Results 231 to 240 of about 79,005 (262)

Tanshinone IIA: A phytochemical as a promising drug candidate for neurodegenerative diseases.

Pharmacological Research, 2021
Tanshinones, lipophilic diterpenes isolated from the rhizome of Salvia miltiorrhiza, have diverse pharmacological activities against human ailments including neurological diseases.
Lalita Subedi, B. Gaire
semanticscholar   +1 more source

Preparation and physicochemical characterizations of tanshinone IIA solid dispersion

Archives of Pharmacal Research, 2011
This investigation describes a novel approach to prepare solid dispersions of tanshinone IIA using a laboratory-scale planetary ball mill. Poloxamer 188 was employed as the surfactant carrier to improve the solubility and dissolution of the poorly soluble drug, tanshinone IIA.
Xia, Zhao, Xin, Liu, Lishe, Gan, Changxin, Zhou, Jianxia, Mo   +4 more
openaire   +2 more sources

Tanshinone IIA: Pharmacology, Total Synthesis, and Progress in Structure-modifications

Current Medicinal Chemistry, 2022
: Tanshinone IIA, a major bioactive constituent of Danshen, a Chinese herbal medicine, has gained extensive exploration owing to its unique structural features and multiple promising biological activities. This review focuses on the pharmacology, total synthesis, and structural modifications of tanshinone IIA.
Xing, Huang, Hao, Deng, Qing-Kun, Shen, Zhe-Shan, Quan   +3 more
openaire   +2 more sources

Tanshinone IIA Against Cerebral Ischemic Stroke and Ischemia-Reperfusion Injury: A Review of the Current Documents.

Mini-Reviews in Medical Chemistry
Stroke is a well-known neurological disorder that carries significant morbidity and mortality rates worldwide. Cerebral Ischemic Stroke (CIS), the most common subtype of stroke, occurs when thrombosis or emboli form elsewhere in the body and travel to ...
Reza Arefnezhad, Alireza Nejabat, Fatemeh Behjati, Mona Torkamanche, Hooman Zarei, Motahhareh Yekkehbash, Fatemeh Afsharmanesh, Zahra Niknam, T. Jamialahmadi, A. Sahebkar   +9 more
semanticscholar   +1 more source

Effects and mechanisms of tanshinone IIA on PTSD-like symptoms

Phytomedicine, 2023
In recent years, Salvia miltiorrhiza and its active substances have remarkably progressed in treating central neurological disorders. Tanshinone IIA (TSA) is an active ingredient derived from the rhizome of Salvia miltiorrhiza that has been found to alleviate the symptoms of several psychiatric illnesses.
Kai-Bin Hu, Xiu-Min Lu, Hai-Yan Wang, Hui-Lin Liu, Qing-Yun Wu, Ping Liao, Sen Li, Zai-Yun Long, Yong-Tang Wang   +8 more
openaire   +2 more sources

Preparation, Characterization and Cytotoxicity Evaluation of Tanshinone IIA Nanoemulsions

Journal of Biomedical Nanotechnology, 2011
Tanshinone IIA (TA) is a major active component of Danshen (Salvia miltiorrhiza bunge), a well-known traditional Chinese medicine. In this paper, we describe an optimal method for preparing TA nanoemulsions (TA-NEs) to solve the problems of TA's poor solubility in water and insufficient dissolution rate.
Li-Ching, Chang, Chi-Lien, Wu, Ching-Wen, Liu, Wen-Ho, Chuo, Ping-Chia, Li, Tong-Rong, Tsai   +5 more
openaire   +2 more sources

Preparation, Characterization Evaluation of Tanshinone IIA Lipid Microspere and Comparative Study of Pharmacokinetics with Sodium Tanshinone IIA Sulfonate Injection

Advanced Materials Research, 2013
In this study, Tanshinone IIA lipid microspere (Tan-IIA-LM) was successfully prepared by an ultrasonic and high-pressure homogenization method. The particle size, zeta potential, drug entrapment efficiency and morphological properties of Tan-IIA-LM were characterized in detail.
Xin Li Liang, Meng Liang Zhu, Yun Chao Cao, Guo Wei Zhao, Qie Ying Jiang, Li Jun Zhao, Zheng Gen Liao   +6 more
openaire   +1 more source

A simply triggered peptide-based hydrogel as an injectable nanocarrier of tanshinone IIA and tanshinones

Chemical Communications, 2017
An easily self-assembled and gelated octa-peptide FHFDFHFD was chosen as a novel drug delivery system (DDS) for both tanshinone IIA and total tanshinone extract.
Yajun, Yin, Can, Wu, Junling, Wang, Fengjuan, Song, Wanqing, Yue, Wenying, Zhong   +5 more
openaire   +2 more sources

Sodium Tanshinone IIA sulfonate improves post-ischemic angiogenesis in hyperglycemia

Biochemical and Biophysical Research Communications, 2019
Diabetes is a strong risk factor of peripheral arterial disease (PAD), and also leads to impaired perfusion recovery in the ischemic limb, which eventually results in poor outcomes in PAD patients. Sodium Tanshinone IIA Sulfonate (STS), a monomer from herbs, has been shown to improve the outcomes in a variety of ischemic disease including myocardial ...
Lingdan, Chen, Wenjun, He, Bin, Peng, Mingjie, Yuan, Neng, Wang, Jian, Wang, Wenju, Lu, Tao, Wang   +7 more
openaire   +2 more sources

Tanshinone IIA Improves Intestinal Barrier Integrity in Septic Rats

Surgical Infections
Aims: The present work aimed to examine impact of tanshinone IIA on intestinal barrier in sepsis and to explore the underpinning mechanisms. Materials and Methods: Sepsis induction in Sprague-Dawley (SD) rats was conducted via cecal ligation and puncture (CLP), with subsequent intraperitoneal injection of tanshinone IIA.
Lvzhao, Liao, Yiying, Xiao, Xi, Xing, Xi, Wang, Jianming, Zhou, Wenjing, Li, Sixu, Pan, Nafei, Xu, Ronglin, Jiang   +8 more
openaire   +2 more sources