Results 131 to 140 of about 5,178 (152)

Tanshinone IIA and tanshinone I production by Trichoderma atroviride D16, an endophytic fungus in Salvia miltiorrhiza

Phytomedicine, 2012
In this study the isolation of an endophytic fungus from the root of the medicinal herb Salvia miltiorrhiza Bunge is reported for the first time. The fungus produced tanshinone I and tanshinone IIA in rich mycological medium (potato dextrose broth) under shake flask and bench scale fermentation conditions.
Qianliang, Ming, Ting, Han, Wenchao, Li, Qiaoyan, Zhang, Hong, Zhang, Chengjian, Zheng, Fang, Huang, Khalid, Rahman, Luping, Qin   +8 more
openaire   +2 more sources

A facile three-step total synthesis of tanshinone I

Journal of Asian Natural Products Research, 2016
A facile synthetic approach for total synthesis of tanshinone I has been accomplished. The key precursor is a novel compound, epoxy phenanthraquinone. And this synthesis of tanshinone I is achieved in only three simple stages, which include Diels-Alder reaction, Δ(2)-Weitz-Scheffer-type epoxidation, and Feist-Bénary reaction from commercially available
Han-Rui, Yang, Jie-Jie, Wang, Peng-Peng, Shao, Si-Yi, Yuan, Xu-Qin, Li   +4 more
openaire   +2 more sources

Enhancement of solubility and dissolution rate of cryptotanshinone, tanshinone I and tanshinone IIA extracted from Salvia miltiorrhiza

Archives of Pharmacal Research, 2012
Cryptotanshinone, tanshinone I and tanshinone IIA are three major components in the extract of Salvia miltiorrhiza with pharmacological significance. However, their effective utilization is limited due to poor water solubility and bioavailability.
Hang, Yu, Robhash Kusam, Subedi, Pushp R, Nepal, Yoon G, Kim, Hoo-Kyun, Choi   +4 more
openaire   +2 more sources

The Correlation ofSalvia miltiorrhizaExtract–Induced Regulation of Osteoclastogenesis with the Amount of Components Tanshinone I, Tanshinone IIA, Cryptotanshinone, and Dihydrotanshinone

Immunopharmacology and Immunotoxicology, 2008
Tanshinone I, tanshinone IIA, cryptotanshinone, and dihydrotanshinone are compounds that have been isolated from the root of Salvia miltiorrhiza (SM), which is also known as "Danshen." The SM extract has been used successfully in China for treating postmenopausal syndrome.
Hae-Kyung, Kim, Eun-Rhan, Woo, Hae-Won, Lee, Hyung-Rae, Park, Hyun-Nam, Kim, Yeon-Kwan, Jung, Je-Yong, Choi, Soo-Wan, Chae, Hyung-Ryong, Kim, Han-Jung, Chae   +9 more
openaire   +2 more sources

Protective properties of tanshinone I against oxidative DNA damage and cytotoxicity

Food and Chemical Toxicology, 2013
Tanshinone I, a naturally occurring diterpene from Danshen, has been shown to possess hepatocyte protective, anticancer, and memory enhancing properties. However, there are few stringent pharmacological tests for neuroprotection of tanshinone I thus far.
Shimiao, Zhou, Wei, Chen, Hongming, Su, Xiaodong, Zheng   +3 more
openaire   +2 more sources

Combination of Microwave Assisted Micellar Extraction and Liquid Chromatography for Determination of Cryptotanshinone, Tanshinone I, and Tanshinone IIA in Salvia Miltiorrhiza Bunge

Journal of Liquid Chromatography & Related Technologies, 2009
Abstract A new method based on the microwave assisted micellar extraction technique (MAME) has been optimized for the extraction of tanshinones from the traditional Chinese medicine-Salvia miltiorrhiza Bunge. Non-ionic surfactant Genapol X-080 solution was employed as extractant.
Zhihong Shi, Yu Wang, Hongyi Zhang
openaire   +1 more source

Tanshinone I induces apoptosis and pro-survival autophagy in gastric cancers

Cancer Chemotherapy and Pharmacology, 2016
To investigate the occurrence of apoptosis and autophagy on human gastric cancer cells after treatment by Tanshinone I, as well as the relationship between them.BGC823 and SGC7901 cells were treated with Tanshinone I; the cell proliferation was measured using CCK-8 and clone formation assay; and the expression of apoptosis- and autophagy-associated ...
Xiaoping, Jing, Yichun, Xu, Weiwei, Cheng, Sheng, Guo, Ya, Zou, Li, He   +5 more
openaire   +2 more sources

[Absorption mechanism of tanshinone II A, cryptotanshinone, tanshinone I and tanshinones extract in rat small intestine in vivo].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2011
To study the absorption mechanism of tanshinones in the roots of Salvia miltiorrhiza as well as the interaction between the components in the effective fraction.The model of intestinal absorption in vivo was used and the concentrations of the tanshinones were determined by HPLC, the apparent absorption constant (K(a)) and half life of absorption (t1/2)
Hongbo, Yan, Qing, Wu, Shouying, Du, Yinhua, Yang, Lin, Zhou, Xuemin, Li   +5 more
openaire   +1 more source

Tanshinone II-A inhibits low density lipoprotein oxidationin vitro

Free Radical Research, 2000
Tanshinone II-A (TSII-A) is a major component of Salvia miltorrhiza Bunge which has long been used for preventing and ameliorating anginal pain in China. However the effect of TSII-A on low density lipoprotein (LDL) oxidation has not been studied. The present study was performed to investigate the effects of TSII-A on LDL oxidation using four oxidizing
X L, Niu, K, Ichimori, X, Yang, Y, Hirota, K, Hoshiai, M, Li, H, Nakazawa   +6 more
openaire   +2 more sources

Simultaneous determination of cryptotanshinone, tanshinone I and tanshinone IIA in traditional Chinese medicinal preparations containing Radix salvia miltiorrhiza by HPLC

Journal of Pharmaceutical and Biomedical Analysis, 2005
A reversed-phase high performance liquid chromatographic method was established for the simultaneous determination of tanshinones in five kinds of traditional Chinese medicinal preparations (TCMPs) containing Radix salvia miltiorrhiza (Chinese herbal name: Danshen).
Zhihong, Shi, Jiantao, He, Tingting, Yao, Wenbao, Chang, Meiping, Zhao   +4 more
openaire   +2 more sources