Results 61 to 70 of about 286,551 (289)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Tandem Mass Spectrometry across Platforms

Analytical Chemistry
PubChem serves as a comprehensive repository, housing over 100 million unique chemical structures representing the breadth of our chemical knowledge across numerous fields including metabolism, pharmaceuticals, toxicology, cosmetics, agriculture, and many more. Rapid identification of these small molecules increasingly relies on electrospray ionization
Corey Hoang, Winnie Uritboonthai, Linh Hoang, Elizabeth M. Billings, Aries Aisporna, Farshad A. Nia, Rico J. E. Derks, James R. Williamson, Martin Giera, Gary Siuzdak   +9 more
openaire   +3 more sources

Tandem mass spectrometry of deprotonated iodothyronines [PDF]

Rapid Communications in Mass Spectrometry, 2005
AbstractIn order to assist with the development of more selective and sensitive methods for thyroid hormone analysis the [M–H]− anions of the iodothyronines T4, T3, rT3, (3,5)‐T2 and the non‐iodinated thyronine (T0) have been generated by negative ion electrospray mass spectrometry. Tandem mass spectra of these ions were recorded on a triple‐quadrupole
Couldwell, A. M., Thomas, M. C., Mitchell, Todd, Hulbert, A., Blanksby, Stephen J.   +4 more
openaire   +4 more sources

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Mapping Post‐Transcriptional Modifications onto  Transfer Ribonucleic Acid Sequences by Liquid  Chromatography Tandem Mass Spectrometry

Biomolecules, 2017
Liquid chromatography, coupled with tandem mass spectrometry, has become one of the most popular methods for the analysis of post‐transcriptionally modified transfer ribonucleic acids (tRNAs).
Robert L. Ross, Xiaoyu Cao, Patrick A. Limbach   +2 more
doaj   +1 more source

A novel framework to quantify uncertainty in peptide-tandem mass spectrum matches with application to nanobody peptide identification [PDF]

arXiv, 2021
Nanobodies are small antibody fragments derived from camelids that selectively bind to antigens. These proteins have marked physicochemical properties that support advanced therapeutics, including treatments for SARS-CoV-2. To realize their potential, bottom-up proteomics via liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been proposed ...
arxiv  

Unleashing the Power of Multiomics: Unraveling the Molecular Landscape of Peripheral Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Peripheral neuropathies (PNs) affect over 20 million individuals in the United States, manifesting as a wide range of sensory, motor, and autonomic nerve symptoms. While various conditions such as diabetes, metabolic disorders, trauma, autoimmune disease, and chemotherapy‐induced neurotoxicity have been linked to PN, approximately one‐third of
Julie Choi, Zitian Tang, Wendy Dong, Jenna Ulibarri, Elvisa Mehinovic, Simone Thomas, Ahmet Höke, Sheng Chih Jin   +7 more
wiley   +1 more source

Analysis of posttranslational modifications of proteins by tandem mass spectrometry Mass Spectrometry For Proteomics Analysis

BioTechniques, 2006
Protein activity and turnover is tightly and dynamically regulated in living cells. Whereas the three-dimensional protein structure is predominantly determined by the amino acid sequence, posttranslational modification (PTM) of proteins modulates their ...
Martin R. Larsen, Morten B. Trelle, Tine E. Thingholm, Ole N. Jensen   +3 more
doaj   +1 more source

Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry

Communications Chemistry, 2021
Mass spectrometry can be used for structural determination of N-glycans, but commonly requires prior derivatisation or comparison to a library of standards.
Chia Yen Liew, Chu-Chun Yen, Jien-Lian Chen, Shang-Ting Tsai, Sujeet Pawar, Chung-Yi Wu, Chi-Kung Ni   +6 more
doaj   +1 more source