Results 181 to 190 of about 8,021 (203)
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Total synthesis of tanshinone IIA
Tetrahedron Letters, 2020Abstract A novel synthetic route toward tanshinone IIA has been developed. Key steps involve a base mediated furan ring formation, and an acyloin condensation reaction to construct the ortho-quinone ring.
He Huang +4 more
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Tanshinone-IIA mediated neuroprotection by modulating neuronal pathways
Naunyn-Schmiedeberg's Archives of Pharmacology, 2023The progression of neurological diseases is mainly attributed to oxidative stress, apoptosis, inflammation, and trauma, making them a primary public concern. Since no drugs can stop these neurological disorders from happening, active phytochemical intervention has been suggested as a possible treatment.
Kajal sherawat, Sidharth Mehan
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Tanshinone IIA in Acute Promyelocytic Leukemia
The American Journal of the Medical Sciences, 2012The prognosis of acute promyelocytic leukemia (APL) has been significantly improved by the use of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). However, the utility of these drugs is limited by resistance to ATRA and the side effects of ATO.
Jian, Li +3 more
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Studies on the spectroscopic behavior of cryptotanshinone, tanshinone IIA, and tanshinone I
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2004A comparative study on the spectroscopic behavior of cryptotanshinone (CTan), tanshinone IIA (Tan IIA), and tanshinone I (Tan I) has been investigated, including UV-Vis absorption, low temperature phosphorescence (LTP), low temperature fluorescence (LTF), paper substrate-room temperature phosphorescence (PS-RTP), paper substrate-room temperature ...
Jun-Fen, Li +4 more
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Synthesis and vasodilative activity of tanshinone IIA derivatives
Bioorganic & Medicinal Chemistry Letters, 2010A series of 2,2'-(substituted methylene)bis-(1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione) derivatives were synthesized by the reaction of tanshinone IIA (D(1)) and aromatic aldehyde in the presence of p-TsOH. Bromination derivative of D(1) and hydrolysis product of cryptotanshinone (D(2)) were also prepared in this work ...
Yue-Feng, Bi +5 more
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Tanshinone IIA Attenuates Sevoflurane Neurotoxicity in Neonatal Mice
Anesthesia & Analgesia, 2017BACKGROUND: Sevoflurane is the most widely used inhalational anesthetic in pediatric medicine. Despite this, sevoflurane has been reported to exert potentially neurotoxic effects on the developing brain. Clinical interventions and treatments for these effects are limited.
Yimeng, Xia +8 more
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Cardiovascular actions and therapeutic potential of tanshinone IIA
Atherosclerosis, 2012Tanshinone IIA (TS), a pharmacologically active component isolated from the rhizome of the Chinese herb Salvia miltiorrhiza Bunge (Danshen), has been clinically used in Asian countries for the prevention and treatment of coronary heart disease. Recently, the pharmacological properties of TS in the cardiovascular system have attracted great interest ...
Gao, Si +5 more
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Journal of Nanoscience and Nanotechnology, 2019
The basic problems of the low dissolution rate of Tanshinone IIA (TSN) and the instability and precipitation of sodium tanshinone IIA sulfonate (STS) injection limit their usage in clinical. For these facts, the study aims to improve the dissolution rate of TSN and to enhance the sustained release effects of TSN and STS by using SBA-15 mesoporous ...
Xun, Liu +5 more
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The basic problems of the low dissolution rate of Tanshinone IIA (TSN) and the instability and precipitation of sodium tanshinone IIA sulfonate (STS) injection limit their usage in clinical. For these facts, the study aims to improve the dissolution rate of TSN and to enhance the sustained release effects of TSN and STS by using SBA-15 mesoporous ...
Xun, Liu +5 more
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Design, synthesis and vasodilative activity of tanshinone IIA derivatives
Bioorganic & Medicinal Chemistry Letters, 2012A new series of tanshinone IIA (DIIA) derivatives were synthesized through the reaction of brominated tanshinone IIA (1-Br DIIA) and aromatic acids in the presence of K(2)CO(3). Twenty compounds were synthesized, and all of them were novel. Vasodilative activities for synthesized compounds were valuated in vitro on the contractile response of vascular ...
Yue-Feng, Bi +6 more
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Preparation and physicochemical characterizations of tanshinone IIA solid dispersion
Archives of Pharmacal Research, 2011This investigation describes a novel approach to prepare solid dispersions of tanshinone IIA using a laboratory-scale planetary ball mill. Poloxamer 188 was employed as the surfactant carrier to improve the solubility and dissolution of the poorly soluble drug, tanshinone IIA.
Xia, Zhao +4 more
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