cortisol in canine saliva by chemiluminescence immunoassay and liquid chromatography-tandem mass spectrometry. [PDF]

J Vet Diagn Invest
Schroers M, Zablotski Y, Meyer-Lindenberg A.   +2 more
europepmc   +1 more source

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

Tandem mass spectrometry fragmentation patterns of sulfo-SDA cross-linked peptides. [PDF]

Eur J Mass Spectrom (Chichester)
Powell T, Ebner M, Creese A.
europepmc   +1 more source

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, EarlyView.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Rapid and Sensitive Quantification of Nano- and Microplastics in Water, Sediment, and Biological Tissue by Pyrolysis-Gas Chromatography Tandem Mass Spectrometry with Dynamic Reaction Monitoring. [PDF]

Anal Chem
Gahn MB, Wharton M, Mortuza A, Hala D, Marshall CD, Kaiser K.   +5 more
europepmc   +1 more source

2D Metal‐Organic Frameworks for High‐Performance Solid‐State Electrolytes: A Comprehensive Review

Advanced Science, EarlyView.
In this review, we elucidate the intrinsic advantages, synthetic methodologies, structural characteristics, ion‐transport mechanisms and performance optimization strategies while highlighting representative material systems and applications of 2D MOFs for electrolyte applications.
Changchun Ai, Yuan Tian, Yilei Shu, Peng Hang, Wentao Li, Yiling Yao, Huijuan Guo, Qun Yi, Hongmei Dai   +8 more
wiley   +1 more source

Newborn screening for inherited metabolic disorders in central China: a retrospective study of 153,956 infants using non-derivatized tandem mass spectrometry. [PDF]

Sci Rep
Han D, Tao Y, Li J, Wang L, Song W, Li X.   +5 more
europepmc   +1 more source

Analytical development and application of a targeted liquid chromatography-tandem mass spectrometry assay for chimeric aducanumab. [PDF]

MAbs
Doud EH, Hansen K, Haynes KA, Eldridge K, Arrivalagan J, Charbe N, Da Silva L, Quinney SK, Mosley AL, Rizzo SJS, Territo PR.   +10 more
europepmc   +1 more source

Supercritical CO₂ Extraction and Tandem Mass Spectrometry of the Medicinal Plant Sagan Dalya (<i>Rhododendron adamsii</i>). [PDF]

Pharmaceuticals (Basel)
Razgonova MP, Zakharenko AM, Golokhvast KS.   +2 more
europepmc   +1 more source