Results 211 to 220 of about 116,988 (242)

Tanshinone IIA normalized hepatocellular carcinoma vessels and enhanced PD-1 inhibitor efficacy by inhibiting ELTD1.

Phytomedicine, 2023
BACKGROUND Hepatocellular carcinoma responds poorly to immune checkpoint inhibitors, such as PD-1 inhibitors, primarily due to the low infiltration capacity of TILs in the TME.
Dengxuan Mao, Hong Wang, Hong Guo, Xiao-Yu Che, Miaoying Chen, Xia Li, Yu-Ping Liu, Jie-Ge Huo, Yan Chen   +8 more
semanticscholar   +1 more source

Tanshinone IIA induces ER stress and JNK activation to inhibit tumor growth and enhance anti-PD-1 immunotherapy in non-small cell lung cancer.

Phytomedicine
BACKGROUND Non-small cell lung cancer (NSCLC) remains at the forefront of new cancer cases, and there is an urgent need to find new treatments or improve the efficacy of existing therapies.
Yi-Zhong Zhang, Huanling Lai, Chen Huang, Ze-Bo Jiang, Haoxin Yan, Xuan-Run Wang, Chun Xie, Ju-Min Huang, Wenkang Ren, Jia-Xin Li, Zhiran Zhai, X. Yao, Qibiao Wu, Elaine Lai-Han Leung   +13 more
semanticscholar   +1 more source

Design, synthesis and vasodilative activity of tanshinone IIA derivatives

Bioorganic & Medicinal Chemistry Letters, 2012
A new series of tanshinone IIA (DIIA) derivatives were synthesized through the reaction of brominated tanshinone IIA (1-Br DIIA) and aromatic acids in the presence of K(2)CO(3). Twenty compounds were synthesized, and all of them were novel. Vasodilative activities for synthesized compounds were valuated in vitro on the contractile response of vascular ...
Yue-Feng, Bi, Zhen-Ji, Wang, Ruo-Fei, Guan, Yu-Ting, Ye, Yuan-Yuan, Chen, Yan-Bing, Zhang, Hong-Min, Liu   +6 more
openaire   +2 more sources

Activation of SIRT3 by Tanshinone IIA ameliorates renal fibrosis by suppressing the TGF-β/TSP-1 pathway and attenuating oxidative stress.

Cellular Signalling
Although doxorubicin (DOX) is a common chemotherapeutic drug, the serious nephrotoxicity caused by DOX-induced renal fibrosis remains a considerable clinical problem.
Yifeng Fan, Shengyu Kang, Tong Shao, Linhao Xu, Jian Chen   +4 more
semanticscholar   +1 more source

Tanshinone IIA Attenuates Sevoflurane Neurotoxicity in Neonatal Mice

Anesthesia & Analgesia, 2017
BACKGROUND: Sevoflurane is the most widely used inhalational anesthetic in pediatric medicine. Despite this, sevoflurane has been reported to exert potentially neurotoxic effects on the developing brain. Clinical interventions and treatments for these effects are limited.
Yimeng, Xia, Heng, Xu, Chenfei, Jia, Xiaodong, Hu, Yu, Kang, Xiaoxuan, Yang, Qingsheng, Xue, Guorong, Tao, Buwei, Yu   +8 more
openaire   +2 more sources

Preparation, Characterization and Cytotoxicity Evaluation of Tanshinone IIA Nanoemulsions

Journal of Biomedical Nanotechnology, 2011
Tanshinone IIA (TA) is a major active component of Danshen (Salvia miltiorrhiza bunge), a well-known traditional Chinese medicine. In this paper, we describe an optimal method for preparing TA nanoemulsions (TA-NEs) to solve the problems of TA's poor solubility in water and insufficient dissolution rate.
Li-Ching, Chang, Chi-Lien, Wu, Ching-Wen, Liu, Wen-Ho, Chuo, Ping-Chia, Li, Tong-Rong, Tsai   +5 more
openaire   +2 more sources

Tanshinone IIA alleviates inflammation-induced skeletal muscle atrophy by regulating mitochondrial dysfunction.

Archives of Biochemistry and Biophysics
Skeletal muscle atrophy, characterized by loss of muscle mass and function, is often linked to systemic inflammation. Tanshinone IIA (Tan IIA), a major active constituent of Salvia miltiorrhiza, has anti-inflammatory and antioxidant properties.
Dong Han, Yun-Biao Chen, Kai Zhao, Hong-Zhou Li, Xing-Yu Chen, Guo-Zheng Zhu, Chen Tu, Jia-Wen Gao, Jing-Shen Zhuang, Zhi-Yong Wu, Zhao-Ming Zhong   +10 more
semanticscholar   +1 more source

Tanshinone IIA Against Cerebral Ischemic Stroke and Ischemia-Reperfusion Injury: A Review of the Current Documents.

Mini-Reviews in Medical Chemistry
Stroke is a well-known neurological disorder that carries significant morbidity and mortality rates worldwide. Cerebral Ischemic Stroke (CIS), the most common subtype of stroke, occurs when thrombosis or emboli form elsewhere in the body and travel to ...
Reza Arefnezhad, Alireza Nejabat, Fatemeh Behjati, Mona Torkamanche, Hooman Zarei, Motahhareh Yekkehbash, Fatemeh Afsharmanesh, Z. Niknam, T. Jamialahmadi, A. Sahebkar   +9 more
semanticscholar   +1 more source

Tanshinone IIA, a Component of Salvia miltiorrhiza Bunge, Attenuated Sepsis-induced Liver Injury via the SIRT1/Sestrin2/HO-1 Signaling Pathway.

Journal of Ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE As a traditional Chinese medicine, Salvia miltiorrhiza Bunge has been widely used to treat ischemic and inflammation-related diseases for more than 2,000 years. S.
Wen-Cong Tian, Peng Song, Junhao Zang, Jia Zhao, Yan-Hong Liu, Chun-Tao Wang, Hong Fang, Hongzhi Wang, Yongjie Zhao, Xingqiang Liu, Yang Gao, Lei Cao   +11 more
semanticscholar   +1 more source

Tanshinone IIA acts as a regulator of lipogenesis to overcome osimertinib acquired resistance in lung cancer.

Biochemical Pharmacology
Osimertinib is a novel epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), acting as the first-line medicine for advanced EGFR-mutated NSCLC.
Lin Cao, Zhiyan Qin, Ting Yu, Xupeng Bai, Shi-Qin Jiang, Dai-Fei Wang, Fangqing Ning, Min Huang, Jing Jin   +8 more
semanticscholar   +1 more source