Results 121 to 130 of about 11,164 (212)

Tanshinone IIA Selectively Enhances Hyperpolarization-Activated Cyclic Nucleotide–Modulated (HCN) Channel Instantaneous Current

Journal of Pharmacological Sciences, 2009
.: Tanshinone IIA, one of the main active components from the Chinese herb Danshen, is widely used to treat cardiovascular diseases in Asian countries, especially in China.
Qiansheng Liang, Le Yang, Zhaohua Wang, Sufang Huang, Shusheng Li, Guangtian Yang   +5 more
doaj   +1 more source

Epigenetic Down-Regulation of Sirt 1 via DNA Methylation and Oxidative Stress Signaling Contributes to the Gestational Diabetes Mellitus-Induced Fetal Programming of Heart Ischemia-Sensitive Phenotype in Late Life. [PDF]

, 2019
Rationale: The incidence of gestational diabetes mellitus (GDM) is increasing worldwide. However, whether and how GDM exposure induces fetal programming of adult cardiac dysfunctional phenotype, especially the underlying epigenetic molecular mechanisms ...
Chen, Zewen, Gong, Lei, Li, Yong, Liu, Bailin, Xiao, Daliao, Zhang, Lubo, Zhang, Peng, Zhuang, Jian   +7 more
core  

Tanshinone I as a novel therapeutic agent targeting von Willebrand factor-binding protein to mitigate Staphylococcus aureus pathogenicity

Virulence
Staphylococcus aureus (S. aureus) is a prevalent pathogen responsible for a wide range of diseases in humans, contributing to both hospital-acquired and community-acquired infections.
Shiyu Zhou, Haoyan Zou, Yueshan Xu, Dongbin Guo, Zhengjie Su, Li Wang, Bingmei Wang, Yicheng Zhao, Xiangyang Leng, Yanping Wang   +9 more
doaj   +1 more source

The antitumor effect of tanshinone IIA on anti-proliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line

Acta Pharmaceutica Sinica B, 2015
The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGF/VEGFR signal pathway were investigated.
Jun Xie, Jiahui Liu, Heng Liu, Shihui Liang, Meigui Lin, Yueyu Gu, Taoli Liu, Dongmei Wang, Hui Ge, Sui-lin Mo   +9 more
doaj   +1 more source

Network Properties Revealed during Multi-Scale Calcium Imaging of Seizure Activity in Zebrafish. [PDF]

, 2019
Seizures are characterized by hypersynchronization of neuronal networks. Understanding these networks could provide a critical window for therapeutic control of recurrent seizure activity, i.e., epilepsy.
Baraban, Scott C, Liu, Jing
core   +1 more source

MAPK3-MYB36-ARF1 module regulates the tanshinone formation in Salvia miltiorrhiza

Plant Signaling & Behavior
Salvia miltiorrhiza, known as Danshen, is a traditional Chinese medicinal plant with significant cardiovascular benefits, attributed to its secondary metabolites, particularly tanshinones.
Yongfeng Xie, Hao Liu
doaj   +1 more source

Ferric Citrate Attenuates Cardiac Hypertrophy and Fibrosis in a Rat Model of Chronic Kidney Disease. [PDF]

, 2019
IntroductionChronic kidney disease (CKD) promotes hypertrophy and fibrosis in heart, and increases the risk of cardiovascular mortality. Ferric citrate is a dietary phosphate binder used to control hyperphosphatemia in CKD patients.
Goto, Masaki, Jing, Wanghui, Khazaeli, Mahyar, Lau, Wei Ling, Nunes, Ane CF, Suematsu, Yasunori, Vaziri, Nosratola D   +6 more
core   +1 more source

Content Determination and Chemical Clustering Analysis of Tanshinone and Salvianolic Acid in Salvia spp.

Metabolites
Salvia miltiorrhiza is one of the famous traditional Chinese medicines for treating cardiovascular and cerebrovascular diseases. Tanshinone and phenolic acids are the main active compounds of Salvia miltiorrhiza, whereas the distribution patterns of the ...
Feiyan Wang, Yufeng Bao, Furui Yang, Lu Yuan, Xinchun Han, Yanbo Huang, Yukun Wei, Lei Zhang, Zongqi Yang, Dongfeng Yang   +9 more
doaj   +1 more source

Equality-evaluation of Wakan-yaku (Japanese-Chinese traditional medicines) with liquid chromatography-mass spectrometry (LC-MS) : comparison of constituents of original plants for Chinese traditional medicine "Dan-shen (Tan-j in)" [PDF]

, 2001
Wakan-yaku (Japanese-Chinese traditional medicines) are natural products and its constituents and/or activities depend on several factors, such as species, timing of collection, producing area, individual, etc.
Tezuka Yasuhiro
core   +1 more source

Analysis of the Constituents in Rat Serum after Oral Administration of Fufang Zhenzhu Tiaozhi Capsule by UPLC–Q–TOF–MS/MS [PDF]

, 2011
Xunlong Zhong, Jiao Guo, Laiyou Wang, Duosheng Luo, Weijian Bei, Yuanyuan Chen, Kangqi Yan, Junhui Peng   +7 more
core   +1 more source