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Identification of tanshinone I as a natural Cu(II) ionophore
Free Radical Biology and MedicineThe development of Cu(II) ionophores for targeted disruption of aberrant redox homeostasis in cancer cells has been considered an appealing strategy in the field of anticancer research. This study presents the first identification of tanshinone I (Ts1), a natural o-quinone, as a Cu(II) ionophore.
Ya-Long, Zheng +7 more
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Journal of Pharmaceutical and Biomedical Analysis, 2010
A sensitive and specific liquid chromatography-tandem mass spectrometry method (LC-MS) was developed and validated for the separation and simultaneous determination of danshensu, rosmarinic acid and tanshinone compounds including cryptotanshinone, tanshinone I, dihydrotanshinone I and tanshinone IIA in rat plasma.
Yun, Liu +4 more
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A sensitive and specific liquid chromatography-tandem mass spectrometry method (LC-MS) was developed and validated for the separation and simultaneous determination of danshensu, rosmarinic acid and tanshinone compounds including cryptotanshinone, tanshinone I, dihydrotanshinone I and tanshinone IIA in rat plasma.
Yun, Liu +4 more
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Total synthesis of (±)-tanshinol B, tanshinone I, and (±)-tanshindiol B and C
Organic & Biomolecular Chemistry, 2018A concise and efficient approach was established for the divergent total synthesis of (±)-tanshinol B, (±)-tanshindiol B, (±)-tanshindiol C, and tanshinone I in 17–50% overall yield over 3–6 steps.
Fan Wang +8 more
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Antiplasmodial and Antitrypanosomal Activity of Tanshinone-Type Diterpenoids fromSalvia miltiorrhiza
Planta Medica, 2011In a medium throughput screen of 880 plant and fungal extracts for antiprotozoal activity, a dichloromethane extract of Salvia miltiorrhiza roots was active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. With HPLC-based activity profiling in combination with on- and off-line spectroscopic methods (PDA, -MS (n), HR-MS, microprobe
Ślusarczyk, Sylwester +5 more
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China Journal of Chinese Materia Medica, 2010
OBJECTIVE To study the absorption mechanism of tanshinones in the roots of Salvia miltiorrhiza as well as the interaction between the components in the effective fraction. METHOD The model of intestinal absorption in vivo was used and the concentrations of the tanshinones were determined by HPLC, the apparent absorption constant (K(a)) and half life of
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OBJECTIVE To study the absorption mechanism of tanshinones in the roots of Salvia miltiorrhiza as well as the interaction between the components in the effective fraction. METHOD The model of intestinal absorption in vivo was used and the concentrations of the tanshinones were determined by HPLC, the apparent absorption constant (K(a)) and half life of
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Synthesis, characterization and anticancer activity of tanshinone I grafted low molecular chitosan
Glycoconjugate Journal, 2016In this study, we synthesized a novel water-soluble low molecular chitosan (LMC) derivative through Vilsmeier reaction and reductive amination reaction. The derivative was characterized by UV-visible spectroscopy, 1H NMR, FTIR and SEM techniques.
Dongdong, Wang +5 more
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The Plant Journal
SUMMARYDNA methylation plays pivotal roles in regulating gene expression and the secondary metabolism in plants. Salvia miltiorrhiza and Salvia bowleyana are traditional Chinese medicinal plants with roots enriched with tanshinone components. However, the regulatory mechanism of DNA methylation on tanshinone production remains elusive.
Li‐Wei Liu +14 more
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SUMMARYDNA methylation plays pivotal roles in regulating gene expression and the secondary metabolism in plants. Salvia miltiorrhiza and Salvia bowleyana are traditional Chinese medicinal plants with roots enriched with tanshinone components. However, the regulatory mechanism of DNA methylation on tanshinone production remains elusive.
Li‐Wei Liu +14 more
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Abstract A75: Bioactive tanshinones in Salvia miltiorrhiza for prostate cancer chemoprevention
Cancer Prevention Research, 2010Abstract Prostate cancer is the second-leading cause of cancer death in American men. Current therapeutic approaches have made significant progression in the control of prostate cancer progression. On the other hand, conventional therapeutics have variable efficacies and are usually associated with metastatic recurrence and/or high ...
Yi Gong, Yanli Li, Jin-Rong Zhou
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Tanshinone I protects mice from aristolochic acid I-induced kidney injury by induction of CYP1A
Environmental Toxicology and Pharmacology, 2013Hepatic CYP1A especially CYP1A2 plays an important role in the reduction of aristolochic acid I (AAI) nephrotoxicity. In this study, we investigated the effects of tanshinone I, a strong inducer of Cyp1a, on the nephrotoxicity induced by AAI. Histopathology and blood biochemistry assays showed that tanshinone I could reduce AAI-induced acute kidney ...
Chenchen, Feng +7 more
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1008. Tanshinones. Part I. The synthesis of an isomer of tanshinone-I
Journal of the Chemical Society (Resumed), 1961T. J. King, G. Read
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