Results 211 to 220 of about 79,005 (262)

Tanshinone IIA in Acute Promyelocytic Leukemia

The American Journal of the Medical Sciences, 2012
The prognosis of acute promyelocytic leukemia (APL) has been significantly improved by the use of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). However, the utility of these drugs is limited by resistance to ATRA and the side effects of ATO.
Jian, Li, Kaiji, Zhang, Wentong, Meng, Yiming, Yang   +3 more
openaire   +2 more sources

Targeted pH-responsive chitosan nanogels with Tanshinone IIA for enhancing the antibacterial/anti-biofilm efficacy.

International Journal of Biological Macromolecules, 2023
Persistent bacterial infection caused by biofilms is one of the most serious problems that threatened human health. The development of antibacterial agents remains a challenge to penetrate biofilm and effectively treat the underlying bacterial infection.
Mingxia Wang, T. Muhammad, Huiling Gao, Jianzhang Liu, Hao Liang   +4 more
semanticscholar   +1 more source

Tanshinone IIA inhibited intermittent hypoxia induced neuronal injury through promoting autophagy via AMPK-mTOR signaling pathway.

Journal of Ethnopharmacology, 2023
ETHNOPHARMACOLOGICAL RELEVANCE Chronic intermittent hypoxia (CIH) is the primary pathophysiological process of obstructive sleep apnea (OSA) and is closely linked to neurocognitive dysfunction.
Jianchao Si, Bingbing Liu, Kerong Qi, Xue Chen, Dongli Li, Shengchang Yang, Ensheng Ji   +6 more
semanticscholar   +1 more source

Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1

Phytotherapy Research, 2023
Diabetic cardiomyopathy (DCM) is a common complication in patients with diabetes, and ultimately leads to heart failure. Endoplasmic reticulum stress (ERS) induced by abnormal glycolipid metabolism is a critical factor that affects the occurrence and ...
Shun Wu, Dingchun Lu, Babu Gajendran, Qilan Hu, Jian Zhang, Sheng-Ming Wang, Minzhen Han, Yi-ni Xu, Xiang-chun Shen   +8 more
semanticscholar   +1 more source

Studies on the spectroscopic behavior of cryptotanshinone, tanshinone IIA, and tanshinone I

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2004
A comparative study on the spectroscopic behavior of cryptotanshinone (CTan), tanshinone IIA (Tan IIA), and tanshinone I (Tan I) has been investigated, including UV-Vis absorption, low temperature phosphorescence (LTP), low temperature fluorescence (LTF), paper substrate-room temperature phosphorescence (PS-RTP), paper substrate-room temperature ...
Jun-Fen, Li, Yu-Xia, Wei, Zhi-Cheng, Xu, Chuan, Dong, Shao-Min, Shuang   +4 more
openaire   +2 more sources

Synthesis and vasodilative activity of tanshinone IIA derivatives

Bioorganic & Medicinal Chemistry Letters, 2010
A series of 2,2'-(substituted methylene)bis-(1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione) derivatives were synthesized by the reaction of tanshinone IIA (D(1)) and aromatic aldehyde in the presence of p-TsOH. Bromination derivative of D(1) and hydrolysis product of cryptotanshinone (D(2)) were also prepared in this work ...
Yue-Feng, Bi, Hai-Wei, Xu, Xiao-Qing, Liu, Xiao-Juan, Zhang, Zhen-Ji, Wang, Hong-Min, Liu   +5 more
openaire   +2 more sources

Tanshinone IIA Attenuates Sevoflurane Neurotoxicity in Neonatal Mice

Anesthesia & Analgesia, 2017
BACKGROUND: Sevoflurane is the most widely used inhalational anesthetic in pediatric medicine. Despite this, sevoflurane has been reported to exert potentially neurotoxic effects on the developing brain. Clinical interventions and treatments for these effects are limited.
Yimeng, Xia, Heng, Xu, Chenfei, Jia, Xiaodong, Hu, Yu, Kang, Xiaoxuan, Yang, Qingsheng, Xue, Guorong, Tao, Buwei, Yu   +8 more
openaire   +2 more sources

Tanshinone IIA modulates Sirt5 and Metll3 interaction to govern mitochondria-endoplasmic reticulum unfolded protein response in coronary microvascular injury.

Phytomedicine
BACKGROUND Traditional Chinese medicine (TCM) has demonstrated significant advantages in the treatment of coronary microvascular injury, offering novel therapeutic strategies for cardiovascular diseases.
Xiangyi Pu, Qiaomin Wu, Zhaoqi Yan, Siyuan Zhou, Qin Zhang, Xinai Zhang, Yongyuan Cai, Zhiming Liu, Ruxiu Liu, Xing Chang   +9 more
semanticscholar   +1 more source

Tanshinone IIA, the key compound in Salvia miltiorrhiza, improves cognitive impairment by upregulating Aβ-degrading enzymes in APP/PS1 mice.

International Journal of Biological Macromolecules, 2023
In Alzheimer's disease (AD), amyloid-beta (Aβ) plays a crucial role in pathogenesis. Clearing Aβ from the brain is considered as a key therapeutic strategy. Previous studies indicated that Salvia miltiorrhiza (Danshen) could protect against AD.
Xiao-qi Liu, Tian Hu, Guangping Wu, Li Qiao, Ye-Feng Cai, Qi Wang, Shi-Jie Zhang   +6 more
semanticscholar   +1 more source

Tanshinone IIA attenuates cerebral-ischemia-reperfusion-induced neuroinflammation by inhibiting the TLR4/NF-κB signaling cascade: A study integrating network pharmacology, bioinformatics, and experimental validation.

Phytomedicine
BACKGROUND Tanshinone IIA is the primary compound of Salvia miltiorrhiza, has neuroprotective and antioxidant properties. However, its anti-inflammatory role in cerebral ischemia-reperfusion injury is not well understood.
Chenxi Zhou, Zhexuan Yu, Tianxue Chen, Qianqian Chen, Yangyang Zhang, Jiawei Cai, Ceng-lin Xu, Li Yu   +7 more
semanticscholar   +1 more source