Results 221 to 230 of about 79,005 (262)

Tanshinone IIA promotes ferroptosis in cutaneous melanoma via STAT1-mediated upregulation of PTGS2 expression.

Phytomedicine
BACKGROUND Melanoma is highly aggressive, metastatic with a poor prognosis. Despite significant advances in targeted therapies and immunotherapies, their efficiency limited by drug resistance.
Shuyue Chen, Peiting Li, Ke Shi, Shijie Tang, Wancong Zhang, Cong Peng, Tianyu Li, Huiqing Xie, Can Liu, Jianda Zhou   +9 more
semanticscholar   +1 more source

Tanshinone IIA normalized hepatocellular carcinoma vessels and enhanced PD-1 inhibitor efficacy by inhibiting ELTD1.

Phytomedicine, 2023
BACKGROUND Hepatocellular carcinoma responds poorly to immune checkpoint inhibitors, such as PD-1 inhibitors, primarily due to the low infiltration capacity of TILs in the TME.
Dengxuan Mao, Hong Wang, Hong Guo, Xiaoyu Che, Miaoying Chen, Xia Li, Yuping Liu, Jiege Huo, Yan Chen   +8 more
semanticscholar   +1 more source

Cardiovascular actions and therapeutic potential of tanshinone IIA

Atherosclerosis, 2012
Tanshinone IIA (TS), a pharmacologically active component isolated from the rhizome of the Chinese herb Salvia miltiorrhiza Bunge (Danshen), has been clinically used in Asian countries for the prevention and treatment of coronary heart disease. Recently, the pharmacological properties of TS in the cardiovascular system have attracted great interest ...
Gao, Si, Liu, Zhiping, Li, Hong, Little, Peter J., Liu, Peiqing, Xu, Suowen   +5 more
openaire   +3 more sources

Tanshinone IIA alleviate atherosclerosis and hepatic steatosis via down-regulation of MAPKs/NF-κB signaling pathway.

International Immunopharmacology
OBJECTIVES Tanshinone IIA (Tan IIA) exhibits therapeutic potential for atherosclerosis (AS) and hepatic steatosis (HS). The study aims to explore the mechanisms underlying the anti-atherosclerosis and anti-hepatic steatosis effects of Tan IIA.
Yifan Zhang, Jiarou Wang, Shuo Yang, Haixin Kou, Ping Liu   +4 more
semanticscholar   +1 more source

Tanshinone IIA mitigates postoperative cognitive dysfunction in aged rats by inhibiting hippocampal inflammation and ferroptosis: role of Nrf2/SLC7A11/GPX4 axis activation.

Neurotoxicology
OBJECTIVE Postoperative cognitive dysfunction (POCD) is a common and debilitating complication in elderly patients following surgery, leading to increased morbidity and reduced quality of life.
Yan Yang, Bo Wang, Yichen Jiang, Wan Fu
semanticscholar   +1 more source

Tanshinone IIA Ameliorates Myocardial Ischemia–Reperfusion Injury via Activating HDAC1‐Repressed Nrf2‐xCT/Gpx4/HO‐1 Axis

Chemical Biology and Drug Design
Myocardial ischemia/reperfusion injury (MIRI) brings secondary injury to heart tissues and involves complicated pathophysiological activities, such as cell death, oxidative stress, and inflammation.
Ke Yan, Shenghui Yu, Xiang Gao, Lei Li, Li Ding   +4 more
semanticscholar   +1 more source

The Construction of Sustained-Release Systems of Tanshinone IIA and Sodium Tanshinone IIA Sulfonate by SBA-15 Mesoporous Material

Journal of Nanoscience and Nanotechnology, 2019
The basic problems of the low dissolution rate of Tanshinone IIA (TSN) and the instability and precipitation of sodium tanshinone IIA sulfonate (STS) injection limit their usage in clinical. For these facts, the study aims to improve the dissolution rate of TSN and to enhance the sustained release effects of TSN and STS by using SBA-15 mesoporous ...
Xun, Liu, Yan-Li, Gu, Bing-Bing, Zhang, Qiu-Mei, Dong, Yong-Le, Li, Hui-Min, Wang   +5 more
openaire   +2 more sources

Design, synthesis and vasodilative activity of tanshinone IIA derivatives

Bioorganic & Medicinal Chemistry Letters, 2012
A new series of tanshinone IIA (DIIA) derivatives were synthesized through the reaction of brominated tanshinone IIA (1-Br DIIA) and aromatic acids in the presence of K(2)CO(3). Twenty compounds were synthesized, and all of them were novel. Vasodilative activities for synthesized compounds were valuated in vitro on the contractile response of vascular ...
Yue-Feng, Bi, Zhen-Ji, Wang, Ruo-Fei, Guan, Yu-Ting, Ye, Yuan-Yuan, Chen, Yan-Bing, Zhang, Hong-Min, Liu   +6 more
openaire   +2 more sources

Tanshinone IIA induces ER stress and JNK activation to inhibit tumor growth and enhance anti-PD-1 immunotherapy in non-small cell lung cancer.

Phytomedicine
BACKGROUND Non-small cell lung cancer (NSCLC) remains at the forefront of new cancer cases, and there is an urgent need to find new treatments or improve the efficacy of existing therapies.
Yizhong Zhang, Huanling Lai, Chen Huang, Ze-bo Jiang, Haoxin Yan, Xuan-Run Wang, Chun Xie, Jumin Huang, Wenkang Ren, Jia-Xin Li, Zhiran Zhai, X. Yao, Qi-Biao Wu, Elaine Lai-Han Leung   +13 more
semanticscholar   +1 more source

Activation of SIRT3 by Tanshinone IIA ameliorates renal fibrosis by suppressing the TGF-β/TSP-1 pathway and attenuating oxidative stress.

Cellular Signalling
Although doxorubicin (DOX) is a common chemotherapeutic drug, the serious nephrotoxicity caused by DOX-induced renal fibrosis remains a considerable clinical problem.
Yifeng Fan, Shengyu Kang, Tong Shao, Linhao Xu, Jian Chen   +4 more
semanticscholar   +1 more source