Results 71 to 80 of about 286,551 (289)

GA-Novo: De Novo Peptide Sequencing via Tandem Mass Spectrometry using Genetic Algorithm [PDF]

arXiv, 2019
Proteomics is the large-scale analysis of the proteins. The common method for identifying proteins and characterising their amino acid sequences is to digest the proteins into peptides, analyse the peptides using mass spectrometry and assign the resulting tandem mass spectra (MS/MS) to peptides using database search tools.
arxiv  

Pharmacokinetics, Efficacy, and Safety of Upadacitinib in Pediatric Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis: An Interim Analysis of an Open‐Label, Phase 1 Trial

Arthritis Care &Research, EarlyView.
Objective This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods In an open‐label, phase 1 study (SELECT‐YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight–based ...
Hermine I. Brunner, Anna Shmagel, Gerd Horneff, Ivan Foeldvari, Jordi Antón, Athimalaipet V. Ramanan, Yuli Qian, Kristina Unnebrink, Shuai Hao, Heidi S. Camp, Nasser Khan, Wei Liu, Mohamed‐Eslam F. Mohamed   +12 more
wiley   +1 more source

Two-dimensional mass spectrometry: new perspectives for tandem mass spectrometry [PDF]

European Biophysics Journal, 2019
Fourier transform ion cyclotron resonance mass analysers (FT-ICR MS) can offer the highest resolutions and mass accuracies in mass spectrometry. Mass spectra acquired in an FT-ICR MS can yield accurate elemental compositions of all compounds in a complex sample. Fragmentation caused by ion-neutral, ion-electron, or ion-photon interactions leads to more
Maria A. van Agthoven, Yuko P. Y. Lam, Peter B. O’Connor, Christian Rolando, Marc-André Delsuc   +4 more
openaire   +7 more sources

Determination of Diphenylamine in Gunshot Residue by HPLC-MS/MS

Journal of Forensic Science and Medicine, 2016
A high performance liquid chromatography tandem mass spectrometry/mass spectrometry (HPLC-MS/MS) protocol was developed for the determination of diphenylamine (DPA).
Hongcheng Mei, Yangke Quan, Wenhao Wang, Hong Zhou, Zhanfang Liu, Huixia Shi, Peng Wang   +6 more
doaj   +1 more source

Spider Silk: Rapid, Bottom‐Up Self‐Assembly of MaSp1 into Hierarchically Structured Fibers Through Biomimetic Processing

Advanced Functional Materials, EarlyView.
Spider dragline silk has extraordinary mechanical properties due to the underlying hierarchical organization of the fiber across multiple length scales. A biomimetic platform for MaSp1 is developed, the main protein component of dragline silk, and thereby elucidates the parameters governing its rapid self‐assembly from soluble protein into complex ...
Ali D. Malay, Nur Alia Oktaviani, Jianming Chen, Keiji Numata   +3 more
wiley   +1 more source

Seminolipid and its precursor/degradative product, galactosylalkylacylglycerol, in the testis of saposin A- and prosaposin-deficient mice

Journal of Lipid Research, 2003
Sphingolipid activator proteins (saposins A, B, C, and D) are derived from a common precursor protein (prosaposin) and specifically activate in vivo degradation of glycolipids with short carbohydrate chains.
Keiko Tadano-Aritomi, Junko Matsuda, Hirokazu Fujimoto, Kunihiko Suzuki, Ineo Ishizuka   +4 more
doaj  

Sucrose gradient chromatin enrichment for quantitative proteomics analysis in budding yeast

STAR Protocols, 2021
Summary: Here, we describe a fractionation protocol optimized to quantify changes in relative abundance of the chromatin-bound proteome (chromatome) by tandem mass tag multiplexing-based tandem mass spectrometry. It has been applied to yeast cells before
Kiran Challa, Jan Seebacher, Susan M. Gasser   +2 more
doaj  

Fragmentation trees reloaded [PDF]

arXiv, 2014
Metabolites, small molecules that are involved in cellular reactions, provide a direct functional signature of cellular state. Untargeted metabolomics experiments usually relies on tandem mass spectrometry to identify the thousands of compounds in a biological sample. Today, the vast majority of metabolites remain unknown.
arxiv  

Efficient and Scalable Radiative Cooling for Photovoltaics Using Solution‐Processable and Solar‐Transparent Mesoporous Nanoparticles

Advanced Functional Materials, EarlyView.
Graded refractive index (GRI) structures are prepared from the layer‐by‐layer spray coating of the mesoporous SiO2 nanoparticles, showing high solar transparency and thermal emissivity. Under outdoor conditions, after 50 days, the GRI‐coated photovoltaics show on average 6.65 ± 1.48 °C lower than that of the non‐coated references, maintaining 80.9 ± 8 ...
Heesuk Jung, Sung Yoon Min, Byungsoo Kang, Yongseok Yoo, Jihun Jang, Yeoun‐Woo Jang, Hyojeong Choi, Hyeong Won Lee, Swarup Biswas, Yongju Lee, Mansoo Choi, Phillip Lee, Min Seok Jang, Hyeok Kim, Shu Yang   +14 more
wiley   +1 more source

Determination of 4-Methylimidazole in Ammonia Caramel Using Gas Chromatography–Tandem Mass Spectrometry (GC-MS/MS)

Journal of Food Quality, 2018
One of Maillard reaction products formed in the production of ammonia caramel is 4(5)-methylimidazole (4-MeI) classified as carcinogen. A method of 4-MeI determination based on ion-pair extraction and derivatisation with isobutyl chloroformate with ...
Martyna N. Wieczorek, Krzysztof Przygoński, Henryk H. Jeleń   +2 more
doaj   +1 more source