Results 61 to 70 of about 3,585,745 (304)

Concurrent identification of 11 major primary active compounds in Huangqin Qingfei Decoction by liquid chromatography tandem mass spectrometry via liquid chromatography tandem mass spectrometry

Pakistan Journal of Pharmaceutical Sciences, 2020
Huangqin Qinfei Decoction (HQD) is a traditional Chinese medicine that is administered for acute pneumonia, bronchial inflammation, acute bronchitis and acute lung infection.
Yi-Fan Zhang, Ye Lu, Juan Xiao, Ye Chen, Xin-Hong Wang   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Sequencing and Identification of Endogenous Neuropeptides with Matrix-Enhanced Secondary Ion Mass Spectrometry Tandem Mass Spectrometry

, 2017
Matrix-enhanced secondary ion mass spectrometry (ME-SIMS) has overcome one of the biggest disadvantages of SIMS analysis by providing the ability to detect intact biomolecules at high spatial resolution. By increasing ionization efficiency and minimizing
Nina Ogrinc Potočnik, Heeren, Ron M. A., Gregory L. Fisher, Arnoud Prop, Fisher, Gregory L., Prop, Arnoud, Potocnik, Nina Ogrinc, Ron M. A. Heeren   +7 more
core   +1 more source

Peak intensity prediction in MALDI-TOF mass spectrometry: A machine learning study to support quantitative proteomics [PDF]

, 2008
Timm W, Scherbart A, Boecker S, Kohlbacher O, Nattkemper TW. Peak intensity prediction in MALDI-TOF mass spectrometry: A machine learning study to support quantitative proteomics. BMC Bioinformatics.
Nattkemper, Tim Wilhelm ; https://orcid.org/, Nattkemper Tim W, Wiebke A Timm, Boecker, Sebastian, Kohlbacher, Oliver, Scherbart Alexandra, Kohlbacher Oliver, Sebastian Bocker, Tim W Nattkemper, Alexandra Scherbart, Scherbart, Alexandra, Timm, Wiebke, Timm Wiebke, Oliver Kohlbacher, Böcker Sebastian   +14 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liquid Chromatography Tandem Mass Spectrometry Quantification of ¹³C-Labeling in Sugars

Metabolites, 2020
Subcellular compartmentation has been challenging in plant 13C-metabolic flux analysis. Indeed, plant cells are highly compartmented: they contain vacuoles and plastids in addition to the regular organelles found in other eukaryotes.
Jean-Christophe Cocuron, Zacchary Ross, Ana P. Alonso   +2 more
doaj   +1 more source

Mass Spectrometry and Tandem Mass Spectrometry: An Overview

, 2014
In this chapter, a brief overview of fundamentals in mass spectrometry and of its applications in homeland security, forensic sciences and explosive detection, are presented.
openaire   +3 more sources

The Composition of Poly(Ethylene Terephthalate) (PET) Surface Precipitates Determined at High Resolving Power by Tandem Mass Spectrometry Imaging [PDF]

, 2017
We present the first demonstration of a general method for the chemical characterization of small surface features at high magnification via simultaneous collection of mass spectrometry (MS) imaging and tandem MS imaging data.
Scott R. Bryan, Heeren, Ron M. A., Gregory L. Fisher, John S. Hammond, Bryan, Scott R., Larson, Paul E., Fisher, Gregory L., Hammond, John S., Paul E. Larson, Ron M. A. Heeren   +9 more
core   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Absorption mode FTICR mass spectrometry imaging [PDF]

, 2013
Fourier transform ion cyclotron resonance mass spectrometry offers the highest mass resolving power for molecular imaging experiments. This high mass resolving power ensures that closely spaced peaks at the same nominal mass are resolved for proper image
Konijnenburg, Marco, Heeren, Ron M. A., O’Connor, Peter B., Heeren, R.M.A., Smith, Donald Francis, Kilgour, David P. A., Kilgour, D.P.A., Konijnenburg, M., Smith, D.F., Sub Biomol.Mass Spectrometry & Proteom., O'Connor, P.B., Biomolecular Mass Spectrometry and Proteomics   +11 more
core   +1 more source