Results 41 to 50 of about 94,169 (259)

A pharmacist-led opioid de-escalation program after completion of chemoradiotherapy in locally advanced head and neck cancer

Frontiers in Oncology, 2023
BackgroundPersistent opioid use frequently leads to substantial negative impacts on quality of life, and as the outlook for numerous cancer types continues to improve, these complications become increasingly crucial.
Ai Horinouchi, Ai Horinouchi, Tomohiro Enokida, Shinya Suzuki, Hayato Kamata, Asumi Kaneko, Chihiro Matsuyama, Chihiro Matsuyama, Takao Fujisawa, Yuri Ueda, Yuri Ueda, Kazue Ito, Kazue Ito, Susumu Okano, Toshikatsu Kawasaki, Makoto Tahara   +15 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Drug tapering in animal research: current practices and challenges

Frontiers in Pharmacology
PurposeTo synthesize and summarize the scope and protocols of drug tapering in existing animal studies, providing a reference for standardized tapering interventions in future research.MethodsUtilizing a scoping review framework, a systematic search was ...
Yatong Zhang, Yatong Zhang, Mengrui Chen, Mengrui Chen, Tongtong Jiang, Tongtong Jiang, Qianfang Fu, Qianfang Fu, Rong Ma, Rong Ma, Lianghui Nie, Lianghui Nie, Yuqiong You, Yuqiong You, Shuqi Gao, Shuqi Gao, Ping Rong, Ping Rong   +17 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The story vs the storyteller: Factors associated with the effectiveness of brief video‐recorded patient stories for promoting opioid tapering

Health Expectations, 2021
Background Narrative communication is often more persuasive for promoting health behaviour change than communication using facts and figures; the extent to which narrative persuasiveness is due to patients’ identification with the storyteller vs ...
Stephen G. Henry, Bo Feng, Susan Verba, Richard L. Kravitz, Ana‐Maria Iosif   +4 more
doaj   +1 more source

Prescription of potentially addictive medications after a multilevel community intervention in general practice

Scandinavian Journal of Primary Health Care, 2023
Objective To evaluate the long-term effects of a multilevel community intervention to improve the quality of prescription practice of potentially addictive medications (PAMs).Design We conducted a retrospective study, using anonymized data from the ...
Muhunthan Navaratnam, Gunnhild Åberge Vie, Thea Brevik, Bjarne Austad, Cato Innerdal, Linn Okkenhaug Getz, Håvard Kjesbu Skjellegrind   +6 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

A small secret of big rheumatology

Научно-практическая ревматология
Current recommendations for RA treatment determine the need to reduce the dose and duration of glucocorticoid(GC) use. This is due to the wide spectrum and high frequency (up to 100%) of serious adverse events (AE) during GC treatment.
Andrey E. Karateev, Elena Yu. Polishchuk, Alena S. Potapova, Vera N. Amirjanova   +3 more
doaj   +1 more source

Low cost heat-and-pull rig for manufacturing adiabatic optical fiber tapers

Revista Facultad de Ingeniería Universidad de Antioquia, 2014
In this paper we report the fabrication of adiabatic tapered optical fbers using a low cost heat-and-pull rig. Our setup is based on the flame-brushing technique moving in zigzag, where an inexpensive and simple portable gas micro-torch is used as ...
Yamile Cardona Maya, Nelson Gómez Cardona, Pedro Ignacio Torres Trujillo   +2 more
doaj   +1 more source

“You can't shoot another bullet until you've reloaded the gun”: Coaches' perceptions, practices and experiences of deloading in strength and physique sports

Frontiers in Sports and Active Living, 2022
Deloading refers to a purposeful reduction in training demand with the intention of enhancing preparedness for successive training cycles. Whilst deloading is a common training practice in strength and physique sports, little is known about how the ...
Lee Bell, David Nolan, David Nolan, Velu Immonen, Eric Helms, Jake Dallamore, Milo Wolf, Patroklos Androulakis Korakakis   +7 more
doaj   +1 more source