Results 81 to 90 of about 1,188,882 (284)

A novel framework to quantify uncertainty in peptide-tandem mass spectrum matches with application to nanobody peptide identification [PDF]

arXiv, 2021
Nanobodies are small antibody fragments derived from camelids that selectively bind to antigens. These proteins have marked physicochemical properties that support advanced therapeutics, including treatments for SARS-CoV-2. To realize their potential, bottom-up proteomics via liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been proposed ...
arxiv  

Improved isobaric tandem mass tag quantification by ion mobility mass spectrometry.

Rapid Communications in Mass Spectrometry, 2014
RATIONALE Isobaric tandem mass tags are an attractive alternative to mass difference tags and label-free approaches for quantitative proteomics due to the high degree of multiplexing that can be performed with their implementation.
R. Sturm, Christopher B. Lietz, Lingjun Li   +2 more
semanticscholar   +1 more source

Determination of 4-Methylimidazole in Ammonia Caramel Using Gas Chromatography–Tandem Mass Spectrometry (GC-MS/MS)

Journal of Food Quality, 2018
One of Maillard reaction products formed in the production of ammonia caramel is 4(5)-methylimidazole (4-MeI) classified as carcinogen. A method of 4-MeI determination based on ion-pair extraction and derivatisation with isobutyl chloroformate with ...
Martyna N. Wieczorek, Krzysztof Przygoński, Henryk H. Jeleń   +2 more
doaj   +1 more source

Analysis of posttranslational modifications of proteins by tandem mass spectrometry Mass Spectrometry For Proteomics Analysis

BioTechniques, 2006
Protein activity and turnover is tightly and dynamically regulated in living cells. Whereas the three-dimensional protein structure is predominantly determined by the amino acid sequence, posttranslational modification (PTM) of proteins modulates their ...
Martin R. Larsen, Morten B. Trelle, Tine E. Thingholm, Ole N. Jensen   +3 more
doaj   +1 more source

MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis. [PDF]

, 2015
Data-independent acquisition (DIA) in liquid chromatography (LC) coupled to tandem mass spectrometry (MS/MS) provides comprehensive untargeted acquisition of molecular data.
Arita, Masanori, Cajka, Tomas, Fiehn, Oliver, Higgins, Brendan, Ikeda, Kazutaka, Kanazawa, Mitsuhiro, Kind, Tobias, Ma, Yan, Tsugawa, Hiroshi, VanderGheynst, Jean   +9 more
core  

Development and application of an UHPLC-MS/MS method for the simultaneous determination of 17 steroidal hormones in equine serum [PDF]

, 2017
A new, fast and simple analytical method that is able to identify and quantify simultaneously 17 steroid hormones and metabolites (Pregnenolone, 17-OH-Pregnenolone, Progesterone, 17-OH Progesterone, Androsterone, Androstenedione, DHEA, DHEAS ...
Allis, Bonfiglio, Büttler, Caron, Ceglarek, Goros, Guan, Huang, Kaabiaa, Kappas, Ke, Magnisali, Peitzsch, Ray, Schioler, Shao, Stanczyk, Taieb, Thomas, Wong, You   +20 more
core   +1 more source

Seminolipid and its precursor/degradative product, galactosylalkylacylglycerol, in the testis of saposin A- and prosaposin-deficient mice

Journal of Lipid Research, 2003
Sphingolipid activator proteins (saposins A, B, C, and D) are derived from a common precursor protein (prosaposin) and specifically activate in vivo degradation of glycolipids with short carbohydrate chains.
Keiko Tadano-Aritomi, Junko Matsuda, Hirokazu Fujimoto, Kunihiko Suzuki, Ineo Ishizuka   +4 more
doaj  

Determination of Diphenylamine in Gunshot Residue by HPLC-MS/MS

Journal of Forensic Science and Medicine, 2016
A high performance liquid chromatography tandem mass spectrometry/mass spectrometry (HPLC-MS/MS) protocol was developed for the determination of diphenylamine (DPA).
Hongcheng Mei, Yangke Quan, Wenhao Wang, Hong Zhou, Zhanfang Liu, Huixia Shi, Peng Wang   +6 more
doaj   +1 more source

Center-of-Mass iso-Energetic Collision-Induced Decomposition in Tandem Triple Quadrupole Mass Spectrometry

Molecules, 2020
Two scan modes of the triple quadrupole tandem mass spectrometer, namely Collision Induced Dissociation Precursor Ion scan and Neutral Loss scan, allow selectively pinpointing, in a complex mixture, compounds that feature specific chemical groups, which ...
Federico Maria Rubino
doaj   +1 more source

Fragmentation trees reloaded [PDF]

arXiv, 2014
Metabolites, small molecules that are involved in cellular reactions, provide a direct functional signature of cellular state. Untargeted metabolomics experiments usually relies on tandem mass spectrometry to identify the thousands of compounds in a biological sample. Today, the vast majority of metabolites remain unknown.
arxiv