Results 191 to 200 of about 116,988 (242)

Effects and mechanisms of tanshinone IIA on PTSD-like symptoms

Phytomedicine, 2023
In recent years, Salvia miltiorrhiza and its active substances have remarkably progressed in treating central neurological disorders. Tanshinone IIA (TSA) is an active ingredient derived from the rhizome of Salvia miltiorrhiza that has been found to alleviate the symptoms of several psychiatric illnesses.
Kai-Bin Hu, Xiu-Min Lu, Hai-Yan Wang, Hui-Lin Liu, Qing-Yun Wu, Ping Liao, Sen Li, Zai-Yun Long, Yong-Tang Wang   +8 more
openaire   +2 more sources

Tanshinone IIA in Acute Promyelocytic Leukemia

The American Journal of the Medical Sciences, 2012
The prognosis of acute promyelocytic leukemia (APL) has been significantly improved by the use of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). However, the utility of these drugs is limited by resistance to ATRA and the side effects of ATO.
Jian, Li, Kaiji, Zhang, Wentong, Meng, Yiming, Yang   +3 more
openaire   +2 more sources

Synthesis and vasodilative activity of tanshinone IIA derivatives

Bioorganic & Medicinal Chemistry Letters, 2010
A series of 2,2'-(substituted methylene)bis-(1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione) derivatives were synthesized by the reaction of tanshinone IIA (D(1)) and aromatic aldehyde in the presence of p-TsOH. Bromination derivative of D(1) and hydrolysis product of cryptotanshinone (D(2)) were also prepared in this work ...
Yue-Feng, Bi, Hai-Wei, Xu, Xiao-Qing, Liu, Xiao-Juan, Zhang, Zhen-Ji, Wang, Hong-Min, Liu   +5 more
openaire   +2 more sources

Metabolism of Tanshinone IIA, Cryptotanshinone and Tanshinone I from Radix Salvia Miltiorrhiza in Zebrafish [PDF]

Molecules, 2012
The study aimed to investigate the potential of zebrafish in imitating mammal phase I metabolism of natural compounds. Three diterpenoid quinones from Radix Salvia miltiorrhiza, namely tanshinone IIA (TIIA), cryptotanshinone (Cry) and tanshinone I (TI) were selected as model compounds, and their metabolites mediated by zebrafish were characterized ...
Luan Shu, Ping Li
exaly   +4 more sources

Cardiovascular actions and therapeutic potential of tanshinone IIA

Atherosclerosis, 2012
Tanshinone IIA (TS), a pharmacologically active component isolated from the rhizome of the Chinese herb Salvia miltiorrhiza Bunge (Danshen), has been clinically used in Asian countries for the prevention and treatment of coronary heart disease. Recently, the pharmacological properties of TS in the cardiovascular system have attracted great interest ...
Gao, Si, Liu, Zhiping, Li, Hong, Little, Peter J., Liu, Peiqing, Xu, Suowen   +5 more
openaire   +5 more sources

Salvianolic acid B and tanshinone IIA synergistically improve early diabetic nephropathy through regulating PI3K/Akt/NF-κB signaling pathway.

Journal of Ethnopharmacology, 2023
ETHNOPHARMACOLOGICAL RELEVANCE Diabetic nephropathy (DN) is one of the most common and serious complications of diabetes, which lacks effective treatment. Salviae Miltiorrhizae Radix Et Rhizoma is one of the key compatible traditional Chinese medicine in
Zhuo Xu, Ke Cai, S. Su, Yue Zhu, Feng Liu, Jin-Ao Duan   +5 more
semanticscholar   +1 more source

The Construction of Sustained-Release Systems of Tanshinone IIA and Sodium Tanshinone IIA Sulfonate by SBA-15 Mesoporous Material

Journal of Nanoscience and Nanotechnology, 2019
The basic problems of the low dissolution rate of Tanshinone IIA (TSN) and the instability and precipitation of sodium tanshinone IIA sulfonate (STS) injection limit their usage in clinical. For these facts, the study aims to improve the dissolution rate of TSN and to enhance the sustained release effects of TSN and STS by using SBA-15 mesoporous ...
Xun, Liu, Yan-Li, Gu, Bing-Bing, Zhang, Qiu-Mei, Dong, Yong-Le, Li, Hui-Min, Wang   +5 more
openaire   +2 more sources

Tanshinone IIA modulates Sirt5 and Metll3 interaction to govern mitochondria-endoplasmic reticulum unfolded protein response in coronary microvascular injury.

Phytomedicine
BACKGROUND Traditional Chinese medicine (TCM) has demonstrated significant advantages in the treatment of coronary microvascular injury, offering novel therapeutic strategies for cardiovascular diseases.
Xiang-Yi Pu, Qiaomin Wu, Zhao-Qi Yan, Siyuan Zhou, Qin Zhang, Xinai Zhang, Yongyuan Cai, Zhi-Ming Liu, Ru-Xiu Liu, Xing Chang   +9 more
semanticscholar   +1 more source

A simply triggered peptide-based hydrogel as an injectable nanocarrier of tanshinone IIA and tanshinones

Chemical Communications, 2017
An easily self-assembled and gelated octa-peptide FHFDFHFD was chosen as a novel drug delivery system (DDS) for both tanshinone IIA and total tanshinone extract.
Yajun, Yin, Can, Wu, Junling, Wang, Fengjuan, Song, Wanqing, Yue, Wenying, Zhong   +5 more
openaire   +2 more sources

Tanshinone IIA attenuates cerebral-ischemia-reperfusion-induced neuroinflammation by inhibiting the TLR4/NF-κB signaling cascade: A study integrating network pharmacology, bioinformatics, and experimental validation.

Phytomedicine
BACKGROUND Tanshinone IIA is the primary compound of Salvia miltiorrhiza, has neuroprotective and antioxidant properties. However, its anti-inflammatory role in cerebral ischemia-reperfusion injury is not well understood.
Chenxi Zhou, Zhexuan Yu, Tian-Xue Chen, Qianqian Chen, Yangyang Zhang, Jia-Wei Cai, Ceng-lin Xu, Li Yu   +7 more
semanticscholar   +1 more source