Results 171 to 180 of about 2,942 (199)

Synthesis of tanshinones

Tetrahedron, 1971
Abstract Tanshinone-II and cryptotanshinone have been synthesized from 1,2,4-trimethoxybenzene by fourteen steps.
M. Tateishi, T. Kusumi, H. Kakisawa
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Total Synthesis of Tanshinone I

Journal of Natural Products, 2017
A novel total synthesis of tanshinone I (1) via the intermediate 3-hydroxy-8-methyl-1,4-phenanthrenedione (8) is described. The low overall yields and the use of expensive reagents in the synthesis process were minimized by the use of the Diels-Alder reaction to directly construct the 1,4-phenanthrenedione scaffold, providing tanshinone I (1) in only ...
Nan Wu, Wei-Cong Ma, Sheng-Jun Mao, Yong Wu, Hui Jin   +4 more
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Studies on the spectroscopic behavior of cryptotanshinone, tanshinone IIA, and tanshinone I

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2004
A comparative study on the spectroscopic behavior of cryptotanshinone (CTan), tanshinone IIA (Tan IIA), and tanshinone I (Tan I) has been investigated, including UV-Vis absorption, low temperature phosphorescence (LTP), low temperature fluorescence (LTF), paper substrate-room temperature phosphorescence (PS-RTP), paper substrate-room temperature ...
Jun-Fen, Li, Yu-Xia, Wei, Zhi-Cheng, Xu, Chuan, Dong, Shao-Min, Shuang   +4 more
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Total synthesis of tanshinone IIA

Tetrahedron Letters, 2020
Abstract A novel synthetic route toward tanshinone IIA has been developed. Key steps involve a base mediated furan ring formation, and an acyloin condensation reaction to construct the ortho-quinone ring.
He Huang, Chuanjun Song, Zhen Wang, Mengyang Li, Junbiao Chang   +4 more
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Tanshinone IIA in Acute Promyelocytic Leukemia

The American Journal of the Medical Sciences, 2012
The prognosis of acute promyelocytic leukemia (APL) has been significantly improved by the use of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). However, the utility of these drugs is limited by resistance to ATRA and the side effects of ATO.
Jian, Li, Kaiji, Zhang, Wentong, Meng, Yiming, Yang   +3 more
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Isolation and Bioactivity of New Tanshinones

Journal of Natural Products, 1987
Two new diterpenoids, designated neocryptotanshinone and isotanshinone IIB, have been isolated from "Tan-Shen," the root of Salvia miltiorrhiza, together with a known compound, danshexinkun A. Their structures are established by spectral and physical data.
A R, Lee, W L, Wu, W L, Chang, H C, Lin, M L, King   +4 more
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A simply triggered peptide-based hydrogel as an injectable nanocarrier of tanshinone IIA and tanshinones

Chemical Communications, 2017
An easily self-assembled and gelated octa-peptide FHFDFHFD was chosen as a novel drug delivery system (DDS) for both tanshinone IIA and total tanshinone extract.
Yajun, Yin, Can, Wu, Junling, Wang, Fengjuan, Song, Wanqing, Yue, Wenying, Zhong   +5 more
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Chemical Stability and Bioactivity of tanshinone I, tanshinone IIA, cryptotanshinone and dihydrotanshinone in in vitro test systems

Toxicology Letters, 2023
Danshen Si Wu is a Traditional Chinese Medicine used for menopausal complains. Beside tanshinone IIA (Tan IIA), Danshen also contains tanshinone I (Tan I), cryptotanshinone (CT) and dihydrotanshinone (DT). The aim of this study was to compare the biological activity of these tanshinones and to determine their cytotoxicity and genotoxicity. Purities and
Annika, Roth, Piwen, Zhao, Sebastian T, Soukup, Claudia, Guigas, Joachim, Stärke, Sabine E, Kulling, Patrick, Diel   +6 more
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Mass spectral studies on tanshinones

Organic Mass Spectrometry, 1970
AbstractThe mass spectra of three groups of tanshinones have been examined and a number of characteristic features noted which might be helpful in the micro‐identification of the natural products. The fragmentation patterns are similar to each other except for the relative intensity within the same group of tanshinones and are accounted for in terms of
T. Hayashi, Y. Inouye, M. Ohashi, H. Kakisawa, A. Tatematsu, T. Kinoshita   +5 more
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Synthesis and Antitumor Activity of Tanshinone Analogues

Chemistry of Natural Compounds, 2003
Abstract8,8‐Dimethyl‐5,6,7,8‐tetrahydrophenanthrene‐3,4‐dione (3) and 8,8‐dimethyl‐2‐(l‐hydroxy ethyl)‐5,6,7,8‐tetrahydrophenanthrene‐3,4‐dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active against leukemia P‐388 cell line as assayed by in vitro MTT
Aisa, HA, Lu, W, Cai, JC
openaire   +6 more sources